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1.发明授权2-hetarylthiazole-4-carboxamide derivatives, their preparation and use as pharmaceuticals 有权2-萘基噻唑-4-甲酰胺衍生物，其制备和用作药物公开(公告)号：US08148411B2
公开(公告)日：2012-04-03
申请号：US12331028
申请日：2008-12-09
申请人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
发明人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
IPC分类号： A61K31/4155 , A61K31/426 , C07D277/24
CPC分类号： C07D417/04 , C07D417/14 , C07D495/02
摘要： The present invention relates to 2-hetarylthiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof
摘要翻译： 本发明涉及式（I）的2-噻吨基噻唑-4-甲酰胺衍生物，其作为治疗各种病症的药物的用途及其制备方法
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![Oxo-substituted imidazo[1,2b]pyridazines, their preparation and use as pharmaceuticals](/abs-image/US/2009/04/09/US20090093475A1/abs.jpg.150x150.jpg)
2.发明申请Oxo-substituted imidazo[1,2b]pyridazines, their preparation and use as pharmaceuticals 失效氧代取代的咪唑并[1,2b]哒嗪，其制备和用作药物公开(公告)号：US20090093475A1
公开(公告)日：2009-04-09
申请号：US11765638
申请日：2007-06-20
申请人： Olaf PRIEN , Knut Eis , Benjamin Bader , Judith Guenther , Arne Von Bonin
发明人： Olaf PRIEN , Knut Eis , Benjamin Bader , Judith Guenther , Arne Von Bonin
IPC分类号： A61K31/5377 , C07D487/04 , A61P37/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P3/10 , A61K31/5025
CPC分类号： C07D487/04
摘要： The invention relates to novel inhibitors of kinases of the general formula (I): in which Q and R1 are defined in the claims, method for preparing such inhibitors, intermediates for preparing such inhibitors and uses of such inhibitors.
摘要翻译： 本发明涉及通式（I）的新型激酶抑制剂：其中Q和R 1在权利要求书中定义，制备这种抑制剂的方法，制备这种抑制剂的中间体和这种抑制剂的用途。
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3.发明授权Quinazoline derivatives, their preparation, their use, and medicaments comprising them 失效喹唑啉衍生物，它们的制备方法，用途和包含它们的药物公开(公告)号：US07741333B2
公开(公告)日：2010-06-22
申请号：US11766232
申请日：2007-06-21
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic E. A. Brittain
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic E. A. Brittain
IPC分类号： A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D513/04 , C07D239/70 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a quinazoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹唑啉衍生物：其中R1，R2，X，Y和Z在说明书和权利要求中表示，通式（A）的化合物用于 各种病症的治疗，以及通式（A）的化合物的制备。
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4.发明申请NOVEL 2-HETARYLTHIAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS PHARMACEUTICALS 有权新型2-炔丙基-4-羧酰胺衍生物，其制备和用作药物公开(公告)号：US20090203715A1
公开(公告)日：2009-08-13
申请号：US12331028
申请日：2008-12-09
申请人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
发明人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
IPC分类号： A61K31/4965 , C07D417/04 , A61K31/4439 , C07D417/14 , A61K31/444 , A61K31/4365 , C07D471/02
CPC分类号： C07D417/04 , C07D417/14 , C07D495/02
摘要： The present invention relates to 2-hetarylthiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof
摘要翻译： 本发明涉及式（I）的2-噻吨基噻唑-4-甲酰胺衍生物，其作为治疗各种病症的药物的用途及其制备方法
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5.发明申请NOVEL 2-SUBSTITUTED TIAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS PHARMACEUTICALS 有权新型2-取代的噻唑-4-羧酰胺衍生物，其制备和用作药物公开(公告)号：US20090149517A1
公开(公告)日：2009-06-11
申请号：US12330696
申请日：2008-12-09
申请人： Ulrich Bothe , Ame Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
发明人： Ulrich Bothe , Ame Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
IPC分类号： A61K31/427 , C07D417/14
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention relates to 2-substituted thiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof
摘要翻译： 本发明涉及式（I）的2-取代噻唑-4-甲酰胺衍生物，其用作治疗各种疾病的药物的用途及其制备方法
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6.发明申请QUINAZOLINE DERIVATIVES, THEIR PREPARATION, THEIR USE, AND MEDICAMENTS COMPRISING THEM 失效喹诺酮衍生物，其制备，其使用和药物包括它们公开(公告)号：US20080019922A1
