公开(公告)号：US20170018784A1

公开(公告)日：2017-01-19

申请号：US15301111

申请日：2015-04-15

申请人： North Carolina Agricultural and Technical State University

发明人： Yeoheung Yun ,  Youngmi Koo

IPC分类号： H01M6/32 ,  H01M4/06 ,  H01M4/38 ,  H01M6/40

CPC分类号： H01M6/32 ,  H01M4/0414 ,  H01M4/06 ,  H01M4/38 ,  H01M6/12 ,  H01M6/22 ,  H01M6/40 ,  H01M6/46 ,  H01M2220/30 ,  H01M2300/0002

摘要： The present application relates generally to paper-based magnesium batteries, and the manufacture and use thereof, such as in wearable or point of care devices.

摘要翻译： 本申请一般涉及纸基镁电池，以及其制造和使用，例如在可穿戴或护理装置中。

公开(公告)号：US10308942B2

公开(公告)日：2019-06-04

申请号：US15683180

申请日：2017-08-22

申请人： University of Cincinnati ,  North Carolina Agricultural and Technical State University

发明人： Laura Conforti ,  Yeoheung Yun

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61K31/713 ,  A61K9/00 ,  A61K9/127 ,  A61K47/69 ,  C07K16/28

摘要： Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of T cells by selectively targeting memory T cells with the nanoparticles, which deliver their siRNA cargo into the cytosol of the TM cell thus reducing ion channel expression and decreasing Ca2+ influx.

公开(公告)号：US10128512B2

公开(公告)日：2018-11-13

申请号：US15301111

申请日：2015-04-15

申请人： North Carolina Agricultural and Technical State University

发明人： Yeoheung Yun ,  Youngmi Koo

IPC分类号： H01M6/32 ,  H01M6/40 ,  H01M4/06 ,  H01M4/38 ,  H01M6/12 ,  H01M6/22 ,  H01M4/04 ,  H01M6/46

摘要： The present application relates generally to paper-based magnesium batteries, and the manufacture and use thereof, such as in wearable or point of care devices.

公开(公告)号：US20170355998A1

公开(公告)日：2017-12-14

申请号：US15683180

申请日：2017-08-22

申请人： University of Cincinnati ,  North Carolina Agricultural and Technical State University

发明人： Laura Conforti ,  Yeoheung Yun

IPC分类号： C12N15/113 ,  A61K9/00 ,  A61K31/713 ,  A61K9/127 ,  A61K47/69 ,  C07K16/28

CPC分类号： C12N15/1138 ,  A61K9/0019 ,  A61K9/1272 ,  A61K31/713 ,  A61K47/6913 ,  C07K16/289 ,  C12N2310/14 ,  C12N2320/32

摘要： Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of T cells by selectively targeting memory T cells with the nanoparticles, which deliver their siRNA cargo into the cytosol of the TM cell thus reducing ion channel expression and decreasing Ca2+ influx.

公开(公告)号：US20160160220A1

公开(公告)日：2016-06-09

申请号：US14863525

申请日：2015-09-24

申请人： University of Cincinnati ,  North Carolina Agricultural and Technical State University

发明人： Laura Conforti ,  Yeoheung Yun

IPC分类号： C12N15/113 ,  A61K9/00 ,  A61K31/713 ,  A61K47/48 ,  C07K16/28

CPC分类号： C12N15/1138 ,  A61K9/0019 ,  A61K9/1272 ,  A61K31/713 ,  A61K47/6913 ,  C07K16/289 ,  C12N2310/14 ,  C12N2320/32

摘要： Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of T cells by selectively targeting memory T cells with the nanoparticles, which deliver their siRNA cargo into the cytosol of the TM cell thus reducing ion channel expression and decreasing Ca2+ influx.

摘要翻译： 包封离子通道敲除siRNA的抗体功能化纳米囊的合成和药物组合物，以及通过用纳米颗粒选择性靶向记忆T细胞来治疗与T细胞增加的表达和/或多动症相关的自身免疫性疾病的方法，其将其siRNA载体递送到细胞质 的TM细胞，从而减少离子通道表达并减少Ca2 +流入。

公开(公告)号：US09777279B2

公开(公告)日：2017-10-03

申请号：US14863525

申请日：2015-09-24

申请人： University of Cincinnati ,  North Carolina Agricultural and Technical State University

发明人： Laura Conforti ,  Yeoheung Yun

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61K31/713 ,  A61K9/00 ,  A61K47/48 ,  A61K9/127 ,  C07K16/28

CPC分类号： C12N15/1138 ,  A61K9/0019 ,  A61K9/1272 ,  A61K31/713 ,  A61K47/6913 ,  C07K16/289 ,  C12N2310/14 ,  C12N2320/32

摘要： Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of T cells by selectively targeting memory T cells with the nanoparticles, which deliver their siRNA cargo into the cytosol of the TM cell thus reducing ion channel expression and decreasing Ca2+ influx.

公开(公告)号：US20160351918A1

公开(公告)日：2016-12-01

申请号：US15116708

申请日：2015-02-05

申请人： NORTH CAROLINA AGRICULTURAL AND TECHNICAL STATE UNIVERSITY

发明人： Yeoheung Yun ,  Youngmi Koo ,  Jagannathan Sankar

IPC分类号： H01M4/90 ,  H01M4/88 ,  C01B31/18 ,  C01B31/02 ,  C07C1/12 ,  C10G2/00 ,  C25B1/00 ,  C25B3/04 ,  H01M8/0202 ,  C25D5/54 ,  C23C14/18 ,  C23C16/44 ,  B32B37/14 ,  B32B38/10 ,  H01M4/92

CPC分类号： H01M4/9083 ,  B01J27/20 ,  B01J35/004 ,  B32B37/14 ,  B32B38/10 ,  B82Y30/00 ,  C01B32/168 ,  C01B32/174 ,  C01B32/40 ,  C07C1/12 ,  C07C2521/06 ,  C07C2521/18 ,  C07C2523/14 ,  C07C2523/42 ,  C07C2523/50 ,  C07C2523/52 ,  C07C2523/72 ,  C10G2/50 ,  C23C14/18 ,  C23C16/44 ,  C25B1/003 ,  C25B3/04 ,  C25D5/54 ,  H01M4/8817 ,  H01M4/8853 ,  H01M4/9016 ,  H01M4/9041 ,  H01M4/921 ,  H01M4/923 ,  H01M4/926 ,  H01M8/0202

摘要： The present subject matter relates generally to the derivatization of highly-aligned carbon nanotube sheet substrates with one or more transition metal centers and to uses of the resulting metal-derivatized CNT sheet substrates.

摘要翻译： 本主题一般涉及具有一个或多个过渡金属中心的高度排列的碳纳米管片基材的衍生化以及所得金属衍生的CNT片基材的用途。