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公开(公告)号：US20240228499A1
公开(公告)日：2024-07-11
申请号：US18523642
申请日：2023-11-29
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Do Yeon Kwon , Thomas L. Little , Markus Metz , Peter Kurt Nollert von Specht , Jennifer Tsoung , Sudheer Babu Vaddela , Connor Weidle
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , C07D519/00
摘要： The disclosure provides synthetic compositions useful as inhibitors of mannan-binding lectin-associated serine protease-2 (MASP-2), including compositions that selectively inhibit MASP-2 over thrombin, as well as methods for the manufacture and use thereof.
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公开(公告)号：US20240317682A1
公开(公告)日：2024-09-26
申请号：US18680563
申请日：2024-05-31
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Sara Rebecca Goldstein , Do Yeon Kwon , Thomas L. Little , Markus Metz , Peter Kurt Nollert von Specht , Jennifer Tsoung
IPC分类号： C07D207/16 , C07D403/04 , C07D413/04 , C07D471/04
CPC分类号： C07D207/16 , C07D403/04 , C07D413/04 , C07D471/04
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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公开(公告)号：US12110288B2
公开(公告)日：2024-10-08
申请号：US17112906
申请日：2020-12-04
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Do Yeon Kwon , Thomas L Little , Markus Metz , Peter Kurt Nollert von Specht , Jennifer Tsoung , Jeremiah H. Nguyen , Melinda Davis , Robert Huerta Lemus , Santosh Kumar Keshipeddy , Sara Rebecca Goldstein
IPC分类号： C07D471/04 , A61K31/495 , A61K31/497 , C07D239/545 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D491/048 , C07D495/04 , C07D519/00
CPC分类号： C07D471/04 , C07D239/545 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D491/048 , C07D495/04 , C07D519/00
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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公开(公告)号：US11807641B2
公开(公告)日：2023-11-07
申请号：US17112896
申请日：2020-12-04
申请人： Omeros Corporation
发明人： Michael Cicirelli , Neil S. Cutshall , Jennifer Lynn Gage , Sara Rebecca Goldstein , Santosh Kumar Keshipeddy , Do Yeon Kwon , Robert Huerta Lemus , Thomas L. Little , Markus Metz , Jeremiah H. Nguyen , Peter Kurt Nollert von Specht , Loren Michael Price , Jennifer Tsoung , Sudheer Babu Vaddela
IPC分类号： C07D487/04 , C07D207/16 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D495/04 , C07D471/04 , C07F9/6558 , C07F9/6561
CPC分类号： C07D487/04 , C07D207/16 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/6561 , C07F9/65583
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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公开(公告)号：US12030853B2
公开(公告)日：2024-07-09
申请号：US17112873
申请日：2020-12-04
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Sara Rebecca Goldstein , Do Yeon Kwon , Thomas L. Little , Markus Metz , Peter Kurt Nollert Von Specht , Jennifer Tsoung
IPC分类号： C07D207/16 , A61K31/40 , C07D403/04 , C07D413/04 , C07D471/04
CPC分类号： C07D207/16 , C07D403/04 , C07D413/04 , C07D471/04
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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公开(公告)号：US20240092788A1
公开(公告)日：2024-03-21
申请号：US18461886
申请日：2023-09-06
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Sara Rebecca Goldstein , Santosh Kumar Keshipeddy , Do Yeon Kwon , Robert Huerta Lemus , Thomas L. Little , Markus Metz , Jeremiah H. Nguyen , Peter Kurt Nollert Von Specht , Loren Michael Price , Jennifer Tsoung , Sudheer Babu Vaddela
IPC分类号： C07D487/04 , C07D207/16 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D495/04 , C07F9/6558 , C07F9/6561 , C07D471/04
CPC分类号： C07D487/04 , C07D207/16 , C07D211/60 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D495/04 , C07F9/65583 , C07F9/6561 , C07D471/04
