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1.发明授权公开(公告)号：US08986682B2
公开(公告)日：2015-03-24
申请号：US13278682
申请日：2011-10-21
申请人： Olle Hernell , Birgitta Olsson , Patrik Strömberg , Lennart Svensson , Kristina Timdahl , Mårten Vågerö , Maria Öhman
发明人： Olle Hernell , Birgitta Olsson , Patrik Strömberg , Lennart Svensson , Kristina Timdahl , Mårten Vågerö , Maria Öhman
CPC分类号： A61K38/465 , A23C9/1216 , A23C9/206 , A23L29/06 , A23L33/12 , A23L33/40 , A23V2002/00 , C12Y301/01003 , A23V2200/08 , A23V2250/54 , A23V2300/50
摘要： The present invention relates to a method to increase the absorption by a human infant of at least one unsaturated fatty acid, said method comprising the enteral administration to said infant of recombinant human bile-salt-stimulated lipase (rhBSSL). In another aspect the invention also relates to a method to improve the visual and/or cognitive development of a human infant, said method comprising the enteral administration to said infant of rhBSSL. Such methods have particular utility for preterm human infants, particular those in medical need of increasing their absorption of or availability to such unsaturated fatty acids. In further aspects, the invention relates to kits, packaged-pharmaceutical-products, recombinant human bile-salt-stimulated lipase and pharmaceutical compositions, in each case useful for increasing the absorption by a human infant of at least one unsaturated fatty acid, or for increasing the visual and/or cognitive development of a human infant.
摘要翻译： 本发明涉及一种增加人类婴幼儿至少一种不饱和脂肪酸吸收的方法，所述方法包括向所述婴儿重组人胆汁盐刺激的脂肪酶（rhBSSL）进行肠内施用。 在另一方面，本发明还涉及一种改善人类婴儿的视觉和/或认知发育的方法，所述方法包括对所述婴儿的rhBSSL的肠内施用。 这些方法对于早产儿的婴儿具有特别的用途，特别是在医学上需要增加其对这种不饱和脂肪酸的吸收或可用性的这些方法。 在另外的方面，本发明涉及试剂盒，包装的药物产品，重组人胆汁盐刺激的脂肪酶和药物组合物，在每种情况下都可用于增加人类婴幼儿至少一种不饱和脂肪酸的吸收，或用于 增加人类婴儿的视觉和/或认知发育。
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2.发明申请公开(公告)号：US20120100127A1
公开(公告)日：2012-04-26
申请号：US13278682
申请日：2011-10-21
申请人： Olle Hernell , Birgitta Olsson , Patrik Strömberg , Lennart Svensson , Kristina Timdahl , Mårten Vågerö , Maria Öhman
发明人： Olle Hernell , Birgitta Olsson , Patrik Strömberg , Lennart Svensson , Kristina Timdahl , Mårten Vågerö , Maria Öhman
CPC分类号： A61K38/465 , A23C9/1216 , A23C9/206 , A23L29/06 , A23L33/12 , A23L33/40 , A23V2002/00 , C12Y301/01003 , A23V2200/08 , A23V2250/54 , A23V2300/50
摘要： The present invention relates to a method to increase the absorption by a human infant of at least one unsaturated fatty acid, said method comprising the enteral administration to said infant of recombinant human bile-salt-stimulated lipase (rhBSSL). In another aspect the invention also relates to a method to improve the visual and/or cognitive development of a human infant, said method comprising the enteral administration to said infant of rhBSSL. Such methods have particular utility for preterm human infants, particular those in medical need of increasing their absorption of or availability to such unsaturated fatty acids. In further aspects, the invention relates to kits, packaged-pharmaceutical-products, recombinant human bile-salt-stimulated lipase and pharmaceutical compositions, in each case useful for increasing the absorption by a human infant of at least one unsaturated fatty acid, or for increasing the visual and/or cognitive development of a human infant.
