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公开(公告)号:US20110195929A1
公开(公告)日:2011-08-11
申请号:US13057557
申请日:2009-08-04
申请人: Olivier De Moor , Graeme Horne , Penny Jane Middleton , Frank Schroer , Stephen Paul Wren , Maria Ines Passos Eleuterio , Renate Van Well , Colin Richard Dorgan , Francis Xavier Wilson , Robert Nash , Richard Storer , Graham Michael Wynne , Alan Geoffrey Roach , Akane Kawamura , Jonathon Mark Tinsley
发明人: Olivier De Moor , Graeme Horne , Penny Jane Middleton , Frank Schroer , Stephen Paul Wren , Maria Ines Passos Eleuterio , Renate Van Well , Colin Richard Dorgan , Francis Xavier Wilson , Robert Nash , Richard Storer , Graham Michael Wynne , Alan Geoffrey Roach , Akane Kawamura , Jonathon Mark Tinsley
IPC分类号: A61K31/695 , C07D487/04 , A61K31/407 , C07D207/12 , A61K31/40 , C07D211/46 , A61K31/445 , C07D207/16 , C07D451/06 , A61K31/46 , C07D471/04 , A61K31/437 , C07D405/04 , A61K31/453 , C07D265/32 , A61K31/5375 , C07D491/113 , A61K31/438 , C07D223/08 , A61K31/55 , C07F7/18 , C07D491/056 , A61K31/397 , A61P31/14
CPC分类号: C07H19/16 , A61K31/40 , A61K31/445 , A61K31/70 , A61K31/7016 , A61K31/702
摘要: Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.
摘要翻译: 描述了用于治疗黄病毒感染的各种化合物和方法。 特别地,描述了具有抗病毒活性的阿拉伯糖和/或赖索斯立体化学构型中的生物碱和亚氨基糖。
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2.TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES 审中-公开
标题翻译: 治疗淋巴结储存障碍和其他预防性疾病公开(公告)号:US20110237538A1
公开(公告)日:2011-09-29
申请号:US13057654
申请日:2009-08-04
申请人: Olivier De Moor , Graeme Horne , Penny Jane Middleton , Frank Schroer , Stephen Paul Wren , Maria Ines Passos Eleuterio , Renate Van Well , Colin Richard Dorgan , Francis Xavier Wilson , Robert Nash , Richard Storer , Graham Michael Wynne , Alan Geoffrey Roach , Akane Kawamura , Jonathon Mark Tinsley
发明人: Olivier De Moor , Graeme Horne , Penny Jane Middleton , Frank Schroer , Stephen Paul Wren , Maria Ines Passos Eleuterio , Renate Van Well , Colin Richard Dorgan , Francis Xavier Wilson , Robert Nash , Richard Storer , Graham Michael Wynne , Alan Geoffrey Roach , Akane Kawamura , Jonathon Mark Tinsley
IPC分类号: A61K31/7028 , A61K31/407 , A61K31/445 , A61K31/439 , A61K31/55 , A61K31/40 , A61K31/404 , A61K31/47 , A61K31/495 , A61P3/10 , A61P9/00 , A61P25/00 , A61P19/02 , A61P35/00
CPC分类号: A61K31/40 , A61K31/445 , A61K31/70 , A61K31/7016 , A61K31/702
摘要: Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-glucosidase; (c) glucocerebrosidase; (d) alpha-Galactosidase A; (e) Acid beta-galactosidase; (f) beta-Hexosaminidase A; (g) beta-Hexosaminidase B; (h) Acid sphingomyelinase; (i) Galactocerebrosidase; (j) Acid ceramidase; (k) Arylsulfatase A; (l) alpha-L-Iduronidase; (m) Iduronate-2-sulfatase; (n) Heparan N-sulfatase; (o) alpha-N-Acetylglucosaminidase; (p) Acetyl-CoA: alpha-glucosaminide N-acetyltransferase; (q) N-Acetylglucosamine-6-sulfate sulfatase; (r) N-Acetylgalactosamine-6-sulfate sulfatase; (s) Acid beta-galactosidase; (t) Arylsulfatase B; (u) beta-Glucuronidase; (v) Acid alpha-mannosidase; (w) Acid beta-mannosidase; (x) Acid alpha-L-fucosidase; (y) Sialidase; and (z) alpha-N-acetylgalactosaminidase.
摘要翻译: 描述了各种化合物,特别是亚氨基糖苷,以及用于治疗蛋白酶抑制疾病,特别是溶酶体储存障碍的方法。 该化合物可以是选自以下的酶的药代动力学:(a)酸性α-葡糖苷酶; (b)酸性β-葡糖苷酶; (c)葡糖脑苷脂酶; (d)α-半乳糖苷酶A; (e)酸性β-半乳糖苷酶; (f)β-己糖胺酶A; (g)β-己糖淀粉酶B; (h)酸性鞘磷脂酶; (i)半乳糖脑苷脂酶; (j)酸性神经酰胺酶; (k)芳基硫酸酯酶A; (1)α-L-阿索非糖苷酶; (m)伊曲红素-2-硫酸酯酶; (n)肝素N-硫酸酯酶; (o)α-N-乙酰葡糖胺酶; (p)乙酰CoA:α-葡糖胺N-乙酰转移酶; (q)N-乙酰葡糖胺-6-硫酸酯硫酸酯酶; (r)N-乙酰基半乳糖胺-6-硫酸酯硫酸酯酶; 酸性β-半乳糖苷酶; (t)芳基硫酸酯酶B; (u)β-葡糖苷酸酶; (v)酸性α-甘露糖苷酶; (w)酸性β-甘露糖苷酶; (x)酸性α-L-岩藻糖苷酶; (y)唾液酸酶; 和(z)α-N-乙酰半乳糖胺酶。
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公开(公告)号:US20100317690A1
公开(公告)日:2010-12-16
申请号:US12744029
申请日:2008-11-20
申请人: Akane Kawamura , Alan Geoffrey Roach , Francis Xavier Wilson , Jonathon Mark Tinsley , Robert Nash , Richard Storer
发明人: Akane Kawamura , Alan Geoffrey Roach , Francis Xavier Wilson , Jonathon Mark Tinsley , Robert Nash , Richard Storer
IPC分类号: A61K31/46 , A61K31/403 , A61K31/4015 , A61K31/435 , A61K31/445 , C07D487/02 , C07D207/12 , C07D207/24 , C07D451/06 , C07D455/02 , C07D211/40 , A61P43/00 , A61P3/00
CPC分类号: A61K31/40 , A61K31/403 , A61K31/4425 , A61K31/445 , A61K31/55
摘要: Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular, polyhydroxylated alkaloids and imino sugars which are pharmacoperones of an enzyme and which do not bind to a catalytic site of said enzyme are described.
摘要翻译: 描述了用于治疗由异常蛋白质折叠引起的疾病的各种化合物和方法,包括特别是溶酶体贮积病。 特别地,描述了作为酶的药物操作子并且不结合所述酶的催化位点的多羟基化生物碱和亚氨基糖。
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