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1.发明申请Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same 有权具有对化学引诱物的敏感性增加的干细胞及其产生和使用方法公开(公告)号：US20070172464A1
公开(公告)日：2007-07-26
申请号：US10552331
申请日：2004-04-07
Applicant: Orit Kollet , Tsvee Lapidot
Inventor： Orit Kollet , Tsvee Lapidot
CPC classification number: A61K38/18 , A61K35/28 , A61K38/1833 , A61K38/204 , C12N5/0647 , C12N2501/12 , C12N2501/125 , C12N2501/23 , A61K2300/00
Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.
Abstract translation: 本发明涉及对化学引诱物显示增加的敏感性的干细胞，更具体地涉及产生和使用它们的方法，例如涉及干细胞移植的临床应用。
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2.发明授权Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same 有权具有对化学引诱物的敏感性增加的干细胞及其产生和使用方法公开(公告)号：US08029780B2
公开(公告)日：2011-10-04
申请号：US10552331
申请日：2004-04-07
Applicant: Orit Kollet , Tsvee Lapidot
Inventor： Orit Kollet , Tsvee Lapidot
CPC classification number: A61K38/18 , A61K35/28 , A61K38/1833 , A61K38/204 , C12N5/0647 , C12N2501/12 , C12N2501/125 , C12N2501/23 , A61K2300/00
Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.
Abstract translation: 本发明涉及对化学引诱物显示增加的敏感性的干细胞，更具体地涉及产生和使用它们的方法，例如涉及干细胞移植的临床应用。
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3.发明申请公开(公告)号：US20060251616A1
公开(公告)日：2006-11-09
申请号：US11484772
申请日：2006-07-12
Applicant: Orit Kollet , Tsvee Lapidot
Inventor： Orit Kollet , Tsvee Lapidot
CPC classification number: C07K14/522 , A61K31/513 , A61K31/675 , A61K35/28 , A61K38/00 , A61K38/193 , A61K2300/00
Abstract: The invention relates to transplantation of hematopoietic stem cells (HSC) and/or progenitor cells (HPC) into the liver. More specifically the invention relates to the use of chemokines, preferably SDF-1, for enhancing homing of HSC/HPC to the liver.
Abstract translation: 本发明涉及将造血干细胞（HSC）和/或祖细胞（HPC）移植到肝脏中。 更具体地，本发明涉及趋化因子，优选SDF-1用于增强HSC / HPC归巢到肝脏的用途。
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4.发明申请公开(公告)号：US20080305097A1
公开(公告)日：2008-12-11
申请号：US11576064
申请日：2005-10-27
Applicant: Tsvee Lapidot , Orit Kollet
Inventor： Tsvee Lapidot , Orit Kollet
CPC classification number: A61K38/4873 , A61K2300/00
Abstract: The invention relates to the use of a cathepsin K inhibitor (CTKI) or CTK, a mutein, isoform, fused protein, functional derivative, active fraction, circularly permutated derivative, a salt or inducer thereof in the manufacture of a medicament for treating a disease in which SDF-1 activity and/or concentration is involved with the development and/or course of the disease.
Abstract translation: 本发明涉及组织蛋白酶K抑制剂（CTKI）或CTK，突变蛋白，同种型，融合蛋白，功能衍生物，活性成分，环状置换衍生物，其盐或诱导剂在制备用于治疗疾病的药物中的用途 其中SDF-1活性和/或浓度涉及疾病的发展和/或过程。
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5.发明授权Nucleic acids encoding chimeric interleukin-6 soluble receptor/ligand protein, analogs thereof and uses thereof 有权编码嵌合白细胞介素-6可溶性受体/配体蛋白的核酸，其类似物及其用途公开(公告)号：US07374912B2
公开(公告)日：2008-05-20
申请号：US11688640
申请日：2007-03-20
Applicant: Michel Revel , Judith Chebath , Tsvee Lapidot , Orit Kollet
Inventor： Michel Revel , Judith Chebath , Tsvee Lapidot , Orit Kollet
CPC classification number: C12N15/62 , A61K38/00 , C07K14/5412 , C07K14/7155 , C07K2319/00 , C07K2319/02 , C07K2319/32 , C07K2319/71 , C07K2319/95
Abstract: Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.
