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    Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals
    3.
    发明申请
    Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals 有权
    涂层控释聚合物颗粒作为生物制药的高效口服输送载体

    公开(公告)号：US20080268063A1

    公开(公告)日：2008-10-30

    申请号：US11666908

    申请日：2005-11-04

    申请人： Sangyong Jon ,  Omid C. Farokhazd ,  Robert S. Langer ,  Jianjun Cheng

    发明人： Sangyong Jon ,  Omid C. Farokhazd ,  Robert S. Langer ,  Jianjun Cheng

    IPC分类号： A61K9/14 ,  A61K31/7088 ,  A61K38/28 ,  A61K38/02 ,  A61K39/00

    CPC分类号： A61K9/5138 ,  A61K9/0043 ,  A61K9/0065 ,  A61K9/5036 ,  A61K9/5153 ,  A61K9/5192 ,  A61K38/28

    摘要： A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.

    摘要翻译： 用于将活性剂递送至患者的组合物。 该组合物包括包封活性剂的聚合物芯和围绕该芯设置的粘膜粘附性涂层。 聚合物可以包括共价连接的聚（乙二醇）链，并且可以选择粘膜粘附性涂层以促进颗粒通过肠粘膜的转移。 可以选择聚合物的分子量和交联密度，使得聚合物芯将以预定的时间间隔分解。 在预定时间间隔期间进入系统的药物剂量的分数可以在约0.25％至约25％之间。 组合物可以配制成与药学上可接受的载体组合以产生可食用或可吸入的药物产品的多个纳米颗粒或微粒。

    Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
    4.
    发明授权
    Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals 有权
    涂覆的控释聚合物颗粒作为用于生物药物的高效口服递送载体

    公开(公告)号：US09492400B2

    公开(公告)日：2016-11-15

    申请号：US11666908

    申请日：2005-11-04

    申请人： Sangyong Jon ,  Omid C. Farokhazd ,  Robert S. Langer ,  Jianjun Cheng

    发明人： Sangyong Jon ,  Omid C. Farokhazd ,  Robert S. Langer ,  Jianjun Cheng

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/51 ,  A61K9/00

    CPC分类号： A61K9/5138 ,  A61K9/0043 ,  A61K9/0065 ,  A61K9/5036 ,  A61K9/5153 ,  A61K9/5192 ,  A61K38/28

    摘要： A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.

    摘要翻译： 用于将活性剂递送至患者的组合物。 该组合物包括包封活性剂的聚合物芯和围绕该芯设置的粘膜粘附性涂层。 聚合物可以包括共价连接的聚（乙二醇）链，并且可以选择粘膜粘附性涂层以促进颗粒通过肠粘膜的转移。 可以选择聚合物的分子量和交联密度，使得聚合物芯将以预定的时间间隔分解。 在预定时间间隔期间进入系统的药物剂量的分数可以在约0.25％至约25％之间。 组合物可以配制成与药学上可接受的载体组合以产生可食用或可吸入的药物产品的多个纳米颗粒或微粒。