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1.发明授权Quinazoline derivatives, their preparation, their use, and medicaments comprising them 失效喹唑啉衍生物，它们的制备方法，用途和包含它们的药物公开(公告)号：US07741333B2
公开(公告)日：2010-06-22
申请号：US11766232
申请日：2007-06-21
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic E. A. Brittain
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic E. A. Brittain
IPC分类号： A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D513/04 , C07D239/70 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a quinazoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹唑啉衍生物：其中R1，R2，X，Y和Z在说明书和权利要求中表示，通式（A）的化合物用于 各种病症的治疗，以及通式（A）的化合物的制备。
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2.发明申请QUINAZOLINE DERIVATIVES, THEIR PREPARATION, THEIR USE, AND MEDICAMENTS COMPRISING THEM 失效喹诺酮衍生物，其制备，其使用和药物包括它们公开(公告)号：US20080019922A1
公开(公告)日：2008-01-24
申请号：US11766232
申请日：2007-06-21
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic Brittain
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic Brittain
IPC分类号： A61K49/04 , A61K31/495 , A61P9/00 , C07D239/72
CPC分类号： C07D513/04 , C07D239/70 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a quinazoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹唑啉衍生物：其中R 1，R 2，X，Y和Z在说明书中表示， 权利要求书中，使用通式（A）的化合物治疗各种病症，以及制备通式（A）的化合物。
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3.发明授权Cyanoquinoline derivatives, their preparation, their use, and medicaments comprising them 失效氰基喹啉衍生物，它们的制备方法，用途以及包含它们的药物公开(公告)号：US07598263B2
公开(公告)日：2009-10-06
申请号：US11765813
申请日：2007-06-20
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf
IPC分类号： A61K31/435 , C07D215/00
CPC分类号： C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉衍生物：其中R1，R2，X，Y和Z在说明书和权利要求中表示，通式（A）的化合物用于 各种病症的治疗，以及通式（A）的化合物的制备。
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4.发明申请CYANOQUINOLINE DERIVATIVES, THEIR PREPARATION, THEIR USE, AND MEDICAMENTS COMPRISING THEM 失效氰基喹啉衍生物，其制备，其使用和药物包括它们公开(公告)号：US20080108627A1
公开(公告)日：2008-05-08
申请号：US11765813
申请日：2007-06-20
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf
IPC分类号： A61K31/497 , A61P35/00 , A61P25/28 , C07D521/00 , C07D401/14 , A61K31/4365
CPC分类号： C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉衍生物：其中R 1，R 2，X，Y和Z在说明书中表示， 权利要求书中，使用通式（A）的化合物治疗各种病症，以及制备通式（A）的化合物。
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5.发明申请Quinoline derivatives, their preparation, their use, and medicaments comprising them 审中-公开喹啉衍生物，其制备方法，用途以及包含它们的药物公开(公告)号：US20080056987A1
公开(公告)日：2008-03-06
申请号：US11765683
申请日：2007-06-20
申请人： Olaf Prien , Knut Eis , Duy Nguyen , Christoph Huwe , Wolfgang Schwede , Judith Guenther , Dieter Zopf
发明人： Olaf Prien , Knut Eis , Duy Nguyen , Christoph Huwe , Wolfgang Schwede , Judith Guenther , Dieter Zopf
IPC分类号： A61K51/00 , A61K31/47 , A61P25/00 , A61P9/00 , C07D295/00 , C12Q1/00 , C12N9/99 , C07D215/00 , A61P43/00 , A61K31/5377
CPC分类号： C07D513/04 , C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A) in which R1, R2, W, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉衍生物，其中R 1，R 2，W，X，Y和Z在说明书中表示， 权利要求书，通式（A）的化合物用于各种病症的治疗，以及制备通式（A）的化合物。
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6.发明授权Sulphoximine-substituted quinoline and quinazoline derivatives as kinase inhibitors 失效磺酰亚胺取代的喹啉和喹唑啉衍生物作为激酶抑制剂公开(公告)号：US08003787B2
公开(公告)日：2011-08-23
申请号：US12126437
申请日：2008-05-23
申请人： Knut Eis , Olaf Prien , Ulrich Lücking , Judith Günther , Dieter Zopf , Dirk Brohm , Verena Vöhringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
发明人： Knut Eis , Olaf Prien , Ulrich Lücking , Judith Günther , Dieter Zopf , Dirk Brohm , Verena Vöhringer , Elisabeth Woltering , Hartmut Beck , Mario Lobell , Volkhart Min-Jian Li , Susanne Greschat
IPC分类号： C07D239/86
CPC分类号： C07D239/86 , C07D215/44 , C07D409/04
摘要： The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹啉或喹唑啉衍生物：其中R3，R4，W，Y和Q在说明书和权利要求中表示，通式（A）的化合物的用途， 用于治疗各种疾病，以及制备通式（A）的化合物。
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![Oxo-substituted imidazo[1,2b]pyridazines, their preparation and use as pharmaceuticals](/abs-image/US/2009/04/09/US20090093475A1/abs.jpg.150x150.jpg)
7.发明申请Oxo-substituted imidazo[1,2b]pyridazines, their preparation and use as pharmaceuticals 失效氧代取代的咪唑并[1,2b]哒嗪，其制备和用作药物公开(公告)号：US20090093475A1
公开(公告)日：2009-04-09
申请号：US11765638
申请日：2007-06-20
申请人： Olaf PRIEN , Knut Eis , Benjamin Bader , Judith Guenther , Arne Von Bonin
发明人： Olaf PRIEN , Knut Eis , Benjamin Bader , Judith Guenther , Arne Von Bonin
IPC分类号： A61K31/5377 , C07D487/04 , A61P37/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P3/10 , A61K31/5025
CPC分类号： C07D487/04
摘要： The invention relates to novel inhibitors of kinases of the general formula (I): in which Q and R1 are defined in the claims, method for preparing such inhibitors, intermediates for preparing such inhibitors and uses of such inhibitors.
