-
1.(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS 有权
标题翻译: (HETERO)ARYL CYPOPRAMLAMINE COMPOUNDS AS LSD1 INHIBITORS公开(公告)号:US20150025054A1
公开(公告)日:2015-01-22
申请号:US14352711
申请日:2012-10-22
发明人: Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Maria de los Angeles Estirate Martínez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Lar
IPC分类号: C07D451/04 , C07D405/12 , C07D309/04 , C07D223/12 , C07D205/04 , C07D221/20 , C07D215/42 , C07D401/12 , C07D211/58 , C07D207/14
CPC分类号: C07D211/58 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/96 , C07D211/26 , C07D211/56 , C07D215/42 , C07D221/20 , C07D223/12 , C07D309/04 , C07D309/14 , C07D335/02 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D451/04
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
摘要翻译: 本发明涉及(异)芳基环丙胺化合物,特别包括本文所述和定义的式I化合物及其在治疗中的用途,包括例如治疗或预防癌症,神经疾病或病症,或 病毒感染。
-
公开(公告)号:US20180354902A1
公开(公告)日:2018-12-13
申请号:US15911535
申请日:2018-03-05
发明人: Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Maria de los Angeles Estiarte Martinez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria
IPC分类号: C07D211/58 , C07D335/02 , C07D309/04 , C07D211/56 , C07D211/26 , C07D209/96 , C07D207/14 , C07D207/09 , C07D205/04 , C07D451/04 , C07D417/12 , C07D405/12 , C07D401/12 , C07D401/04 , C07D223/12 , C07D221/20 , C07D215/42 , C07D309/14
CPC分类号: C07D211/58 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/96 , C07D211/26 , C07D211/56 , C07D215/42 , C07D221/20 , C07D223/12 , C07D309/04 , C07D309/14 , C07D335/02 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D451/04
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
-
公开(公告)号:US09670136B2
公开(公告)日:2017-06-06
申请号:US15254020
申请日:2016-09-01
申请人: Oryzon Genomics S.A.
发明人: Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Maria de los Àngeles Estiarte Martinez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria
IPC分类号: A61K31/135 , C07C211/36 , C07D213/74 , C07C271/24 , C07C275/26 , C07D231/12 , C07D207/14 , C07D277/28 , C07D295/096 , C07D295/135 , C07D295/26 , C07D213/30 , C07D213/38 , C07D307/52 , C07C311/08 , C07C311/21 , C07C211/37 , C07C215/46 , C07C217/54 , C07C209/28 , C07C211/38 , C07C269/00 , C07C273/18 , C07C211/40 , C07C213/00 , C07C215/64 , C07C217/74 , C07C273/00 , C07D213/57 , C07D213/73 , C07D231/56 , C07D333/20
CPC分类号: C07C211/36 , C07B2200/07 , C07C209/28 , C07C211/37 , C07C211/38 , C07C211/40 , C07C213/00 , C07C215/46 , C07C215/64 , C07C217/54 , C07C217/74 , C07C269/00 , C07C271/24 , C07C273/00 , C07C273/18 , C07C275/26 , C07C311/08 , C07C311/21 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/14 , C07D213/30 , C07D213/38 , C07D213/57 , C07D213/73 , C07D213/74 , C07D231/12 , C07D231/56 , C07D277/28 , C07D295/096 , C07D295/135 , C07D295/26 , C07D307/52 , C07D333/20
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
-
公开(公告)号:US20180079709A1
公开(公告)日:2018-03-22
申请号:US15497556
申请日:2017-04-26
申请人: Oryzon Genomics S.A.
