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公开(公告)号：US20150307475A1
公开(公告)日：2015-10-29
申请号：US14653649
申请日：2013-12-17
Applicant: NOVARTIS AG
Inventor： Vikkie Furminger , Owen Rhys Hughes , Darren Mark Legrand , Emily Stanley , Christopher Thomson
IPC: C07D401/12 , A61K31/454
CPC classification number: C07D401/12 , A61K31/4192 , A61K31/445 , A61K31/454 , A61K31/46 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D211/26 , C07D211/32 , C07D211/34 , C07D211/58 , C07D211/60 , C07D249/04 , C07D263/38 , C07D265/30 , C07D401/06 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04
Abstract: The present invention relates to novel compounds of formula (I) (I) that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.
Abstract translation: 本发明涉及新型的式（I）（I）化合物，其为自分泌抑素，其制备方法，药物组合物和含有它们的药物及其用于治疗ATX依赖性或ATX介导的疾病或病症 。
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公开(公告)号：US10183025B2
公开(公告)日：2019-01-22
申请号：US15673155
申请日：2017-08-09
Applicant: Novartis AG
Inventor： David Beattie , Urs Baettig , Darren Mark Le Grand , Andrew Stuart Lister , Jeffrey McKenna , David William Pearce , David Andrew Sandham , Oliver Ross Steward , Christopher Thomson
IPC: A61K31/445 , A61K31/551 , C07D403/12 , C07D401/14 , C07D413/14 , A61K31/41 , A61K31/4245 , A61K31/427 , A61K31/5377 , A61K31/5513 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/14 , C07D407/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/14 , C07D257/04 , A61K45/06 , A61K31/45 , A61K31/496 , A61K31/504 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D405/12 , C07D471/08
Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.
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公开(公告)号：US09763957B2
公开(公告)日：2017-09-19
申请号：US14906161
申请日：2014-07-16
Applicant: Novartis AG
Inventor： David Beattie , Urs Baettig , Darren Mark Legrand , Andrew Stuart Lister , Jeffrey McKenna , David William Pearce , David Andrew Sandham , Oliver Ross Steward , Christopher Thomson
IPC: A61K31/445 , A61K31/551 , C07D403/12 , C07D401/14 , C07D413/14 , A61K31/41 , A61K31/4245 , A61K31/427 , A61K31/5377 , A61K31/5513 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/14 , C07D407/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D417/14 , C07D257/04 , A61K45/06 , A61K31/45 , A61K31/496 , A61K31/504 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D405/12 , C07D471/08
CPC classification number: A61K31/551 , A61K31/41 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/504 , A61K31/506 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D257/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/08 , A61K2300/00
Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.
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公开(公告)号：US09751876B2
公开(公告)日：2017-09-05
申请号：US14511044
申请日：2014-10-09
Applicant: Novartis AG
Inventor： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
IPC: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , A61K31/4745
CPC classification number: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
Abstract: Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.
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