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公开(公告)号：US20220025032A1
公开(公告)日：2022-01-27
申请号：US17375860
申请日：2021-07-14
申请人： NOVARTIS AG
发明人： Chad Eric BIGELOW , Ana Maria CARRION , James Edgar CHASTAIN , Kirk Lee CLARK , Bijan Alexandre ETEMAD-GILBERTSON , Joy Gispati GHOSH , Shawn Michael HANKS , Nicole HAUBST , Ganesh Rajan IYER , Nina MOKER , Andrew Anh NGUYEN , Stephen Hendrick POOR , Yubin QIU , Nalini Velamur RANGASWAMY , Michael STEFANIDAKIS , Engin TOKSOZ , Michael Zbigniew TWAROG
摘要： The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
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公开(公告)号：US20220348646A1
公开(公告)日：2022-11-03
申请号：US17809943
申请日：2022-06-30
申请人： NOVARTIS AG
发明人： Chad Eric BIGELOW , Ana Maria CARRION , James Edgar CHASTAIN , Kirk Lee CLARK , Bijan Alexandre ETEMAD-GILBERTSON , Joy Gispati GHOSH , Shawn Michael HANKS , Nicole HAUBST , Ganesh Rajan IYER , Nina MOKER , Andrew Anh NGUYEN , Stephen Hendrick POOR , Yubin QIU , Nalini Velamur RANGASWAMY , Michael STEFANIDAKIS , Engin TOKSOZ , Michael Zbigniew TWAROG
摘要： The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
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公开(公告)号：US20230323398A1
公开(公告)日：2023-10-12
申请号：US18160241
申请日：2023-01-26
申请人： Novartis AG
发明人： Chad Eric BIGELOW , Vivian CHOI , Thaddeus Peter DRYJA , Akshata Ninad GUJAR , Shawn Michael HANKS , Terri MCGEE , Seshidhar Reddy POLICE , Joanna VROUVLIANIS
CPC分类号： C12N15/86 , A61K38/1709 , A61K48/005 , A61K48/0058 , C07K14/47 , C12N7/00 , C12N15/79
摘要： The present invention relates to viral vectors that are capable of delivering a heterologous gene to the retina and in particular delivering RLBP1 to RPE and Müller cells of the retina. The invention also relates nucleic acids useful for producing viral vectors, compositions comprising the viral vectors and uses of the compositions and viral vectors. The invention also relates to methods of delivering and/or expressing a heterologous gene to the retina, improving the rate of dark adaption in a subject and treating RLBP1-associated retinal dystrophy.
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公开(公告)号：US20210047656A1
公开(公告)日：2021-02-18
申请号：US16725081
申请日：2019-12-23
申请人： Novartis AG
摘要： The present invention relates to viral vectors that are capable of delivering a heterologous gene to the retina and in particular delivering RLBP1 to RPE and Müller cells of the retina. The invention also relates nucleic acids useful for producing viral vectors, compositions comprising the viral vectors and uses of the compositions and viral vectors. The invention also relates to methods of delivering and/or expressing a heterologous gene to the retina, improving the rate of dark adaption in a subject and treating RLBP1-associated retinal dystrophy.
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公开(公告)号：US20220356236A1
公开(公告)日：2022-11-10
申请号：US17809941
申请日：2022-06-30
申请人： NOVARTIS AG
发明人： Chad Eric BIGELOW , Ana Maria CARRION , James Edgar CHASTAIN , Kirk Lee CLARK , Bijan Alexandre ETEMAD-GILBERTSON , Joy Gispati GHOSH , Shawn Michael HANKS , Nicole HAUBST , Ganesh Rajan IYER , Nina MOKER , Andrew Anh NGUYEN , Stephen Hendrick POOR , Yubin QIU , Nalini Velamur RANGASWAMY , Michael STEFANIDAKIS , Engin TOKSOZ , Michael Zbigniew TWAROG
摘要： The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
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公开(公告)号：US20180080046A1
公开(公告)日：2018-03-22
申请号：US15713021
申请日：2017-09-22
申请人： Novartis AG
摘要： The present invention relates to viral vectors that are capable of delivering a heterologous gene to the retina and in particular delivering RLBP1 to RPE and Müller cells of the retina. The invention also relates nucleic acids useful for producing viral vectors, compositions comprising the viral vectors and uses of the compositions and viral vectors. The invention also relates to methods of delivering and/or expressing a heterologous gene to the retina, improving the rate of dark adaption in a subject and treating RLBP1-associated retinal dystrophy.
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