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    IMAGE DIFFERENTIATED MULTIPLEX ASSAYS FOR DETECTION OF DNA MUTATIONS IN LUNG CANCER
    2.
    发明申请
    IMAGE DIFFERENTIATED MULTIPLEX ASSAYS FOR DETECTION OF DNA MUTATIONS IN LUNG CANCER 有权

    公开(公告)号：US20230052147A1

    公开(公告)日：2023-02-16

    申请号：US17758511

    申请日：2021-01-07

    申请人： PLEXBIO CO., LTD.

    发明人： Dean TSAO ,  Chin-Shiou HUANG ,  Shian Pin HU ,  Fei-Yu CHANG ,  Yi Ling HSIEH

    IPC分类号： C12Q1/6827 ,  C12Q1/6886 ,  C12Q1/6834

    摘要： Provided herein are methods and kits for detecting the presence of DNA and/or RNA mutations associated with cancer (e.g., lung cancer). The methods and kits employ microcarriers, each with a probe specific for a DNA or RNA mutation and an identifier unique to the probe sequence. Upon isolation and amplification of nucleic acids from a sample, hybridization of amplified DNA with a probe, specific for a DNA or RNA mutation, that is coupled to a microcarrier indicates the presence of the mutation in the sample. Since each microcarrier can be identified through detection of the identifier, multiplex screening assays are provided. Representative genes that can be screened for mutations include, e.g., KRAS, NRAS, PIK3CA, BRAF, EGFR, AKT1, MEK1, and HER2 for DNA mutations and/or ALK, ROS, RET, NTRK1, and cMET for RNA mutations.

    IMAGE DIFFERENTIATED MULTIPLEX ASSAYS
    4.
    发明申请
    IMAGE DIFFERENTIATED MULTIPLEX ASSAYS 审中-公开

    公开(公告)号：US20190265567A1

    公开(公告)日：2019-08-29

    申请号：US16386092

    申请日：2019-04-16

    申请人： Plexbio Co., Ltd.

    发明人： Dean TSAO ,  Chin-Shiou HUANG ,  Yao-Kuang CHUNG

    IPC分类号： G02F1/1362 ,  G09G3/36 ,  H01L27/12

    摘要： Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.

    METHODS AND SYSTEMS FOR MULTIPLEX ASSAYS
    7.
    发明申请
    METHODS AND SYSTEMS FOR MULTIPLEX ASSAYS 审中-公开
    多重测定的方法和系统

    公开(公告)号：US20140274778A1

    公开(公告)日：2014-09-18

    申请号：US14208481

    申请日：2014-03-13

    申请人： PLEXBIO CO., LTD.

    发明人： Dean TSAO ,  Chin-Shiou HUANG

    IPC分类号： G01N33/58

    CPC分类号： G01N33/54313 ,  C40B30/04 ,  C40B40/04 ,  C40B50/16

    摘要： Disclosed herein are compositions comprising beads with unique identifiers for storing information about a multiplex assay as well as methods for using the same in multiplex chemical and biological assays.

    摘要翻译： 本文公开了包含具有用于存储关于多重测定的信息的唯一标识符的珠的组合物以及在多重化学和生物测定中使用该多核测定的方法。