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公开(公告)号：US08937065B2
公开(公告)日：2015-01-20
申请号：US13491069
申请日：2012-06-07
申请人： Oren M. Becker , Itai Bloch , Efrat Ben-Zeev , Alina Shitrit , Avihai Yacovan , Sharon Gazal , Vered Behar , Alexander Konson , Nili Schutz , Sima Mirilashvili , Gali Golan
发明人： Oren M. Becker , Itai Bloch , Efrat Ben-Zeev , Alina Shitrit , Avihai Yacovan , Sharon Gazal , Vered Behar , Alexander Konson , Nili Schutz , Sima Mirilashvili , Gali Golan
IPC分类号： A61K31/5377 , A61K31/427 , C07D413/14 , C07D417/14 , C07D417/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/113 , C07D491/147 , C07D495/04 , C07D495/22 , C07D513/04
CPC分类号： C07D417/04 , A61K31/427 , A61K31/5377 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/113 , C07D491/147 , C07D495/04 , C07D495/22 , C07D513/04
摘要： The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.
摘要翻译： 本发明涉及用于调节激酶信号级联的一种或多种成分的化合物和方法。
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公开(公告)号：US20120316148A1
公开(公告)日：2012-12-13
申请号：US13491069
申请日：2012-06-07
申请人： Oren M. Becker , Itai Bloch , Efrat Ben-Zeev , Alina Shitrit , Avihai Yacovan , Sharon Gazal , Vered Behar , Alexander Konson , Nili Schutz , Sima Mirilashvili , Gali Golan
发明人： Oren M. Becker , Itai Bloch , Efrat Ben-Zeev , Alina Shitrit , Avihai Yacovan , Sharon Gazal , Vered Behar , Alexander Konson , Nili Schutz , Sima Mirilashvili , Gali Golan
IPC分类号： A61K31/427 , A61K31/496 , A61K31/5377 , A61K31/454 , A61K31/4439 , A61K31/497 , C07D417/04 , C07D491/113 , A61K31/438 , A61K31/55 , C07D495/04 , A61K31/4365 , C07D471/04 , C07D487/04 , A61P35/00 , A61P37/00 , A61P37/06 , A61P29/00 , A61P27/02 , A61P17/06 , A61P19/02 , A61P25/00 , C07D417/14
CPC分类号： C07D417/04 , A61K31/427 , A61K31/5377 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/113 , C07D491/147 , C07D495/04 , C07D495/22 , C07D513/04
摘要： The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.
摘要翻译： 本发明涉及用于调节激酶信号级联的一种或多种成分的化合物和方法。
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公开(公告)号：US08692001B2
公开(公告)日：2014-04-08
申请号：US13281929
申请日：2011-10-26
申请人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
发明人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
IPC分类号： C07D405/02 , A61K31/405
CPC分类号： C07D209/08 , C07D319/18 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
摘要翻译： 本发明涉及磺酰胺化合物和激活PKM2的方法。 所述化合物和方法可用于治疗或预防选自癌症，细胞增殖性疾病，炎症性疾病，代谢紊乱和免疫系统疾病的疾病或病症。
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公开(公告)号：US20120108631A1
公开(公告)日：2012-05-03
申请号：US13281929
申请日：2011-10-26
申请人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
发明人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
IPC分类号： A61K31/404 , C07D319/18 , C07D403/12 , C07D209/08 , A61P37/00 , A61K31/4709 , A61K31/357 , A61P35/00 , A61P29/00 , A61P3/00 , C07D405/12 , C07D405/14
CPC分类号： C07D209/08 , C07D319/18 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
摘要翻译： 本发明涉及磺酰胺化合物和激活PKM2的方法。 所述化合物和方法可用于治疗或预防选自癌症，细胞增殖性疾病，炎性疾病，代谢紊乱和免疫系统疾病的疾病或病症。
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公开(公告)号：US20190002419A1
公开(公告)日：2019-01-03
申请号：US16066971
申请日：2016-12-28
IPC分类号： C07D275/06
摘要： A process for preparing, 1,1,3-Trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: reacting 2-chloro-sulfonyl-terephthalic acid dialkyl ester of formula (II) with ammonia (N H3) or ammonium containing-salt; wherein R represents a branched or non-branched C1-C12 alkyl.
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公开(公告)号：US09422235B2
公开(公告)日：2016-08-23
申请号：US12520061
申请日：2007-12-19
IPC分类号： C07C311/39 , C07C311/48 , C07C311/51 , C07C311/40 , C07D405/12 , C07D471/08 , C07D209/08 , C07D209/48 , C07D213/38 , C07D213/42 , C07D217/04 , C07D319/18 , C07D231/38 , C07D295/12 , C07D295/13 , C07D295/22 , C07D307/14 , C07D307/52 , C07D317/58
CPC分类号： C07C311/39 , C07C311/40 , C07C311/48 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/48 , C07D213/38 , C07D213/42 , C07D217/04 , C07D231/38 , C07D295/12 , C07D295/13 , C07D295/22 , C07D307/14 , C07D307/52 , C07D317/58 , C07D319/18 , C07D405/12 , C07D471/08
摘要： The invention provides sulfonamide compounds of formula (I) as defined herein, pharmaceutical compositions containing the same and methods of treatment using such compounds and pharmaceutical compositions. These compounds have a common wide range of beneficial therapeutic indications, in particular as analgesic and anti-inflammatory agents.
