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公开(公告)号：US20220195380A1
公开(公告)日：2022-06-23
申请号：US17491862
申请日：2021-10-01
申请人： Organovo, Inc.
摘要： Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.
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2.发明申请ENGINEERED THREE-DIMENSIONAL SKIN TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME 审中-公开工程三维皮肤组织，其阵列及其制造方法公开(公告)号：US20160122723A1
公开(公告)日：2016-05-05
申请号：US14933822
申请日：2015-11-05
申请人： ORGANOVO, INC.
IPC分类号： C12N5/071
CPC分类号： A61L27/362 , A61L27/50 , A61L27/60 , A61L2300/64 , C12N5/0698 , C12N2502/091 , C12N2502/094 , C12N2502/1323 , C12N2503/06 , C12N2533/54 , C12N2533/74 , C12N2533/90 , C12N2535/00 , G01N33/5044
摘要： Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.
摘要翻译： 公开了生物印迹，三维生物皮肤组织，其包括：包含真皮成纤维细胞的真皮层; 以及表皮层，其包含角质形成细胞，所述表皮层与真皮层接触以形成三维，工程化的生物皮肤组织。 还公开了工程化皮肤组织的阵列和制备工程皮肤组织的方法。
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公开(公告)号：US20180265839A1
公开(公告)日：2018-09-20
申请号：US15765110
申请日：2016-11-09
申请人： Organovo, Inc.
IPC分类号： C12N5/00 , C12N5/071 , C12N5/077 , B41J2/01 , B29C64/112
CPC分类号： C12N5/0068 , B29C64/112 , B29L2031/7532 , B33Y70/00 , B33Y80/00 , B41J2/01 , C12N5/0062 , C12N5/0656 , C12N5/0697 , C12N2502/091 , C12N2502/094 , C12N2523/00 , C12N2533/54 , C12N2539/00
摘要： Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.
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公开(公告)号：US20170130192A1
公开(公告)日：2017-05-11
申请号：US14936580
申请日：2015-11-09
申请人： ORGANOVO, INC.
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , C12N5/0697 , C12N2513/00
摘要： Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.
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5.发明公开公开(公告)号：US20230201420A1
公开(公告)日：2023-06-29
申请号：US18068137
申请日：2022-12-19
申请人： Organovo, Inc. , L'Oreal
发明人： Kelsey Nicole RETTING , Colin M. O'NEILL , Deborah Lynn Greene NGUYEN , Sharon C. PRESNELL , Jessica LANGER , Guive BALOOCH , Elizabeth WU , Julien DEMAUDE
CPC分类号： A61L27/362 , C12N5/0698 , A61L27/50 , A61L27/60 , G01N33/5044 , C12N2502/094 , C12N2502/091 , C12N2502/1323 , C12N2533/90 , C12N2503/06 , C12N2535/00 , C12N2533/54 , C12N2533/74 , A61L2300/64
摘要： Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.
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公开(公告)号：US20220204942A1
公开(公告)日：2022-06-30
申请号：US17695546
申请日：2022-03-15
申请人： Organovo, Inc.
摘要： Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model. Also disclosed are methods of assessing the effect of an agent on intestinal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
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公开(公告)号：US20220204941A1
公开(公告)日：2022-06-30
申请号：US17695538
申请日：2022-03-15
申请人： Organovo, Inc.
摘要： Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model. Also disclosed are methods of assessing the effect of an agent on intestinal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
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公开(公告)号：US20210284967A1
公开(公告)日：2021-09-16
申请号：US16349109
申请日：2017-11-10
申请人： Organovo, Inc.
摘要： Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model. Also disclosed are methods of assessing the effect of an agent on intestinal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
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