公开(公告)号：US20180022690A1

公开(公告)日：2018-01-25

申请号：US15550224

申请日：2016-02-11

Applicant: Novartis AG

Inventor： Benjamin MARTIN ,  Francesca MANDRELLI ,  Francesco VENTURONI

IPC: C07C201/10 ,  C07C205/44 ,  C07C205/04 ,  B01J31/02 ,  C07C335/16 ,  C07D207/06 ,  C07F9/535 ,  C07C205/51 ,  C07C201/12

CPC classification number: C07C201/10 ,  B01J31/0237 ,  B01J31/0241 ,  B01J31/0244 ,  B01J31/0265 ,  C07B2200/07 ,  C07C201/12 ,  C07C205/04 ,  C07C205/44 ,  C07C205/51 ,  C07C227/04 ,  C07C335/16 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/06 ,  C07F7/1804 ,  C07F9/5355 ,  C07C205/53 ,  C07C229/34

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.