摘要翻译： 本发明涉及通式（I）的新型激酶抑制剂：其中Q和R 1在权利要求书中定义，制备这种抑制剂的方法，制备这种抑制剂的中间体和这种抑制剂的用途。
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8.发明申请Thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents 审中-公开没有碱性氮的噻唑烷酮，其生产和用作药剂公开(公告)号：US20070010566A1
公开(公告)日：2007-01-11
申请号：US11410285
申请日：2006-04-25
申请人： Olaf Prien , Volker Schulze , Knut Eis , Lars Wortmann , Dirk Kosemund , Gerhard Siemeister , Uwe Eberspaecher , Judith Guenther , Dominic Brittain
发明人： Olaf Prien , Volker Schulze , Knut Eis , Lars Wortmann , Dirk Kosemund , Gerhard Siemeister , Uwe Eberspaecher , Judith Guenther , Dominic Brittain
IPC分类号： A61K31/427 , C07D417/02
CPC分类号： C07D277/34 , C07D417/06
摘要： The invention relates to thiazolidones of general formula (I) as welt as to their production and to their use as inhibitors of the polo-like kinase (Plk) for treating various diseases, as welt as to intermediate products for the production of the compounds according to the invention.
摘要翻译： 本发明涉及通式（I）的噻唑烷酮，其生产方式及其用作治疗各种疾病的polo样激酶（Plk）的抑制剂的用途，如用于生产化合物的中间产物 涉及本发明。
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![Oxo-substituted imidazo[1,2B]pyridazines, their preparation and use as pharmaceuticals](/abs-image/US/2014/02/18/US08653076B2/abs.jpg.150x150.jpg)
9.发明授权Oxo-substituted imidazo[1,2B]pyridazines, their preparation and use as pharmaceuticals 失效氧代取代的咪唑并[1,2B]哒嗪，其制备和用作药物公开(公告)号：US08653076B2
公开(公告)日：2014-02-18
申请号：US11765638
申请日：2007-06-20
申请人： Olaf Prien , Knut Eis , Benjamin Bader , Judith Guenther , Arne Von Bonin
发明人： Olaf Prien , Knut Eis , Benjamin Bader , Judith Guenther , Arne Von Bonin
IPC分类号： C07D487/04 , A61K31/5025 , A61P29/00 , A61P3/10 , A61P11/06
CPC分类号： C07D487/04
摘要： The invention relates to novel inhibitors of kinases of the general formula (I): in which Q and R1 are defined in the claims, method for preparing such inhibitors, intermediates for preparing such inhibitors and uses of such inhibitors.
摘要翻译： 本发明涉及通式（I）的新型激酶抑制剂：其中Q和R 1在权利要求书中定义，制备这种抑制剂的方法，制备这种抑制剂的中间体和这种抑制剂的用途。
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10.发明申请New thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents 审中-公开不含碱性氮的新型噻唑烷酮，其生产和用作药剂公开(公告)号：US20070010565A1
公开(公告)日：2007-01-11
申请号：US11410284
申请日：2006-04-25
申请人： Olaf Prien , Volker Schulze , Knut Eis , Lars Wortmann , Dirk Kosemund , Gerhard Siemeister , Uwe Eberspaecher , Judith Guenther , Dominic Brittain
发明人： Olaf Prien , Volker Schulze , Knut Eis , Lars Wortmann , Dirk Kosemund , Gerhard Siemeister , Uwe Eberspaecher , Judith Guenther , Dominic Brittain
IPC分类号： A61K31/426
CPC分类号： C07D277/34
摘要： The invention relates to thiazolidones of general formula (I): to their production and to their use as inhibitors of the polo-like kinase (Plk) for treating various diseases.
摘要翻译： 本发明涉及通式（I）的噻唑烷酮：其生产和用作治疗各种疾病的马球状激酶（Plk）的抑制剂。
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