公开(公告)号：US10183025B2

公开(公告)日：2019-01-22

申请号：US15673155

申请日：2017-08-09

Applicant: Novartis AG

Inventor： David Beattie ,  Urs Baettig ,  Darren Mark Le Grand ,  Andrew Stuart Lister ,  Jeffrey McKenna ,  David William Pearce ,  David Andrew Sandham ,  Oliver Ross Steward ,  Christopher Thomson

IPC: A61K31/445 ,  A61K31/551 ,  C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/5377 ,  A61K31/5513 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D403/14 ,  C07D407/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/14 ,  C07D257/04 ,  A61K45/06 ,  A61K31/45 ,  A61K31/496 ,  A61K31/504 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D405/12 ,  C07D471/08

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

公开(公告)号：US09763957B2

公开(公告)日：2017-09-19

申请号：US14906161

申请日：2014-07-16

Applicant: Novartis AG

Inventor： David Beattie ,  Urs Baettig ,  Darren Mark Legrand ,  Andrew Stuart Lister ,  Jeffrey McKenna ,  David William Pearce ,  David Andrew Sandham ,  Oliver Ross Steward ,  Christopher Thomson

IPC: A61K31/445 ,  A61K31/551 ,  C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/5377 ,  A61K31/5513 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D403/14 ,  C07D407/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/14 ,  C07D257/04 ,  A61K45/06 ,  A61K31/45 ,  A61K31/496 ,  A61K31/504 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  C07D405/12 ,  C07D471/08

CPC classification number: A61K31/551 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/445 ,  A61K31/45 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/504 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  C07D257/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/08 ,  A61K2300/00

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.