公开(公告)号：US20140030823A1

公开(公告)日：2014-01-30

申请号：US14043267

申请日：2013-10-01

Applicant: OLYMPUS CORPORATION

Inventor： Hiromi SANUKI ,  Rie KATAOKA ,  Nao MORIYA

IPC: G01N21/78

CPC classification number: G01N21/78 ,  A61B5/4216 ,  A61B10/0045 ,  C12Q1/68 ,  G01N33/487 ,  G01N33/57438 ,  G01N33/6893 ,  G01N2800/067

Abstract: A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration of S100P in at least one of a pancreatic juice and a body fluid containing pancreatic juice collected from a test subject by immunochromatography. Additionally provided is a pancreas testing kit including an immunochromatography device that holds an anti-S100P antibody and a collection vessel that retains a protease inhibitor that inhibits an activity of a protease contained in the pancreatic juice.

Abstract translation: 即使使用简单的设备和简单的程序，胰腺疾病也会以高灵敏度进行测试。 本发明提供一种检测胰腺疾病的方法，包括通过免疫色谱法检测从受试者收集的含有胰液的胰液和体液中的至少一种中S100P的浓度。 另外提供了胰腺检测试剂盒，其包括含有抗S100P抗体的免疫层析装置和保留抑制胰液中所含蛋白酶活性的蛋白酶抑制剂的收集容器。

公开(公告)号：US20170290572A1

公开(公告)日：2017-10-12

申请号：US15094789

申请日：2016-04-08

Applicant: OLYMPUS CORPORATION

Inventor： Mari NAKATA ,  Hiromi SANUKI ,  Junichi MURAMATSU ,  Keita SHOJI

IPC: A61B10/02 ,  A61B8/12 ,  A61M5/32 ,  A61B10/00

CPC classification number: A61B10/0233 ,  A61B1/00112 ,  A61B1/0057 ,  A61B1/015 ,  A61B1/018 ,  A61B8/085 ,  A61B8/12 ,  A61B10/0045 ,  A61B2010/0061 ,  A61B2010/0216

Abstract: A method for collecting tissue includes a body fluid removal step in which a body fluid inside a pancreatic cyst is moved to an outside of the pancreatic cyst, an injecting step in which a liquid different from the body fluid is injected into the pancreatic cyst, a collecting step in which the liquid is collected from the pancreatic cyst, and a separating step in which tissue of an inner wall of the pancreatic cyst, which is contained in the liquid collected from the pancreatic cyst, is separated from the liquid.

公开(公告)号：US20140186863A1

公开(公告)日：2014-07-03

申请号：US14199136

申请日：2014-03-06

Applicant: OLYMPUS CORPORATION

Inventor： Hiromi SANUKI ,  Nao MORIYA ,  Rie KATAOKA

IPC: G01N33/574

CPC classification number: G01N33/57438

Abstract: The present invention relates to a method for detecting a marker for pancreatic disease for obtaining highly reliable results while reducing the risk of complications. It also relates to a method for a detecting a marker for pancreatic disease comprising: measuring the concentration of a marker for pancreatic disease in duodenal juice that is collected from a subject and contains spontaneously discharged pancreatic juice, by a measurement method including detecting antigen or antibody immobilized on a solid phase using an antigen-antibody reaction, and the aforementioned method for detecting a marker for pancreatic disease further including judging the subject to have the possibility of being afflicted with a pancreatic disease in the case the concentration of the marker for pancreatic disease is equal to or greater than a prescribed threshold value.

Abstract translation: 本发明涉及一种用于检测胰腺疾病标志物的方法，以获得高度可靠的结果，同时降低并发症的风险。 本发明还涉及一种胰腺疾病标志物的检测方法，其特征在于，包括：检测受试者收集的十二指肠液中胰腺疾病的标记物浓度，并含有自发排出的胰液，包括检测抗原或抗体 使用抗原 - 抗体反应固定在固相上，以及上述用于检测胰腺疾病标志物的方法，其进一步包括判断受试者在胰腺疾病标志物浓度的情况下可能患有胰腺疾病 等于或大于规定的阈值。

公开(公告)号：US20170122957A1

公开(公告)日：2017-05-04

申请号：US15404861

申请日：2017-01-12

Applicant: OLYMPUS CORPORATION

Inventor： Hiromi SANUKI ,  Mari NAKATA ,  Tetsuhide TAKEYAMA

IPC: G01N33/68

CPC classification number: G01N33/68 ,  G01N33/48

Abstract: A method of determining pancreatic disease of the present invention is a method of determining whether an IPMN patient has pancreatic disease, the method including: a first step of measuring a concentration of S100P in duodenal juice of the IPMN patient; and a second step of determining the IPMN patient is a malignant IPMN patient or a pancreatic cancer patient when the concentration of the S100P is equal to or greater than a predetermined cutoff value, and the IPMN patient is a benign IPMN patient when the concentration of the S100P is smaller than the predetermined cutoff value.

