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1.发明申请公开(公告)号：US20180028496A1
公开(公告)日：2018-02-01
申请号：US15785782
申请日：2017-10-17
发明人： Olena Taratula , Oleh Taratula , Adam Alani
IPC分类号： A61K31/409 , A61K49/00 , A61K41/00
CPC分类号： A61K31/409 , A61K41/0071 , A61K49/0036 , A61K49/0093 , G01N15/14
摘要： Embodiments of a composition comprising a photosensitive compound and a polymer nanoparticle are disclosed herein. The composition may further comprise a targeting moiety. In some embodiments, the photosensitive compound is a phthalocyanine or phthalocyanine derivative, such as a naphthalocyanine. Upon irradiation with near infrared light, the composition may be used as a fluorescent imaging agent and/or as a phototherapeutic agent, such as for photodynamic and/or photothermal therapies. In certain embodiments, the composition is used to treat certain cancers.
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公开(公告)号：US10646472B2
公开(公告)日：2020-05-12
申请号：US15785782
申请日：2017-10-17
发明人： Olena Taratula , Oleh Taratula , Adam Alani
IPC分类号： A61K9/00 , A61K31/409 , A61K41/00 , A61K49/00 , G01N15/14
摘要： Embodiments of a composition comprising a photosensitive compound and a polymer nanoparticle are disclosed herein. The composition may further comprise a targeting moiety. In some embodiments, the photosensitive compound is a phthalocyanine or phthalocyanine derivative, such as a naphthalocyanine. Upon irradiation with near infrared light, the composition may be used as a fluorescent imaging agent and/or as a phototherapeutic agent, such as for photodynamic and/or photothermal therapies. In certain embodiments, the composition is used to treat certain cancers.
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公开(公告)号：US20230338575A1
公开(公告)日：2023-10-26
申请号：US18186606
申请日：2023-03-20
CPC分类号： A61K47/6935 , A61K33/26 , A61K47/6425 , B82Y5/00
摘要： Disclosed herein are embodiments of a nanoparticle suitable for use in providing hyperthermia treatment. The nanoparticle may be a cobalt-doped iron oxide nanoparticle. Also disclosed are compositions comprising the nanoparticle. The composition may further comprise a polymer and/or a targeting moiety. Further disclosed and methods for making the nanoparticle and the composition, and embodiments of a method for using the nanoparticle or a composition thereof. The nanoparticle may be useful for treating cancer, and/or endometriosis.
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公开(公告)号：US10905766B2
公开(公告)日：2021-02-02
申请号：US15984261
申请日：2018-05-18
IPC分类号： A61K47/34 , A61K48/00 , A61K31/7105 , A61K9/00 , C08L77/04 , A61K45/06 , A61K9/51 , A61K38/17 , A61P21/00 , C07K14/47
摘要： mRNA polymer complexes and drug delivery systems are disclosed herein that include a cationic polymer electrostatically complexed to an mRNA molecule that encodes a desired protein. Also disclosed herein are methods of treating as well as methods of slowing the loss of, increasing, and/or maintaining lean muscle mass in a subject, such as using mRNA polymer complexes and drug delivery systems.
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公开(公告)号：US20180303944A1
公开(公告)日：2018-10-25
申请号：US15984261
申请日：2018-05-18
发明人： Oleh Taratula , Canan Schumann , Olena Taratula , Adam W.G. Alani
IPC分类号： A61K47/34 , A61K48/00 , A61K31/7105 , C08L77/04 , A61K9/00
CPC分类号： A61K47/34 , A61K9/0019 , A61K31/7105 , A61K38/16 , A61K38/24 , A61K45/06 , A61K47/00 , A61K48/0058 , A61P21/00 , C07K14/473 , C08L77/04 , C08L2203/02
摘要： mRNA polymer complexes and drug delivery systems are disclosed herein that include a cationic polymer electrostatically complexed to an mRNA molecule that encodes a desired protein. Also disclosed herein are methods of treating as well as methods of slowing the loss of, increasing, and/or maintaining lean muscle mass in a subject, such as using mRNA polymer complexes and drug delivery systems.
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