发明人: Alberto ORTEGA MUÑOZ , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Maria de los Àngeles Estiarte Martinez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria
IPC分类号: C07C211/36 , C07D333/20 , C07C273/00 , C07D213/57 , C07D213/73 , C07D231/56 , C07C213/00 , C07C215/64 , C07C217/74 , C07C211/40 , C07C217/54 , C07C215/46 , C07C311/21 , C07C311/08 , C07C273/18 , C07C209/28 , C07C211/38 , C07C269/00 , C07D213/74 , C07D307/52 , C07D213/38 , C07D213/30 , C07D295/26 , C07D295/135 , C07D295/096 , C07D277/28 , C07D207/14 , C07D231/12 , C07C275/26 , C07C271/24
CPC分类号: C07C211/36 , C07B2200/07 , C07C209/28 , C07C211/37 , C07C211/38 , C07C211/40 , C07C213/00 , C07C215/46 , C07C215/64 , C07C217/54 , C07C217/74 , C07C269/00 , C07C271/24 , C07C273/00 , C07C273/18 , C07C275/26 , C07C311/08 , C07C311/21 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/14 , C07D213/30 , C07D213/38 , C07D213/57 , C07D213/73 , C07D213/74 , C07D231/12 , C07D231/56 , C07D277/28 , C07D295/096 , C07D295/135 , C07D295/26 , C07D307/52 , C07D333/20
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
-
公开(公告)号:US09676701B2
公开(公告)日:2017-06-13
申请号:US14640395
申请日:2015-03-06
发明人: Matthew Colin Thor Fyfe , Alberto Ortega Muñoz , Julio Castro-Palomino Laria , Marc Martinell Pedemonte , Maria de los Angeles Estiarte-Martinez , Nuria Valls Vidal
IPC分类号: C07C211/40 , C07C215/64 , C07C217/64 , C07C217/74 , C07C255/53 , C07C255/54 , C07C311/08 , C07C311/09 , C07C311/21 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/57 , C07D239/26 , C07D277/28 , C07D333/20 , C07D401/04 , C07D405/04 , C07D409/04 , C07C255/59 , C07D213/64 , C07D401/10 , C07D405/10 , C07D409/10
CPC分类号: C07C211/40 , C07B2200/07 , C07C215/64 , C07C217/74 , C07C255/53 , C07C255/54 , C07C255/59 , C07C311/08 , C07C311/09 , C07C311/21 , C07C2601/02 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/57 , C07D213/64 , C07D239/26 , C07D277/28 , C07D333/20 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10
摘要: The invention relates to cyclopropylamine compounds, in particular the compounds of Formula (I), and their use in therapy, including e.g. in the treatment or prevention of cancer, a neurological disease or condition, or viral infection.
-
6.(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS 有权
标题翻译: (HETERO)ARYL CYPOPRAMLAMINE COMPOUNDS AS LSD1 INHIBITORS公开(公告)号:US20140256729A1
公开(公告)日:2014-09-11
申请号:US14352719
申请日:2012-10-22
发明人: Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Maria de los Ángeles Estiarte Martínez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria
IPC分类号: C07C211/36 , C07C209/28 , C07D295/135 , C07D213/38 , C07C275/26 , C07D207/14 , C07C271/24 , C07C273/18 , C07C211/38 , C07C269/00 , C07D277/28
CPC分类号: C07C211/36 , C07B2200/07 , C07C209/28 , C07C211/37 , C07C211/38 , C07C211/40 , C07C213/00 , C07C215/46 , C07C215/64 , C07C217/54 , C07C217/74 , C07C269/00 , C07C271/24 , C07C273/00 , C07C273/18 , C07C275/26 , C07C311/08 , C07C311/21 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/14 , C07D213/30 , C07D213/38 , C07D213/57 , C07D213/73 , C07D213/74 , C07D231/12 , C07D231/56 , C07D277/28 , C07D295/096 , C07D295/135 , C07D295/26 , C07D307/52 , C07D333/20
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and theft use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