公开(公告)号：US20230149043A1

公开(公告)日：2023-05-18

申请号：US17989186

申请日：2022-11-17

Applicant: OLYMPUS CORPORATION

Inventor： Kazuhiro GONO ,  Hiromi SANUKI

IPC: A61B17/34 ,  A61B1/273 ,  A61B1/00 ,  A61B1/015

CPC classification number: A61B17/3478 ,  A61B1/2736 ,  A61B1/000096 ,  A61B1/015 ,  A61B2017/00893

Abstract: A cannulation method includes inserting an endoscope into a duodenum, bringing a distal end section of the endoscope to a position where a duodenal papilla is within a field of view of the endoscope, promoting secretion of pancreatic juice or bile by administering a drainage stimulant, determining an amount of relaxation of the duodenal papilla, and performing cannulation into a biliary duct through the duodenal papilla where the amount of relaxation is greater than a predetermined amount.

公开(公告)号：US20180238906A1

公开(公告)日：2018-08-23

申请号：US15961012

申请日：2018-04-24

Applicant: OLYMPUS CORPORATION

Inventor： Mari NAKATA ,  Hiromi SANUKI ,  Tetsuhide TAKEYAMA ,  Shoji TOKUNAGA ,  Masao TANAKA

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/48 ,  G01N33/68 ,  G01N2333/4727 ,  G01N2800/50

Abstract: The purpose of the present invention is to provide a method for evaluating the possibility of suffering from pancreatic disease on the basis of the concentration of a pancreatic disease marker in a duodenal juice sample. The method for evaluating the possibility of suffering from pancreatic disease of the present invention has a step for (a) measuring the concentration of the pancreatic disease marker in a duodenal juice sample taken from a subject and a step for (b) evaluating the possibility of the subject suffering from pancreatic disease on the basis of the concentration of the pancreatic disease marker measured in step (a) and the age of the subject.

公开(公告)号：US20160116476A1

公开(公告)日：2016-04-28

申请号：US14981144

申请日：2015-12-28

Applicant: OLYMPUS CORPORATION

Inventor： Rie TAKEICHI ,  Nao SHIMADA ,  Hiromi SANUKI ,  Mari NAKATA ,  Masanobu KIYOHARA ,  Tetsuhide TAKEYAMA ,  Tomonori NAGAOKA

IPC: G01N33/574 ,  G01N21/29 ,  G01N33/68 ,  G01N21/31

CPC classification number: G01N33/57438 ,  A61B5/1032 ,  A61B5/4283 ,  A61B2010/0061 ,  G01N21/29 ,  G01N21/293 ,  G01N21/31 ,  G01N33/48 ,  G01N33/6872 ,  G01N2333/70503 ,  G01N2800/067

Abstract: Provided are a method for exclusively selecting a duodenal fluid sample having a high possibility of containing pancreatic fluid and favorable sample suitability for subjecting to detection of a pancreatic disease marker by evaluating the quality of the sample prior to detecting the pancreatic disease marker, and a method for detecting a pancreatic disease marker using a duodenal fluid sample selected according to that method. Namely, a method is provided for selecting a duodenal fluid sample for detecting a pancreatic disease marker, comprising: (a1) a step of comparing the color depth of a duodenal fluid sample with a prescribed standard color, and (b1) a step of determining that a duodenal fluid sample is subjected to a test for a pancreatic disease marker if the color depth thereof is equal to or higher than the standard color, but that the duodenal fluid sample is not subjected to a test for a pancreatic disease marker if the color depth thereof is lower than the standard color.

Abstract translation: 提供了一种专门选择具有高含有胰液的可能性的十二指肠液样品的方法，并且在检测胰腺疾病标记物之前通过评估样品的质量来评估对胰腺疾病标记物的检测的良好样品适合性的方法，以及方法 用于使用根据该方法选择的十二指肠液体样品检测胰腺疾病标记物。 即，提供一种选择用于检测胰腺疾病标记物的十二指肠液样品的方法，包括：（a1）将十二指肠液样品的颜色深度与规定的标准颜色进行比较的步骤，（b1）确定 如果十进制液体样品的颜色深度等于或高于标准颜色，则对十二指肠液样品进行胰腺疾病标记物的测试，但如果十进制液体样品的颜色 其深度低于标准颜色。

公开(公告)号：US20150104846A1

公开(公告)日：2015-04-16

申请号：US14576437

申请日：2014-12-19

Applicant: OLYMPUS CORPORATION

Inventor： Rie KATAOKA ,  Nao MORIYA ,  Hiromi SANUKI

IPC: C12N9/99 ,  C09K15/28

CPC classification number: C12N9/99 ,  C09K15/28 ,  G01N33/57438

Abstract: The present invention provides a method for preserving biological components in pancreatic juice, and a kit suited for this method. The method involves adding, to a pancreatic juice-containing biological sample, at least one sulfonyl fluoride-containing protease inhibitor and at least one trypsin-like serine protease inhibitor belonging to a group of amino acid chloromethyl ketones.

Abstract translation: 本发明提供了一种保存胰汁中生物成分的方法，以及适用于该方法的试剂盒。 该方法包括向含有胰液的生物样品中加入至少一种含磺酰氟的蛋白酶抑制剂和至少一种属于一组氨基酸氯甲基酮的胰蛋白酶样丝氨酸蛋白酶抑制剂。