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91 条记录 (耗时 0.033 秒)

    Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation
    7.
    发明授权
    Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation 失效
    取代（芳基烷氧基苄基）氨基丙酰胺衍生物及其制备方法

    公开(公告)号：US5446066A

    公开(公告)日：1995-08-29

    申请号：US215628

    申请日：1994-03-22

    申请人： Mario Varasi ,  Philippe Dostert ,  Paolo Pevarello ,  Alberto Bonsignori

    发明人： Mario Varasi ,  Philippe Dostert ,  Paolo Pevarello ,  Alberto Bonsignori

    IPC分类号： A61K31/165 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07C231/10 ,  C07C237/00 ,  C07C237/06 ,  C07C233/04

    CPC分类号： C07C237/00

    摘要： The invention provides new compounds of formula (I) ##STR1## wherein, subject to a proviso, n is zero or an integer of 1 to 3; each of R and R.sub.1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy; R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl optionally substituted by hydroxy; each of R.sub.3 and R.sub.4 independently is hydrogen or C.sub.1 -C.sub.4 alkyl; or a pharmaceutically acceptable salt thereof; and of formula (IA) ##STR2## wherein R.sub.5 is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy, or a pharmaceutically acceptable salt thereof, which are active on the central nervous system (CNS) and can be used in therapy as anti-epileptics, anti-Parkinson, neuroprotective, antidepressant, anti-spastic and hypnotic agents.

    摘要翻译： 本发明提供新的式（I）化合物其中，条件是n为0或1〜3的整数; R和R 1可以相同或不同，为氢，卤素，三氟甲基或C 1 -C 4烷氧基; R2是氢或任选被羟基取代的C 1 -C 4烷基; R 3和R 4各自独立地是氢或C 1 -C 4烷基; 或其药学上可接受的盐; 和式（IA）的化合物（IA）其中R5是氢，卤素，三氟甲基或C1-C4烷氧基，或其药学上可接受的盐，其在中枢神经系统（CNS）上是有活性的并且可以用于治疗 作为抗癫痫药，抗帕金森综合征，神经保护药，抗抑郁药，抗痉挛药和催眠药。

    Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
    10.
    发明授权
    Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation 失效
    取代的（芳基烷基氨基苄基）氨基丙酰胺衍生物及其制备方法

    公开(公告)号：US5449692A

    公开(公告)日：1995-09-12

    申请号：US215694

    申请日：1994-03-22

    申请人： Mario Varasi ,  Philippe Dostert ,  Paolo Pevarello ,  Alberto Bonsignori

    发明人： Mario Varasi ,  Philippe Dostert ,  Paolo Pevarello ,  Alberto Bonsignori

    IPC分类号： A61K31/165 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07C231/10 ,  C07C237/06 ,  C07C233/05

    CPC分类号： C07C237/06

    摘要： The invention provides new compounds of formula (I) ##STR1## wherein n is an integer of 1 to 4; each of R and R.sub.1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.4 alkoxy; R2 is hydrogen or C.sub.1 -C.sub.4 alkyl; and a pharmaceutically acceptable salts thereof; and wherein when, at the same time, R is hydrogen, R.sub.1 is hydrogen or halogen and n is one, then R.sub.2 is other than hydrogen or methyl; and of formula (IA) ##STR2## wherein R.sub.3 is halogen, and a pharmaceutical acceptable salt thereof, which are active on the central nervous system (CNS) and can be used in therapy as anti-epileptics, anti-Parkinson, neuroprotective, antidepressant, anti-spastic and hypnotic agents.

    摘要翻译： 本发明提供新的式（I）化合物其中n为1至4的整数; R和R 1可以相同或不同，为氢，卤素，三氟甲基或C 1 -C 4烷氧基; R2是氢或C1-C4烷基; 及其药学上可接受的盐; 并且其中当R同时为氢时，R 1为氢或卤素且n为1，则R 2为氢或甲基; 和式（IA）其中R 3是卤素的式（IA）及其药学上可接受的盐，其在中枢神经系统（CNS）上是有活性的，可用于治疗作为抗癫痫药，抗帕金森病， 神经保护，抗抑郁药，抗痉挛药和催眠药。