利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

33 条记录 (耗时 0.063 秒)

    REMOVAL OF VIRULENCE FACTORS THROUGH EXTRACORPOREAL THERAPY
    3.
    发明申请
    REMOVAL OF VIRULENCE FACTORS THROUGH EXTRACORPOREAL THERAPY 审中-公开
    通过超临界治疗去除病毒因子

    公开(公告)号：US20120305482A1

    公开(公告)日：2012-12-06

    申请号：US13577529

    申请日：2011-02-09

    申请人： Keith McCrea ,  Robert S. Ward

    发明人： Keith McCrea ,  Robert S. Ward

    IPC分类号： A61M1/36 ,  B01D15/08

    CPC分类号： A61K31/727 ,  A61M1/362 ,  A61M1/3679

    摘要： A method to remove virulence factors from infected blood by passing the blood through a surface cartridge with immobilized carbohydrates, such as heparin, wherein the virulence factors are toxins released from pathogens such as B. anthracis, S. aureus, and P. aeruginosa.

    摘要翻译： 通过使血液通过具有固定化碳水化合物（例如肝素）的表面柱塞来从感染的血液中除去毒力因子的方法，其中毒力因子是从诸如炭疽杆菌，金黄色葡萄球菌和铜绿假单胞菌的病原体释放的毒素。

    SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS
    4.
    发明申请
    SURFACE MODIFICATION OF POLYMERS VIA SURFACE ACTIVE AND REACTIVE END GROUPS 审中-公开
    通过表面活性和反应性末端组合聚合物的表面改性

    公开(公告)号：US20110293522A1

    公开(公告)日：2011-12-01

    申请号：US13129438

    申请日：2009-11-16

    申请人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Xuwei Jiang ,  Keith Mccrea ,  Scott Curtin

    发明人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Xuwei Jiang ,  Keith Mccrea ,  Scott Curtin

    IPC分类号： A61K49/00 ,  B29C45/00 ,  A61P31/00 ,  A61P7/02 ,  C08G18/83 ,  A61K31/785

    CPC分类号： C08G18/837 ,  A61K2800/61 ,  C08G18/08 ,  C08J7/12 ,  C08J7/14

    摘要： Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties.

    摘要翻译： 聚合物表面改性方法包括以下步骤：在制品制造期间首先形成与聚合物链末端连接的主要反应性端基的表面，然后用生物活性分子，亲水和疏水单体，低聚物或聚合物改性活性表面 以获得特定的表面性质。 或者，多功能偶联剂可用于将主反应性基团与能够与与生物活性分子，亲水和疏水单体，低聚物和聚合物相关的官能团反应的第二反应性基团，以获得特定的表面性质。 本发明涉及将表面活性隔离物连接到聚合物链末端的反应性端基引入表面。 表面活性间隔物允许反应性端基在制造过程中迁移和富集到表面。 本发明提供具有抗血栓形成性质，润滑性，选择性吸附和抗微生物性质的生物界面的医疗装置。

    POLYMERS WITH BIO-FUNCTIONAL SELF ASSEMBLING MONOLAYER ENDGROUPS FOR THERAPEUTIC APPLICATIONS AND BLOOD FILTRATION
    5.
    发明申请
    POLYMERS WITH BIO-FUNCTIONAL SELF ASSEMBLING MONOLAYER ENDGROUPS FOR THERAPEUTIC APPLICATIONS AND BLOOD FILTRATION 审中-公开
    具有生物功能自组装单体终端用于治疗应用和血液过滤的聚合物

    公开(公告)号：US20100179284A1

    公开(公告)日：2010-07-15

    申请号：US12601787

    申请日：2008-05-28

    申请人： Robert S. Ward ,  Keith McCrea ,  Yuan Tian ,  Shanger Wang ,  Larry Jones ,  Anfeng Wang ,  James P. Parakka

    发明人： Robert S. Ward ,  Keith McCrea ,  Yuan Tian ,  Shanger Wang ,  Larry Jones ,  Anfeng Wang ,  James P. Parakka

    IPC分类号： C08B37/10

    CPC分类号： A61K31/785 ,  C08G18/3228 ,  C08G18/3271 ,  C08G18/44 ,  C08G18/5024

    摘要： Medical device, prosthesis, or packaging assembly made up of polymer body comprising at least one polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons, and having x endgroups, x is an integer≧1, E is an endgroup which is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain which has at least 5 repeat units and which can self-assembly with L chains on adjacent molecules of the polymer, and moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight. The polymer body includes plural polymer molecules located internally within the body, at least some of which internal polymer molecules have endgroups that form a surface of the body. The surface endgroups include at least one self-assembling moiety.

