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公开(公告)号：US08535650B2
公开(公告)日：2013-09-17
申请号：US10497775
申请日：2002-12-03
IPC分类号： A61K9/107 , A61K31/727
CPC分类号： A61K31/727 , A61K8/0291 , A61K9/107 , A61K9/1075 , A61K9/4891 , A61K38/09 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61Q19/00
摘要： The invention relates to compositions and methods for drug delivery suitable for promoting the transmucosal absorption of drugs, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and other polar solvents to form reverse micelles that are physically stabilized in the presence of gastrointestinal fluid, water, and other hydrophilic solvents. Such stable reverse micelles are formed by suitable mixtures of polymeric or non-polymeric compounds with amphiphiles. Micelles made using these methods undergo phase transformation more slowly resulting in delayed drug release profiles and sustained absorption. When administered as a pharmaceutical to mucosal surfaces following oral ingestion or intranasal administration, therapeutic molecules principally solubilized in the aqueous phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions may comprise mono-, di-glycerides and/or their transesterified products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrophilic moieties.
摘要翻译： 本发明涉及用于药物递送的组合物和方法，其适用于促进药物，特别是具有差的内在生物利用度的药物（例如肽，蛋白质，疫苗和核酸）的经粘膜吸收。 本发明的递送系统优选包括与水和其它极性溶剂缔合的脂肪酸酯及其亲水性衍生物，以形成在胃肠液，水和其它亲水溶剂存在下物理稳定的反胶束。 这种稳定的反胶束由聚合物或非聚合物与两亲物的合适混合物形成。 使用这些方法制备的胶束进行相变更慢，导致延迟的药物释放曲线和持续吸收。 当口服摄取或鼻内给药后作为药物施用于粘膜表面时，主要溶解在水相中的治疗分子被保护不被粘膜酶和其它粘膜降解过程消化，并被吸收细胞机制吸收并达到适当的身体隔室。 反胶束组合物可以包含含有C 6 -C 12脂肪酸链的单 - ，二 - 甘油酯和/或其酯交换产物，其中所述酯基组由亲水部分组成。
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公开(公告)号：US20050079145A1
公开(公告)日：2005-04-14
申请号：US10497775
申请日：2002-12-03
IPC分类号： A61K8/14 , A61K9/107 , A61K9/48 , A61K31/727 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/34 , A61K47/48 , A61Q19/00 , A61K7/06 , A61K7/075 , A61K7/08 , A61K7/11
CPC分类号： A61K31/727 , A61K8/0291 , A61K9/107 , A61K9/1075 , A61K9/4891 , A61K38/09 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61Q19/00
摘要： The invention relates to compositions and methods for drug delivery suitable for promoting the transmucosal absorption of drugs, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and other polar solvents to form reverse micelles tha are physically stabilized in the presence of gastrointestinal fluid, water, and other hydrophilic solvents. Such stable reverse micelles are formed by suitable mixtures of polymeric or non-polymeric compounds with amphiphiles. Micelles made using these methods undergo phase transformation more slowly resulting in delayed drug release profiles and sustained absorption. When administered as a pharmaceutical to mucosal surfaces following oral ingestion or intranasal administration, therapeutic molecules principally solubilized in the aqueous phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions may comprise mono-, di-glycerides and/or their transesterifed products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrohilic moieties.