摘要翻译: 本发明涉及(异)芳基环丙胺化合物,特别包括本文所述和定义的式(I)化合物和治疗中的盗窃用途,包括例如治疗或预防癌症,神经疾病或病症, 或病毒感染。
-
公开(公告)号:US09944601B2
公开(公告)日:2018-04-17
申请号:US15271772
申请日:2016-09-21
发明人: Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Maria de los Àngeles Estiarte Martinez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria
IPC分类号: C07D211/58 , C07D309/04 , C07D309/14 , C07D215/42 , C07D221/20 , C07D223/12 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D451/04 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/96 , C07D211/26 , C07D211/56 , C07D335/02
CPC分类号: C07D211/58 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/96 , C07D211/26 , C07D211/56 , C07D215/42 , C07D221/20 , C07D223/12 , C07D309/04 , C07D309/14 , C07D335/02 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D451/04
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
-
公开(公告)号:US09487512B2
公开(公告)日:2016-11-08
申请号:US14352711
申请日:2012-10-22
发明人: Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Maria de los Angeles Estiarte Martinez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria
IPC分类号: C07D451/04 , C07D309/04 , C07D309/14 , C07D215/42 , C07D221/20 , C07D223/12 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/96 , C07D211/26 , C07D211/56 , C07D211/58
CPC分类号: C07D211/58 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/96 , C07D211/26 , C07D211/56 , C07D215/42 , C07D221/20 , C07D223/12 , C07D309/04 , C07D309/14 , C07D335/02 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D451/04
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
摘要翻译: 本发明涉及(异)芳基环丙胺化合物,特别包括本文所述和定义的式I化合物及其在治疗中的用途,包括例如治疗或预防癌症,神经疾病或病症,或 病毒感染。
-
公开(公告)号:US09469597B2
公开(公告)日:2016-10-18
申请号:US14352719
申请日:2012-10-22
发明人: Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , María de los Ángeles Estiarte Martínez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria
IPC分类号: C07C211/36 , C07C209/28 , C07D295/135 , C07D213/38 , C07C275/26 , C07D207/14 , C07C271/24 , C07C273/18 , C07C211/38 , C07C269/00 , C07D277/28 , C07D213/74 , C07D231/12 , C07D295/096 , C07D295/26 , C07D213/30 , C07D307/52 , C07C311/08 , C07C311/21 , C07C211/37 , C07C215/46 , C07C217/54
CPC分类号: C07C211/36 , C07B2200/07 , C07C209/28 , C07C211/37 , C07C211/38 , C07C211/40 , C07C213/00 , C07C215/46 , C07C215/64 , C07C217/54 , C07C217/74 , C07C269/00 , C07C271/24 , C07C273/00 , C07C273/18 , C07C275/26 , C07C311/08 , C07C311/21 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/14 , C07D213/30 , C07D213/38 , C07D213/57 , C07D213/73 , C07D213/74 , C07D231/12 , C07D231/56 , C07D277/28 , C07D295/096 , C07D295/135 , C07D295/26 , C07D307/52 , C07D333/20
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and theft use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
摘要翻译: 本发明涉及(异)芳基环丙胺化合物,特别包括本文所述和定义的式(I)化合物和治疗中的盗窃用途,包括例如治疗或预防癌症,神经疾病或病症, 或病毒感染。
-
公开(公告)号:US10329256B2
公开(公告)日:2019-06-25
申请号:US15911535
申请日:2018-03-05
发明人: Alberto Ortega Muñoz , Matthew Colin Thor Fyfe , Marc Martinell Pedemonte , Maria de los Àngeles Estiarte Martinez , Nuria Valls Vidal , Guido Kurz , Julio Cesar Castro Palomino Laria
IPC分类号: C07D211/58 , C07D309/04 , C07D309/14 , C07D215/42 , C07D221/20 , C07D223/12 , C07D401/04 , C07D401/12 , C07D405/12 , C07D417/12 , C07D451/04 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/96 , C07D211/26 , C07D211/56 , C07D335/02
摘要: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
-
-
-
-
-
-
-
-
-