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    Bipodal-peptide binder
    4.
    发明授权
    Bipodal-peptide binder 有权

    公开(公告)号：US10131693B2

    公开(公告)日：2018-11-20

    申请号：US12999717

    申请日：2009-10-20

    申请人： Sang Yong Jon ,  Sung Hyun Kim ,  Se Ho Park

    发明人： Sang Yong Jon ,  Sung Hyun Kim ,  Se Ho Park

    IPC分类号： C07K14/00 ,  A61K49/00

    摘要： The present invention deals with a bipodal-peptide binder that specifically binds with a target including (a) a structure stabilizing region that includes parallel, antiparallel or parallel and antiparallel amino acid strands wherein interstrand non-covalent bonds are formed; and (b) a target binding region I and a target binding region II that are bonded at both terminals of said structure stabilizing region and respectively include n and m amino acids, and a method of preparing same; the bipodal-peptide binder of the present invention exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a target. The bipodal-peptide binder of the present invention has applications not only in pharmaceuticals but also in in-vivo imaging, in vitro cell imaging, and drug delivery targeting, and can be very usefully employed as an escort molecule.

    BPB-BASED CARGO DELIVERY SYSTEM
    5.
    发明申请
    BPB-BASED CARGO DELIVERY SYSTEM 审中-公开
    基于BPB的货物运输系统

    公开(公告)号：US20120321697A1

    公开(公告)日：2012-12-20

    申请号：US13515163

    申请日：2010-12-03

    申请人： Sang Yong Jon ,  Sung Hyun Kim ,  Seho Park ,  Dongkyu Kim ,  Jinho Park ,  Phei Er Saw

    发明人： Sang Yong Jon ,  Sung Hyun Kim ,  Seho Park ,  Dongkyu Kim ,  Jinho Park ,  Phei Er Saw

    IPC分类号： A61K38/02 ,  A61K9/127 ,  C07K19/00 ,  C07K17/10 ,  B82Y5/00

    CPC分类号： C07K19/00

    摘要： Disclosed are bipodal peptide binder (BPB) based cargo delivery systems wherein cargo is linked to a BPB for delivery into cells or to cell surfaces using target binding ability and specificity of the BPB. The BPB has a structure stabilizing region of parallel or antiparallel amino acid strands or a combination of these strands to induce interstrand non-covalent bonds. The BPB also has target binding regions I and II, each binding to each of both termini of the structure stabilizing region. The number of amino acid residues of regions I and II, respectively, are n and m. The BPB exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a biological target molecule. The BPB based cargo delivery system has applications in drugs, in vivo molecular imaging, in vitro cell imaging, drug delivery targeting and escort molecules.

    摘要翻译： 公开了基于双齿肽粘合剂（BPB）的货物运输系统，其中货物与BPB连接以使用BPB的靶结合能力和特异性递送至细胞或细胞表面。 BPB具有平行或反平行氨基酸链的结构稳定区或这些链的组合以诱导链间非共价键。 BPB还具有靶结合区域I和II，其各自结合结构稳定区域的两个末端中的每一个。 区域I和II的氨基酸残基数分别为n和m。 BPB显示非常低水平（例如，nM水平）的KD值（解离常数），因此对生物靶分子表现出非常高的亲和力。 基于BPB的货物运输系统在药物，体内分子成像，体外细胞成像，药物递送靶向和护送分子中都有应用。

    INTRACELLUAR TARGETING BIPODAL PEPTIDE BINDER
    6.
    发明申请
    INTRACELLUAR TARGETING BIPODAL PEPTIDE BINDER 审中-公开
    腹腔内定向双功能胶原蛋白BINDER BINDER

    公开(公告)号：US20120309934A1

    公开(公告)日：2012-12-06

    申请号：US13515026

    申请日：2010-12-03

    申请人： Sang Yong Jon ,  Sung Hyun Kim ,  Daejin Kim

    发明人： Sang Yong Jon ,  Sung Hyun Kim ,  Daejin Kim

    IPC分类号： C07K19/00

    CPC分类号： C07K19/00 ,  A61K38/00

    摘要： An intracellular targeting bipodal-peptide binder specifically binding to an intracellular target molecule, comprising: (a) a structure-stabilizing region comprising a parallel amino acid strand, an antiparallel amino acid strand or parallel and antiparallel amino acid strands to induce interstrand non-covalent bonds; (b) target binding regions I and II each binding to each of both termini of the structure-stabilizing region, wherein the number of amino acid residues of the target binding region I is n and the number of amino acid residues of the target binding region II is m; and (c) a cell-penetrating peptide (CPP) linked to the structure-stabilizing region, the target binding region I or the target binding region II. Also contemplated is a method for preparing an intracellular targeting bipodal-peptide binder. The bipodal-peptide binder capable of binding to intracellular targets has applications to drugs, in vivo molecular imaging, in vitro cell imaging, drug delivery targeting and escort molecules.

    摘要翻译： 特异性结合细胞内靶分子的细胞内靶向双齿肽结合物，其包含：（a）包含平行氨基酸链，反平行氨基酸链或平行和反平行氨基酸链的结构稳定区，以诱导链间非共价键 债券 （b）靶结合区域I和II各自与结构稳定区域的两个末端各自结合，其中靶结合区域I的氨基酸残基数目为n，靶结合区域的氨基酸残基数 二是m 和（c）与结构稳定区域连接的细胞穿透肽（CPP），靶结合区域I或靶结合区域II。 还考虑了制备细胞内靶向双齿肽粘合剂的方法。 能够结合细胞内靶标的双峰肽结合物可用于药物，体内分子成像，体外细胞成像，药物递送靶向和护送分子。

    Bipodal-Peptide Binder
    7.
    发明申请
    Bipodal-Peptide Binder 审中-公开
    双峰肽粘合剂

    公开(公告)号：US20110152500A1

    公开(公告)日：2011-06-23

    申请号：US12999717

    申请日：2009-10-20

    申请人： Sang Yong Jon ,  Sung Hyun Kim ,  Se Ho Park

    发明人： Sang Yong Jon ,  Sung Hyun Kim ,  Se Ho Park

    IPC分类号： C07K14/00 ,  C40B30/04

    CPC分类号： C07K14/001 ,  A61K49/0032 ,  A61K49/0056

    摘要： The present invention deals with a bipodal-peptide binder that specifically binds with a target including (a) a structure stabilizing region that includes parallel, antiparallel or parallel and antiparallel amino acid strands wherein interstrand non-covalent bonds are formed; and (b) a target binding region I and a target binding region II that are bonded at both terminals of said structure stabilizing region and respectively include n and m amino acids, and a method of preparing same; the bipodal-peptide binder of the present invention exhibits the KD value (dissociation constant) of a very low level (for example, nM level) and, therefore, exhibits very high affinity toward a target. The bipodal-peptide binder of the present invention has applications not only in pharmaceuticals but also in in-vivo imaging, in vitro cell imaging, and drug delivery targeting, and can be very usefully employed as an escort molecule.

    摘要翻译： 本发明涉及与靶标特异性结合的双齿肽粘合剂，包括（a）结构稳定区，其包含平行，反向平行或平行和反平行的氨基酸链，其中形成了链间非共价键; 和（b）在所述结构稳定区的两端键合并分别包含n和m个氨基酸的靶结合区I和靶结合区II及其制备方法。 本发明的双齿 - 肽结合物表现出非常低水平（例如，nM水平）的KD值（解离常数），因此对目标表现出非常高的亲和力。 本发明的双齿肽粘合剂不仅在药物中也具有体内成像，体外细胞成像和药物递送靶向的用途，并且可以非常有用地用作护送分子。