Abstract translation: 提供由天然存在形式的可溶性IL-6受体和IL-6融合构建的嵌合蛋白，其可用于治疗癌症和肝脏疾病，增强骨髓移植和治疗其他IL-6相关病症。 。
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Patent Agency Ranking
6.发明授权Stem cells having increased sensitivity to SDF-1 and methods of generating and using same 失效对SDF-1具有增加的敏感性的干细胞及其产生和使用方法公开(公告)号：US08252588B2
公开(公告)日：2012-08-28
申请号：US10552299
申请日：2004-04-07
Applicant: Orit Kollet , Tsvee Lapidot
Inventor： Orit Kollet , Tsvee Lapidot
CPC classification number: C12N5/0647 , A61K35/16 , A61K35/28 , A61K38/4886 , A61K2035/124 , C12N2501/12 , C12N2501/125 , C12N2501/23 , C12N2501/70
Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.
Abstract translation: 本发明涉及对化学引诱物显示增加的敏感性的干细胞，更具体地涉及产生和使用它们的方法，例如涉及干细胞移植的临床应用。
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7.发明申请Chimeric Interleukin-6 Soluble Receptor/Ligand Protein, Analogs Thereof and Uses Thereof 有权嵌合白细胞介素-6可溶性受体/配体蛋白，其类似物及其用途公开(公告)号：US20070172455A1
公开(公告)日：2007-07-26
申请号：US11688640
申请日：2007-03-20
Applicant: Michel Revel , Judith Chebath , Tsvee Lapidot , Orit Kollet
Inventor： Michel Revel , Judith Chebath , Tsvee Lapidot , Orit Kollet
CPC classification number: C12N15/62 , A61K38/00 , C07K14/5412 , C07K14/7155 , C07K2319/00 , C07K2319/02 , C07K2319/32 , C07K2319/71 , C07K2319/95
Abstract: Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.
Abstract translation: 提供由天然存在形式的可溶性IL-6受体和IL-6融合构建的嵌合蛋白，其可用于治疗癌症和肝脏疾病，增强骨髓移植和治疗其他IL-6相关病症。 。
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公开(公告)号：US07198781B1
公开(公告)日：2007-04-03
申请号：US09462416
申请日：1998-07-09
Applicant: Michel Revel , Judith Chebath , Tsvee Lapidot , Orit Kollet
Inventor： Michel Revel , Judith Chebath , Tsvee Lapidot , Orit Kollet
CPC classification number: C12N15/62 , A61K38/00 , C07K14/5412 , C07K14/7155 , C07K2319/00 , C07K2319/02 , C07K2319/32 , C07K2319/71 , C07K2319/95
Abstract: Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.
Abstract translation: 提供由天然存在形式的可溶性IL-6受体和IL-6融合构建的嵌合蛋白，其可用于治疗癌症和肝脏疾病，增强骨髓移植和治疗其他IL-6相关病症。 。
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9.发明申请Stem cells having increased sensitivity to sdf-1 and methods of generating and using same 失效对sdf-1具有增加的敏感性的干细胞及其产生和使用方法公开(公告)号：US20070003540A1
公开(公告)日：2007-01-04
申请号：US10552299
申请日：2004-04-07
Applicant: Orit Kollet , Tsvee Lapidot
Inventor： Orit Kollet , Tsvee Lapidot
CPC classification number: C12N5/0647 , A61K35/16 , A61K35/28 , A61K38/4886 , A61K2035/124 , C12N2501/12 , C12N2501/125 , C12N2501/23 , C12N2501/70
Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.
Abstract translation: 本发明涉及对化学引诱物显示增加的敏感性的干细胞，更具体地涉及产生和使用它们的方法，例如涉及干细胞移植的临床应用。
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10.发明申请公开(公告)号：US20050152871A1
公开(公告)日：2005-07-14
申请号：US10497708
申请日：2002-12-05
Applicant: Orit Kollet
Inventor： Orit Kollet
IPC: C12N15/09 , A61K35/14 , A61K35/28 , A61K35/44 , A61K35/48 , A61K38/00 , A61K38/19 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/16 , A61P3/10 , C07K14/52 , C12N15/19 , A61K31/66 , A61K31/7072
CPC classification number: C07K14/522 , A61K31/513 , A61K31/675 , A61K35/28 , A61K38/00 , A61K38/193 , A61K2300/00
Abstract: The invention relates to transplantation of hematopoietic stem cells (HSC) and/or progenitor cells (HPC) into the liver. More specifically the invention relates to the use of chemokines, preferably SDF-1, for enhancing homing of HSC/HPC to the liver.
Abstract translation: 本发明涉及将造血干细胞（HSC）和/或祖细胞（HPC）移植到肝脏中。 更具体地，本发明涉及趋化因子，优选SDF-1用于增强HSC / HPC归巢到肝脏的用途。
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