公开(公告)日：2008-01-24
申请号：US11766232
申请日：2007-06-21
申请人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic Brittain
发明人： Olaf Prien , Knut Eis , Wolfgang Schwede , Judith Guenther , Dieter Zopf , Dominic Brittain
IPC分类号： A61K49/04 , A61K31/495 , A61P9/00 , C07D239/72
CPC分类号： C07D513/04 , C07D239/70 , C07D487/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to a quinazoline derivative having the general formula (A): in which R1, R2, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译： 本发明涉及具有通式（A）的喹唑啉衍生物：其中R 1，R 2，X，Y和Z在说明书中表示， 权利要求书中，使用通式（A）的化合物治疗各种病症，以及制备通式（A）的化合物。
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7.发明申请Thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents 审中-公开没有碱性氮的噻唑烷酮，其生产和用作药剂公开(公告)号：US20070010566A1
公开(公告)日：2007-01-11
申请号：US11410285
申请日：2006-04-25
申请人： Olaf Prien , Volker Schulze , Knut Eis , Lars Wortmann , Dirk Kosemund , Gerhard Siemeister , Uwe Eberspaecher , Judith Guenther , Dominic Brittain
发明人： Olaf Prien , Volker Schulze , Knut Eis , Lars Wortmann , Dirk Kosemund , Gerhard Siemeister , Uwe Eberspaecher , Judith Guenther , Dominic Brittain
IPC分类号： A61K31/427 , C07D417/02
CPC分类号： C07D277/34 , C07D417/06
摘要： The invention relates to thiazolidones of general formula (I) as welt as to their production and to their use as inhibitors of the polo-like kinase (Plk) for treating various diseases, as welt as to intermediate products for the production of the compounds according to the invention.
摘要翻译： 本发明涉及通式（I）的噻唑烷酮，其生产方式及其用作治疗各种疾病的polo样激酶（Plk）的抑制剂的用途，如用于生产化合物的中间产物 涉及本发明。
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8.发明授权2-arylthiazole-4-carboxamide derivatives, their preparation and use as pharmaceuticals 有权2-芳基噻唑-4-甲酰胺衍生物，它们的制备和用作药物公开(公告)号：US08163739B2
公开(公告)日：2012-04-24
申请号：US12331775
申请日：2008-12-10
申请人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
发明人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
IPC分类号： A61K31/535 , A61K31/425
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D495/04
摘要： The present invention relates to 2-arylthiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof
摘要翻译： 本发明涉及式（I）的2-芳基噻唑-4-甲酰胺衍生物，其作为治疗各种病症的药物的用途及其制备方法
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9.发明申请SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY 审中-公开用于治疗与增殖细胞激酶活性相关的超增殖性疾病和疾病的替代苯甲酰苯胺衍生物公开(公告)号：US20110071125A1
公开(公告)日：2011-03-24
申请号：US12599641
申请日：2008-05-09
申请人： Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
发明人： Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
IPC分类号： A61K31/4178 , C12N9/99 , A61K31/397 , A61K31/535 , A61K31/4965 , A61K31/445 , A61K31/425 , A61K31/385 , A61K31/17 , A61K31/165 , C07D295/12 , C07D241/04 , C07D211/30 , C07D277/04 , C07D403/12 , C07D327/04 , C07C273/00 , C07C233/00 , A61P35/00 , A61P27/12
CPC分类号： C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要： This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及新的取代的苯基氨基苯化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。
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10.发明授权2-substituted thiazole-4-carboxamide derivatives, their preparation and use as pharmaceuticals 有权2-取代的噻唑-4-甲酰胺衍生物，其制备和用作药物公开(公告)号：US07897626B2
公开(公告)日：2011-03-01
申请号：US12330696
申请日：2008-12-09
申请人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bömer , Judith Guenther
发明人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bömer , Judith Guenther
IPC分类号： A61K31/4155 , A61K31/426 , C07D277/24
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention relates to 2-substituted thiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof
摘要翻译： 本发明涉及式（I）的2-取代噻唑-4-甲酰胺衍生物，其用作治疗各种疾病的药物的用途及其制备方法
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