    摘要翻译： 由包含至少一种具有式R（LE）x的聚合物的聚合物主体组成的医疗装置，假体或包装组件，其中R是数均分子量为5000至70000道尔顿的聚合物芯，并且具有x个端基， x是整数≥1，E是通过连接L与聚合物核心R共价连接的端基，L是具有至少5个重复单元的二价低聚链，并且可以与L链相邻的分子自组装 聚合物和聚合物中的部分L和/或E可以在组成和/或分子量上彼此相同或不同。 聚合物主体包括位于体内内部的多个聚合物分子，其中至少一些内部聚合物分子具有形成身体表面的端基。 表面端基包括至少一个自组装部分。

    ANTIMICROBIAL POLYMERS AND THEIR USES
    6.
    发明申请
    ANTIMICROBIAL POLYMERS AND THEIR USES 审中-公开
    抗微生物聚合物及其用途

    公开(公告)号：US20110124772A1

    公开(公告)日：2011-05-26

    申请号：US12994836

    申请日：2009-05-26

    申请人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Li Li ,  Keith Mccrea ,  James Parakka ,  Robert L. Jones, JR.

    发明人： Shanger Wang ,  Robert S. Ward ,  Yuan Tian ,  Li Li ,  Keith Mccrea ,  James Parakka ,  Robert L. Jones, JR.

    IPC分类号： C09D175/04 ,  C08G71/04

    CPC分类号： A01N33/12 ,  A01N47/44 ,  A01N25/10 ,  A01N2300/00

    摘要： Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products.

    摘要翻译： 具有非浸出抗菌活性的聚合物及其用作医疗器械的表面涂层或体积树脂。 抗微生物聚合物通过共价键合到聚合物链末端的抗微生物部分或在侧链末端与聚合物主链一起制备。 含抗微生物部分的端基包括表面活性（或表面组装）部分，其促进抗微生物端基在聚合物表面的富集，从而形成抗微生物活性表面。 具有内置抗微生物端基的聚合物可用作散装树脂，作为抗微生物添加剂，或作为医疗器械制造中的感染预防性涂层（例如，导管，血管通路装置，外围线，IV部位，下水道，胃饲和管 ，和其他可植入装置）。 在需要控制生物膜形成的环境中，例如海产品，这些材料也可用作与微生物接触的结构上的抗微生物和防污涂料。

    Control of polymer surface molecular architecture via amphipathic endgroups
    7.
    发明授权
    Control of polymer surface molecular architecture via amphipathic endgroups 有权
    通过两亲性端基控制聚合物表面分子结构

    公开(公告)号：US07884171B2

    公开(公告)日：2011-02-08

    申请号：US12638371

    申请日：2009-12-15

    申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

    发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

    IPC分类号： C08G18/00 ,  C08G77/04 ,  C08G77/22

    CPC分类号： C08G18/6287 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/289 ,  C08G18/5024 ,  C08G18/5039 ,  C08G18/6283 ,  C08G18/6795 ,  C08L75/04 ,  C08G18/3228

    摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.

    摘要翻译： 其表面被包括两亲表面改性部分的端基修饰的聚合物。 聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于 当该重新定位导致界面能量降低时，与身体接触的介质。 两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。 例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。 如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶 。 在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。 还公开了利用这些聚合物的方法和制品。

    Biosensor membrane material
    8.
    发明授权
    Biosensor membrane material 有权
    生物传感器膜材料

    公开(公告)号：US07687586B2

    公开(公告)日：2010-03-30

    申请号：US11404528

    申请日：2006-04-14

    申请人： Robert S. Ward ,  Yuan Tian ,  W. Kenneth Ward ,  Ellen Anderson ,  Jody House

    发明人： Robert S. Ward ,  Yuan Tian ,  W. Kenneth Ward ,  Ellen Anderson ,  Jody House

    IPC分类号： C08G77/42

    CPC分类号： C08G64/18 ,  C08G77/448 ,  C08G77/458

    摘要： Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.