摘要翻译： 本发明涉及一种增加人类婴幼儿至少一种不饱和脂肪酸吸收的方法，所述方法包括向所述婴儿重组人胆汁盐刺激的脂肪酶（rhBSSL）进行肠内施用。 在另一方面，本发明还涉及一种改善人类婴儿的视觉和/或认知发育的方法，所述方法包括对所述婴儿的rhBSSL的肠内施用。 这些方法对于早产儿的婴儿具有特别的用途，特别是在医学上需要增加其对这种不饱和脂肪酸的吸收或可用性的这些方法。 在另外的方面，本发明涉及试剂盒，包装的药物产品，重组人胆汁盐刺激的脂肪酶和药物组合物，在每种情况下都可用于增加人类婴幼儿至少一种不饱和脂肪酸的吸收，或用于 增加人类婴儿的视觉和/或认知发育。
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公开(公告)号：US20120100126A1
公开(公告)日：2012-04-26
申请号：US13278662
申请日：2011-10-21
申请人： Olle Hernell , Birgitta Olsson , Patrik Strömberg , Lennart Svensson , Kristina Timdahl , Mårten Vågerö , Maria Öhman
发明人： Olle Hernell , Birgitta Olsson , Patrik Strömberg , Lennart Svensson , Kristina Timdahl , Mårten Vågerö , Maria Öhman
CPC分类号： A61K38/465 , A23L5/00 , A23L33/17 , A23L33/40 , A23V2002/00 , C12Y301/01003 , C12Y301/01013
摘要： The present invention relates to a method to increase the growth velocity of a human infant, said method comprising the enteral administration to said infant of recombinant human bile-salt-stimulated lipase (rhBSSL). Such method has particular utility for underweight or preterm human infants, particular those in medical need of increasing their growth velocity. The invention also relates to compositions, including infant feeds, kits, packaged-pharmaceutical-products and pharmaceutical compositions, and also to methods to prepare infant feeds. In another aspect, the present invention relates to methods to: (X) protect the small bowel mucosa of a human infant from damage; to (Y) protect an immature intestinal epithelium of a human infant from the deleterious effects of incompletely digested and/or excess fat and/or lipid; and/or to (Z) limit accumulation of incompletely digested and/or excess fat and/or lipid in the ileum of a human infant; said methods in each case comprising the step of enteral administration of rhBSSL.
摘要翻译： 本发明涉及一种增加人类婴儿生长速度的方法，所述方法包括向所述婴儿重组人胆汁盐刺激的脂肪酶（rhBSSL）进行肠内给药。 这种方法对于体重不足或早产儿的婴儿特别有用，特别是医疗需要增加其生长速度的方法。 本发明还涉及组合物，包括婴儿饲料，试剂盒，包装的药物产品和药物组合物，以及制备婴儿饲料的方法。 另一方面，本发明涉及以下方法：（X）保护人类婴儿的小肠粘膜免受损伤; 至（Y）保护人类婴幼儿的未成熟肠上皮细胞不完全消化和/或过量脂肪和/或脂质的有害作用; 和/或（Z）限制人类婴儿回肠中不完全消化和/或多余的脂肪和/或脂质的积累; 所述方法在每种情况下包括rhBSSL的肠内给药步骤。
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公开(公告)号：US08986759B2
公开(公告)日：2015-03-24
申请号：US13278662
申请日：2011-10-21
申请人： Olle Hernell , Birgitta Olsson , Patrik Strömberg , Lennart Svensson , Kristina Timdahl , M{hacek over (a)}rten Vågerö , Maria Öhman
发明人： Olle Hernell , Birgitta Olsson , Patrik Strömberg , Lennart Svensson , Kristina Timdahl , M{hacek over (a)}rten Vågerö , Maria Öhman
CPC分类号： A61K38/465 , A23L5/00 , A23L33/17 , A23L33/40 , A23V2002/00 , C12Y301/01003 , C12Y301/01013
摘要： The present invention relates to a method to increase the growth velocity of a human infant, said method comprising the enteral administration to said infant of recombinant human bile-salt-stimulated lipase (rhBSSL). Such method has particular utility for underweight or preterm human infants, particular those in medical need of increasing their growth velocity. The invention also relates to compositions, including infant feeds, kits, packaged-pharmaceutical-products and pharmaceutical compositions, and also to methods to prepare infant feeds. In another aspect, the present invention relates to methods to: (X) protect the small bowel mucosa of a human infant from damage; to (Y) protect an immature intestinal epithelium of a human infant from the deleterious effects of incompletely digested and/or excess fat and/or lipid; and/or to (Z) limit accumulation of incompletely digested and/or excess fat and/or lipid in the ileum of a human infant; said methods in each case comprising the step of enteral administration of rhBSSL.