摘要翻译： 本发明提供了如本文所定义的式（I）的磺酰胺化合物，含有其的药物组合物和使用这些化合物和药物组合物的治疗方法。 这些化合物具有普遍广泛的有益治疗适应症，特别是作为止痛剂和抗炎剂。
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公开(公告)号：US20100056528A1
公开(公告)日：2010-03-04
申请号：US12520061
申请日：2007-12-19
IPC分类号： A61K31/18 , C07D295/125 , C07D317/46 , C07C311/16 , C07D307/14 , C07D315/00 , C07D405/12 , A61K31/5375 , A61K31/357 , A61K31/341 , A61K31/472 , A61P29/00 , A61P37/00 , A61P9/00 , A61P27/02 , A61P35/00 , A61P11/00
CPC分类号： C07C311/39 , C07C311/40 , C07C311/48 , C07C311/51 , C07C2601/02 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/48 , C07D213/38 , C07D213/42 , C07D217/04 , C07D231/38 , C07D295/12 , C07D295/13 , C07D295/22 , C07D307/14 , C07D307/52 , C07D317/58 , C07D319/18 , C07D405/12 , C07D471/08
摘要： The invention provides sulfonamide compounds of formula (I) as defined herein, pharmaceutical compositions containing the same and methods of treatment using such compounds and pharmaceutical compositions. These compounds have a common wide range of beneficial therapeutic indications, in particular as analgesic and anti-inflammatory agents.
摘要翻译： 本发明提供了本文定义的式（I）的磺酰胺化合物，含有其的药物组合物和使用这些化合物和药物组合物的治疗方法。 这些化合物具有普遍广泛的有益治疗适应症，特别是作为止痛剂和抗炎剂。
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公开(公告)号：US20200157067A1
公开(公告)日：2020-05-21
申请号：US16066965
申请日：2016-12-28
申请人： Bijukumar Gopinathan Pillai , Sima Mirilashvili , Yaniv Barda , Bhavinkumar P. Hamirani , Bhoopal Meka , Sreedevi Mannam
发明人： Bijukumar Gopinathan Pillai , Sima Mirilashvili , Yaniv Barda , Bhavinkumar P. Hamirani , Bhoopal Meka , Sreedevi Mannam
IPC分类号： C07D275/06 , C07D239/69
摘要： A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III); (b) converting the formed 2-sulfamoyl-terephthalic acid of formula (III) to receive 2-sulfamoyl-terephthalic acid derivative of formula (IV); and (c) reacting the resulting 2-sulfamoyl-terephthalic acid derivative of formula (IV) with ammonia (NH3) or ammonium containing-salt; wherein R represents OR′ or CI and R′ represents a branched or non-branched C1-C12 alkyl.
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公开(公告)号：US11932613B2
公开(公告)日：2024-03-19
申请号：US16994855
申请日：2020-08-17
申请人： Bijukumar Gopinathan Pillai , Sima Mirilashvili , Yaniv Barda , Bhavinkumar P. Hamirani , Bhoopal Meka , Sreedevi Mannam
发明人： Bijukumar Gopinathan Pillai , Sima Mirilashvili , Yaniv Barda , Bhavinkumar P. Hamirani , Bhoopal Meka , Sreedevi Mannam
IPC分类号： C07D239/52 , C07D239/69 , C07D275/06
CPC分类号： C07D275/06 , C07D239/52 , C07D239/69
摘要： A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III); (b) converting the formed 2-sulfamoyl-terephthalic acid of formula (III) to receive 2-sulfonoyl-terephthalic acid derivative of formula (IV); and (c) reacting the resulting 2-sulfamoyl-terephthalic acid derivative of formula (IV) with ammonia (NH3) or ammonium containing-salt; wherein R represents OR′ or CI and R′ represents a branched or non-branched C1-C12 alkyl.
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公开(公告)号：US20210101857A1
公开(公告)日：2021-04-08
申请号：US16500271
申请日：2018-04-03
申请人： Doron Pappo , Shmuel A. Baron , Sima Mirilashvili , Yaniv Barda
发明人： Doron Pappo , Shmuel A. Baron , Sima Mirilashvili , Yaniv Barda
摘要： The present subject matter relates to a process for separating compound (I) from a mixture comprising compound (I). The present subject matter also relates to a process for separating compound (I) from a mixture comprising compound (I) and compound (II).
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