    摘要翻译： 本发明的实施方案提供了用于生物传感器和其它可植入医疗装置和假体的各种多聚体和选择渗透膜。 本发明的实施方案可以提供结构强度和完整性，并且还可以控制葡萄糖，氧气和/或水的流入。 例如，本发明的实施方案可以通过使亲水段的百分比最小化来最小化或减少葡萄糖的流入，从而使吸水的百分比和葡萄糖转运的程度最小化。

    Remote control system
    9.
    发明授权
    Remote control system 失效
    遥控系统

    公开(公告)号：US06633800B1

    公开(公告)日：2003-10-14

    申请号：US09774014

    申请日：2001-01-31

    申请人： Robert S. Ward ,  James M. Law ,  Leif A. Bloomquist

    发明人： Robert S. Ward ,  James M. Law ,  Leif A. Bloomquist

    IPC分类号： G06F700

    CPC分类号： B60W50/02 ,  B60W50/08 ,  G05D1/0038 ,  G05D2201/021

    摘要： An apparatus and method for a control unit which allows for autonomous, manual and tele-operation of mining vehicles. The control unit has a robust system design to withstand the harsh environment of underground mines. The control unit allows a tele-operator, in a remote tele-operator station, to use image and operational data, joysticks and foot pedals to remotely control the mining vehicle. In another aspect, the control unit provides safety features such as supervising its operation for operational errors and providing status, warning and error information to the tele-operator station.

    摘要翻译： 一种用于控制单元的装置和方法，其允许采矿车辆的自动，手动和远程操作。 控制单元具有坚固的系统设计，能够承受地下矿井恶劣的环境。 控制单元允许远程操作员站中的远程操作员使用图像和操作数据，操纵杆和脚踏板远程控制采矿车辆。 在另一方面，控制单元提供安全特征，例如监视其操作错误的操作并向电话操作员站提供状态，警告和错误信息。

    Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecular weight range
    10.
    发明授权
    Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecular weight range 失效
    共聚物和无孔半透膜及其用于渗透预定分子量范围的分子的用途

    公开(公告)号：US5428123A

    公开(公告)日：1995-06-27

    申请号：US52361

    申请日：1993-04-23

    申请人： Robert S. Ward ,  Kathleen A. White

    发明人： Robert S. Ward ,  Kathleen A. White

    IPC分类号： A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  A61L33/06 ,  B01D69/08 ,  B01D71/54 ,  C07K1/34 ,  C08G18/12 ,  C08G18/28 ,  C08G18/44 ,  C08G18/48 ,  C08G18/65 ,  C08G18/66 ,  C08J5/18 ,  C12N11/08 ,  C08G77/04

    CPC分类号： C12N11/08 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  A61L33/068 ,  B01D69/08 ,  B01D71/54 ,  B01D71/80 ,  C07K1/34 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/2885 ,  C08G18/289 ,  C08G18/44 ,  C08G18/4808 ,  C08G18/4833 ,  C08G18/4854 ,  C08G18/6674 ,  C08G18/6685 ,  B01D71/38 ,  B01D71/60

    摘要： A biocompatible, hydrophilic, segmented block polyurethane copolymer which comprises 5 to 45 wt % of a hard segment and 95 to 55 wt % of a soft segment selected from a hydrophilic, hydrophobic and amphipathic oligomer is disclosed. The copolymer is capable of forming a non-porous, semi-permeable film of a tensile strength greater than 300 and up to 10,000 psi, and has an ultimate elongation greater than 300% and up to 1,500% and a water absorption such that the sum of the volume fraction of absorbed water and the hydrophilic volume fraction of the soft segment exceeds about 100% and is up to about 2,000% of the dry polymer volume. The film is permeable to cell nutrients and waste molecules of up to about 6,000 to 600,000 molecular weight and is substantially impermeable to cells and particulate matter. A non-porous, semi-permeable, biocompatible film is formed from the block copolymer of the invention in the form of a flexible sheet or a hollow fiber. Also disclosed is a method of permeating molecules of a predetermined molecular weight range while preventing the passage of larger molecular weight molecules, cells, and condensed phases of matter between two fluids comprising interposing between the two fluids the non-porous film of the invention.

    摘要翻译： 公开了一种生物相容的，亲水的，分段的嵌段聚氨酯共聚物，其包含5至45重量％的硬链段和95至55重量％的选自亲水性，疏水性和两亲性低聚物的软链段。 共聚物能够形成拉伸强度大于300和高达10,000psi的无孔半透膜，并且具有大于300％和高达1500％的极限伸长率，并且吸水率使得总和 的吸收水的体积分数和软链段的亲水体积分数超过约100％，高达干聚合物体积的约2,000％。 该膜对细胞营养物和分子量高达约6,000至600,000的废物分子是可渗透的，并且对于细胞和颗粒物质是基本上不可渗透的。 由本发明的嵌段共聚物以柔性片或中空纤维的形式形成无孔，半渗透的生物相容性膜。 还公开了一种渗透预定分子量范围的分子的方法，同时防止在包含两种流体之间的两种流体之间的较大分子量分子，细胞和物质的冷凝相通过本发明的无孔膜。