摘要翻译： 本发明涉及一种增加人类婴儿生长速度的方法，所述方法包括向所述婴儿重组人胆汁盐刺激的脂肪酶（rhBSSL）进行肠内给药。 这种方法对于体重不足或早产儿的婴儿特别有用，特别是医疗需要增加其生长速度的方法。 本发明还涉及组合物，包括婴儿饲料，试剂盒，包装的药物产品和药物组合物，以及制备婴儿饲料的方法。 另一方面，本发明涉及以下方法：（X）保护人类婴儿的小肠粘膜免受损伤; 至（Y）保护人类婴幼儿的未成熟肠上皮细胞不完全消化和/或过量脂肪和/或脂质的有害作用; 和/或（Z）限制人类婴儿回肠中不完全消化和/或多余的脂肪和/或脂质的积累; 所述方法在每种情况下包括rhBSSL的肠内给药步骤。
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公开(公告)号：US09301932B2
公开(公告)日：2016-04-05
申请号：US14129090
申请日：2012-06-20
申请人： Lennart Svensson , Hans Sidén
发明人： Lennart Svensson , Hans Sidén
摘要： The invention concerns a liquid pharmaceutical formulation suitable for oral administration, comprising a suspension of an effective amount of micronized 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (nitisinone); and citric acid buffer having a pH in the range of 2.5 to 3.5. The formulation is useful in the treatment of disorders and diseases in which inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD) is desirable, e.g. in hereditary tyrosinaemia type I.
摘要翻译： 本发明涉及适于口服给药的液体药物制剂，其包含有效量的微粉化2-（2-硝基-4-三氟甲基苯甲酰基）-1,3-环己二酮（硝基苯酮）的悬浮液; 和柠檬酸缓冲液，pH在2.5至3.5的范围内。 该制剂可用于治疗其中需要抑制4-羟基苯基丙酮酸双加氧酶（HPPD）的疾病和疾病，例如， 在I型遗传性酪氨酸血症
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公开(公告)号：US07650771B2
公开(公告)日：2010-01-26
申请号：US12003305
申请日：2007-12-21
申请人： Lennart Svensson
发明人： Lennart Svensson
CPC分类号： B01J3/04 , B01J19/002 , B01J2219/002 , B01J2219/00213 , B01J2219/00225 , B01J2219/00268 , B30B15/0094 , B30B15/04 , B30B15/042
摘要： A high-pressure press includes a pressure vessel surrounded by a force-absorbing press frame. The high-pressure press also includes a detection structure for detecting changes in length of at least one column comprised in the press frame, the changes in length depending on the pressure inside the pressure vessel. The detection structure includes a limit switch, which is adapted to detect if the change in length of the column has reached a threshold value and, in that case, interrupt a pressing operation in progress and reduce the pressure inside the pressure vessel.