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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公开(公告)号：US20240351980A1
公开(公告)日：2024-10-24
申请号：US18679774
申请日：2024-05-31
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Sara Rebecca Goldstein , Do Yeon Kwon , Thomas L. Little , Markus Metz , Peter Kurt Nollert von Specht , Jennifer Tsoung
IPC分类号： C07D207/16 , C07D403/04 , C07D413/04 , C07D471/04
CPC分类号： C07D207/16 , C07D403/04 , C07D413/04 , C07D471/04
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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公开(公告)号：US11661418B2
公开(公告)日：2023-05-30
申请号：US17112887
申请日：2020-12-04
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Sara Rebecca Goldstein , Santosh Kumar Keshipeddy , Do Yeon Kwon , Robert Huerta Lemus , Thomas L. Little , Markus Metz , Peter Kurt Nollert Von Specht , Loren Michael Price , Jennifer Tsoung
IPC分类号： C07D413/12 , C07D211/60 , C07D401/06 , C07D401/14 , C07D409/12 , C07F9/6561
CPC分类号： C07D413/12 , C07D211/60 , C07D401/06 , C07D401/14 , C07D409/12 , C07F9/6561
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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公开(公告)号：US20230145071A1
公开(公告)日：2023-05-11
申请号：US18060456
申请日：2022-11-30
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Franz A. Gruswitz , Juhienah Khalaf , Thomas L. Little , Markus Metz , Jeremiah H. Nguyen , Peter Kurt Nollert von Specht , Jennifer Tsoung , Michael Cicirelli , Sara Rebecca Goldstein , Santosh Kumar Keshipeddy , Do Yeon Kwon , Robert Huerta Lemus , Sudheer Babu Vaddela
IPC分类号： C07D205/04 , C07D239/96 , C07D401/12 , C07D217/14 , C07C251/24 , C07D213/73 , C07D239/94 , C07D235/30 , C07D207/24 , C07D295/135 , C07C235/88 , C07D295/033 , C07D257/04 , C07D207/16 , C07D207/36 , C07D295/26 , C07D213/81 , C07D417/12 , C07D277/56 , C07D231/44 , C07D471/04 , C07D233/64 , C07D403/12 , C07D249/08 , C07D401/14 , C07D417/14 , C07D471/06 , C07D413/12 , C07D409/14 , C07D495/04 , C07D409/10 , C07D413/14 , C07D401/06 , C07D403/06 , C07D211/60
CPC分类号： C07D205/04 , C07D239/96 , C07D401/12 , C07D217/14 , C07C251/24 , C07D213/73 , C07D239/94 , C07D235/30 , C07D207/24 , C07D295/135 , C07C235/88 , C07D295/033 , C07D257/04 , C07D207/16 , C07D207/36 , C07D295/26 , C07D213/81 , C07D417/12 , C07D277/56 , C07D231/44 , C07D471/04 , C07D233/64 , C07D403/12 , C07D249/08 , C07D401/14 , C07D417/14 , C07D471/06 , C07D413/12 , C07D409/14 , C07D495/04 , C07D409/10 , C07D413/14 , C07D401/06 , C07D403/06 , C07D211/60
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
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公开(公告)号：US11584714B2
公开(公告)日：2023-02-21
申请号：US16425791
申请日：2019-05-29
申请人： Omeros Corporation
发明人： Neil S. Cutshall , Jennifer Lynn Gage , Franz A. Gruswitz , Juhienah Khalaf , Thomas L. Little , Markus Metz , Jeremiah H. Nguyen , Peter Kurt Nollert von Specht , Jennifer Tsoung , Michael Cicirelli , Sara Rebecca Goldstein , Santosh Kumar Keshipeddy , Do Yeon Kwon , Robert Huerta Lemus , Sudheer Babu Vaddela
IPC分类号： C07D211/60 , A61K31/445 , C07D205/04 , C07D239/96 , C07D401/12 , C07D217/14 , C07C251/24 , C07D213/73 , C07D239/94 , C07D235/30 , C07D207/24 , C07D295/135 , C07C235/88 , C07D295/033 , C07D257/04 , C07D207/16 , C07D207/36 , C07D295/26 , C07D213/81 , C07D417/12 , C07D277/56 , C07D231/44 , C07D471/04 , C07D233/64 , C07D403/12 , C07D249/08 , C07D401/14 , C07D417/14 , C07D471/06 , C07D413/12 , C07D409/14 , C07D495/04 , C07D409/10 , C07D413/14 , C07D401/06 , C07D403/06
摘要： The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
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