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    Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
    3.
    发明申请
    Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof 有权
    与心血管疾病和药物反应相关的遗传多态性，检测方法及其应用

    公开(公告)号：US20070072821A1

    公开(公告)日：2007-03-29

    申请号：US11526137

    申请日：2006-09-22

    申请人： Olga Iakoubova ,  James Devlin

    发明人： Olga Iakoubova ,  James Devlin

    IPC分类号： A61K31/70

    CPC分类号： C12Q1/6883 ,  A61K31/70 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/172

    摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

    摘要翻译： 本发明基于与心血管疾病特别是急性冠状动脉事件（例如心肌梗死和中风）相关的遗传多态性的发现，以及与具有心血管疾病的个体的反应性相关的遗传多态性与该疾病的治疗相关 他汀 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。

    Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
    5.
    发明授权
    Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof 有权
    与心血管疾病和药物反应相关的遗传多态性，检测方法及其应用

    公开(公告)号：US07799530B2

    公开(公告)日：2010-09-21

    申请号：US11526137

    申请日：2006-09-22

    申请人： Olga Iakoubova ,  James Devlin

    发明人： Olga Iakoubova ,  James Devlin

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  A61K31/70 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/172

    摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual having a cardiovascular disorder to treatment of the disorder with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

    摘要翻译： 本发明基于与心血管疾病特别是急性冠状动脉事件（例如心肌梗死和中风）相关的遗传多态性的发现，以及与具有心血管疾病的个体的反应性相关的遗传多态性与该疾病的治疗相关 他汀 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。

    Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
    6.
    发明申请
    Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof 审中-公开
    与心肌梗死相关的遗传多态性，检测方法及其应用

    公开(公告)号：US20070042382A1

    公开(公告)日：2007-02-22

    申请号：US10796307

    申请日：2004-03-10

    申请人： Michele Cargill ,  James Devlin ,  Olga Iakoubova ,  Dov Shiffman

    发明人： Michele Cargill ,  James Devlin ,  Olga Iakoubova ,  Dov Shiffman

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

    摘要翻译： 本发明基于与心肌梗塞相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。

    Genetic polymorphisms associated with vascular, methods of detection and uses thereof
    9.
    发明申请
    Genetic polymorphisms associated with vascular, methods of detection and uses thereof 审中-公开
    与血管相关的遗传多态性，检测方法及其用途

    公开(公告)号：US20050287559A1

    公开(公告)日：2005-12-29

    申请号：US11124368

    申请日：2005-05-09

    申请人： Michele Cargill ,  James Devlin ,  May Luke

    发明人： Michele Cargill ,  James Devlin ,  May Luke

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156

    摘要： The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases and in particular coronary artery disease and stenosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

    摘要翻译： 本发明基于与血管疾病特别是冠状动脉疾病和狭窄相关的遗传多态性的发现。 特别地，本发明涉及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用的方法 用于检测的试剂。