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    SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING
    2.
    发明申请
    SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 有权
    硅胶水晶镜片，带有交联胶粘剂

    公开(公告)号：US20130118127A1

    公开(公告)日：2013-05-16

    申请号：US13675805

    申请日：2012-11-13

    申请人： Novartis AG

    发明人： Chandana Kolluru ,  Bradley Quinter

    IPC分类号： B65B5/04 ,  G02C7/04

    CPC分类号： G02B1/043 ,  B29C35/0805 ,  B29C2035/0827 ,  B29D11/00038 ,  B29D11/00134 ,  B29D11/00865 ,  B29K2083/00 ,  B29K2105/0061 ,  B29K2833/12 ,  B29K2909/08 ,  B29K2995/0027 ,  B29K2995/0092 ,  B65B5/04 ,  G02C7/049 ,  G02C2202/16 ,  C08L101/14 ,  C08L101/02

    摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves autoclaving, in a sealed lens package, a silicone hydrogel contact lens having a base coating of polyacrylic acid thereon in an aqueous solution in the presence of a water-soluble, crosslinkable hydrophilic polymeric material having epoxide groups, for a period of time sufficient to covalently attach the crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one epoxide group and one of the carboxyl groups on and/or near the surface of the silicone hydrogel contact lens.

    摘要翻译： 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法包括在密封的镜片包装中，在具有环氧基团的水溶性，可交联的亲水性聚合物材料存在下，在水溶液中具有聚丙烯酸基底涂层的硅酮水凝胶隐形眼镜进行高压灭菌，用于 足以将可交联亲水性聚合物材料共价连接到硅酮水凝胶隐形眼镜的表面上，通过在硅氧烷水凝胶隐形眼镜的表面上和/或附近的一个环氧基和一个羧基之间形成的共价键。

    Silicone hydrogel lens with a crosslinked hydrophilic coating
    4.
    发明授权
    Silicone hydrogel lens with a crosslinked hydrophilic coating 有权
    硅胶水凝胶透镜与交联的亲水涂层

    公开(公告)号：US09505184B2

    公开(公告)日：2016-11-29

    申请号：US13675805

    申请日：2012-11-13

    申请人： Novartis AG

    发明人： Chandana Kolluru ,  Bradley Quinter

    IPC分类号： B29D11/00 ,  B65B5/04 ,  G02C7/04 ,  G02B1/04

    CPC分类号： G02B1/043 ,  B29C35/0805 ,  B29C2035/0827 ,  B29D11/00038 ,  B29D11/00134 ,  B29D11/00865 ,  B29K2083/00 ,  B29K2105/0061 ,  B29K2833/12 ,  B29K2909/08 ,  B29K2995/0027 ,  B29K2995/0092 ,  B65B5/04 ,  G02C7/049 ,  G02C2202/16 ,  C08L101/14 ,  C08L101/02

    摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves autoclaving, in a sealed lens package, a silicone hydrogel contact lens having a base coating of polyacrylic acid thereon in an aqueous solution in the presence of a water-soluble, crosslinkable hydrophilic polymeric material having epoxide groups, for a period of time sufficient to covalently attach the crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one epoxide group and one of the carboxyl groups on and/or near the surface of the silicone hydrogel contact lens.

    摘要翻译： 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法包括在密封的镜片包装中，在具有环氧基团的水溶性，可交联的亲水性聚合物材料存在下，在水溶液中具有聚丙烯酸基底涂层的硅酮水凝胶隐形眼镜进行高压灭菌，用于 足以将可交联亲水性聚合物材料共价连接到硅酮水凝胶隐形眼镜的表面上，通过在硅氧烷水凝胶隐形眼镜的表面上和/或附近的一个环氧基和一个羧基之间形成的共价键。

    SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING
    7.
    发明申请
    SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 审中-公开

    公开(公告)号：US20190154880A1

    公开(公告)日：2019-05-23

    申请号：US16254966

    申请日：2019-01-23

    申请人： Novartis AG

    发明人： Chandana Kolluru ,  Bradley Quinter

    IPC分类号： G02B1/04 ,  B65B5/04 ,  G02C7/04 ,  B29D11/00

    摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves autoclaving, in a sealed lens package, a silicone hydrogel contact lens having a base coating of polyacrylic acid thereon in an aqueous solution in the presence of a water-soluble, crosslinkable hydrophilic polymeric material having epoxide groups, for a period of time sufficient to covalently attach the crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one epoxide group and one of the carboxyl groups on and/or near the surface of the silicone hydrogel contact lens.

    Silicone hydrogel lens with a crosslinked hydrophilic coating
    8.
    发明授权
    Silicone hydrogel lens with a crosslinked hydrophilic coating 有权

    公开(公告)号：US10222509B2

    公开(公告)日：2019-03-05

    申请号：US15333214

    申请日：2016-10-25

    申请人： Novartis AG

    发明人： Chandana Kolluru ,  Bradley Quinter

    IPC分类号： G02B1/04 ,  B29D11/00 ,  B65B5/04 ,  G02C7/04 ,  B29C35/08 ,  B29K83/00 ,  B29K105/00

    摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves autoclaving, in a sealed lens package, a silicone hydrogel contact lens having a base coating of polyacrylic acid thereon in an aqueous solution in the presence of a water-soluble, crosslinkable hydrophilic polymeric material having epoxide groups, for a period of time sufficient to covalently attach the crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one epoxide group and one of the carboxyl groups on and/or near the surface of the silicone hydrogel contact lens.

    SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING
    10.
    发明申请
    SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING 有权
    硅胶水晶镜片，带有交联胶粘剂

    公开(公告)号：US20150099822A1

    公开(公告)日：2015-04-09

    申请号：US14571350

    申请日：2014-12-16

    申请人： Novartis AG

    发明人： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

    IPC分类号： G02B1/10 ,  G02B1/04

    CPC分类号： C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

    摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

    摘要翻译： 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。