摘要翻译： 高压压机包括由力吸收压力机框架包围的压力容器。 高压压机还包括用于检测包括在压机框架中的至少一列的长度变化的检测结构，其长度变化取决于压力容器内的压力。 检测结构包括限位开关，其适于检测柱的长度变化是否已经达到阈值，并且在这种情况下，中断正在进行的按压操作并且降低压力容器内部的压力。
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公开(公告)号：US20090038487A1
公开(公告)日：2009-02-12
申请号：US12003305
申请日：2007-12-21
申请人： Lennart Svensson
发明人： Lennart Svensson
IPC分类号： B30B15/26
CPC分类号： B01J3/04 , B01J19/002 , B01J2219/002 , B01J2219/00213 , B01J2219/00225 , B01J2219/00268 , B30B15/0094 , B30B15/04 , B30B15/042
摘要： A high-pressure press includes a pressure vessel surrounded by a force-absorbing press frame. The high-pressure press also includes a detection structure for detecting changes in length of at least one column comprised in the press frame, the changes in length depending on the pressure inside the pressure vessel. The detection structure includes a limit switch, which is adapted to detect if the change in length of the column has reached a threshold value and, in that case, interrupt a pressing operation in progress and reduce the pressure inside the pressure vessel.
摘要翻译： 高压压机包括由吸力压力机架包围的压力容器。 高压压机还包括用于检测包括在压机框架中的至少一列的长度变化的检测结构，其长度变化取决于压力容器内的压力。 检测结构包括限位开关，其适于检测柱的长度变化是否已经达到阈值，并且在这种情况下，中断正在进行的按压操作并且降低压力容器内部的压力。
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公开(公告)号：US4280308A
公开(公告)日：1981-07-28
申请号：US72636
申请日：1979-09-06
申请人： Lennart Svensson
发明人： Lennart Svensson
CPC分类号： E04B1/7046 , E04C3/02 , E04C2003/023
摘要： A lintel for supporting arches over doors, windows and other openings in a wall. The lintel is made of relatively thin sheet metal and has at least one load-carrying shank (5;12,13;19,20), so that the lintel in spite of its thin construction can carry great loads during the walling of the arch. The shank or each shank is provided with a longitudinally extending material weakening (6), e.g. a series of slots, perforations, a groove or similar. Said material weakening forms a fracture indication along which the shank can be folded or broken off, when the motar has set and brickwork has become self-supporting.
摘要翻译： 用于在墙壁上的门，窗户和其他开口上支撑拱门的楣板。 楣板由相对薄的金属板制成，并且具有至少一个承载柄（5; 12,13; 19,20），使得楣板尽管其薄的结构可以在拱的围墙期间承载很大的载荷 。 杆或每个柄设置有弱化（6）的纵向延伸的材料，例如。 一系列槽，穿孔，凹槽或类似物。 所述材料削弱形成断裂指示，沿着该断裂指示，柄可以被折叠或折断，当移动已经固定并且砖砌成为自支撑时。
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公开(公告)号：US07310990B2
公开(公告)日：2007-12-25
申请号：US10479682
申请日：2002-07-01
申请人： Lennart Svensson
发明人： Lennart Svensson
CPC分类号： B01J3/04 , B01J19/002 , B01J2219/002 , B01J2219/00213 , B01J2219/00225 , B01J2219/00268 , B30B15/0094 , B30B15/04 , B30B15/042
摘要： A high-pressure press includes a pressure vessel surrounded by a force-absorbing press frame. The high-pressure press also includes a detection structure for detecting changes in length of at least one column comprised in the press frame, the changes in length depending on the pressure inside the pressure vessel. The detection structure includes a limit switch, which is adapted to detect if the change in length of the column has reached a threshold value and, in that case, interrupt a pressing operation in progress and reduce the pressure inside the pressure vessel.
摘要翻译： 高压压机包括由吸力压力机架包围的压力容器。 高压压机还包括用于检测包括在压机框架中的至少一列的长度变化的检测结构，其长度变化取决于压力容器内的压力。 检测结构包括限位开关，其适于检测柱的长度变化是否已经达到阈值，并且在这种情况下，中断正在进行的按压操作并且降低压力容器内部的压力。
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公开(公告)号：USD515675S1
公开(公告)日：2006-02-21
申请号：US29152778
申请日：2001-12-27
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