摘要翻译： 本发明涉及用于药物递送的组合物和方法，其适用于促进药物，特别是具有差的内在生物利用度的药物（例如肽，蛋白质，疫苗和核酸）的经粘膜吸收。 本发明的递送系统优选包含与水和其它极性溶剂缔合以形成反胶束的脂肪酸酯及其亲水性衍生物，其在胃肠液，水和其它亲水溶剂存在下物理稳定。 这种稳定的反胶束由聚合物或非聚合物与两亲物的合适混合物形成。 使用这些方法制备的胶束进行相变更慢，导致延迟的药物释放曲线和持续吸收。 当口服摄取或鼻内给药后作为药物施用于粘膜表面时，主要溶解在水相中的治疗分子被保护不被粘膜酶和其它粘膜降解过程消化，并被吸收细胞机制吸收并达到适当的身体隔室。 反胶束组合物可以包含含有C6-C12脂肪酸链的单 - ，二 - 甘油酯和/或其酯交换产物，其中酯基组由亲水部分组成。
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公开(公告)号：US20070020307A1
公开(公告)日：2007-01-25
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。 辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。
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公开(公告)号：US20070160641A1
公开(公告)日：2007-07-12
申请号：US11332606
申请日：2006-01-12
申请人： Eun-Hyun Jang
发明人： Eun-Hyun Jang
IPC分类号： A61F2/02 , A61K31/517 , A61K31/337
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/60 , A61L2300/606 , A61L2300/61
摘要： The present invention relates generally to coated medical devices, preferably a stent, that has a drug-eluting surface completely or partially coated with a coating that comprises two or more forms of a biologically active material. In particular, the invention is directed to a coated medical device having a coating that comprises at least one polymer and a biologically active material that is present in at least two different forms. The coating may include more than one coating layer. Preferably, the coating is capable of releasing the different forms of the biologically active material in different amounts, at different rates, and/or at different time periods. The invention also relates to methods of making and methods of using the coated medical device.
摘要翻译： 本发明一般涉及具有完全或部分涂覆有包含两种或多种形式的生物活性材料的涂层的药物洗脱表面的涂覆医疗装置，优选支架。 特别地，本发明涉及具有包含至少两种不同形式的至少一种聚合物和生物活性材料的涂层的涂覆医疗装置。 涂层可以包括多于一个的涂层。 优选地，涂层能够以不同的速率和/或在不同的时间段以不同的量释放不同形式的生物活性材料。 本发明还涉及制造方法和使用涂覆的医疗装置的方法。
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公开(公告)号：US08722074B2
公开(公告)日：2014-05-13
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
IPC分类号： A61F2/02
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。 辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。
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公开(公告)号：US20070160640A1
公开(公告)日：2007-07-12
申请号：US11330448
申请日：2006-01-12
申请人： Eun-Hyun Jang , Young-Ho Song , Robert Herrmann , Anurag Singhal , Brad Pires , Andrew Saati
发明人： Eun-Hyun Jang , Young-Ho Song , Robert Herrmann , Anurag Singhal , Brad Pires , Andrew Saati
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416
摘要： A medical device comprising halofuginone is provided. The medical device is adapted for implantation or insertion into a blood vessel and it provides a cumulative, in vivo, 14 day release that lies between 0.02 μg and 0.2 μg of halofuginone per mm2 of stent surface area.
摘要翻译： 提供了包含卤夫酮的医疗装置。 该医疗装置适于植入或插入血管，并且其提供累积的体内14天释放，其位于每平方米支架表面积的0.02微克和0.2杯卤伏酮之间。
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公开(公告)号：US20070196451A1
公开(公告)日：2007-08-23
申请号：US11358117
申请日：2006-02-22
申请人： Anurag Singhal , Robert Herrmann , Eun-Hyun Jang , Young-Ho Song
发明人： Anurag Singhal , Robert Herrmann , Eun-Hyun Jang , Young-Ho Song
CPC分类号： A61M25/0082 , A61M25/0074 , A61M31/00
摘要： The present invention relates to a device and method for delivery of a patch, graft, implant, therapeutic agent, or other device onto tissue using a rolled delivery mechanism. In one embodiment, a rolled delivery mechanism is provided for delivering a patch to tissue when the rolled delivery mechanism is unrolled. In another embodiment, a rolled delivery mechanism is provided for delivering therapeutic agent to a target tissue.
摘要翻译： 本发明涉及一种用于使用轧制递送机构将补片，移植物，植入物，治疗剂或其它装置递送到组织上的装置和方法。 在一个实施例中，提供了一种轧制递送机构，用于在轧制的递送机构展开时将补片递送到组织。 在另一个实施方案中，提供了用于将治疗剂递送至靶组织的卷绕递送机构。
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