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1.发明申请Compositions Comprising Addl Receptors, Related Compositions, and Related Methods 审中-公开包含Addl受体，相关组合物和相关方法的组合物公开(公告)号：US20080306074A1
公开(公告)日：2008-12-11
申请号：US11569122
申请日：2005-05-16
申请人： Pascale N. Lacor , Kirsten L. Viola , Mary P. Lambert , Yeusong Gong , Lei Chang , Pauline T. Velasco , Eileen H. Bigio , Maria C. Buniel , Sara J. Fernandez , Jasna Jerecic , Susan Catalano , Todd Pray , Ray Lowe , Grant A. Krafft , William L. Klein
发明人： Pascale N. Lacor , Kirsten L. Viola , Mary P. Lambert , Yeusong Gong , Lei Chang , Pauline T. Velasco , Eileen H. Bigio , Maria C. Buniel , Sara J. Fernandez , Jasna Jerecic , Susan Catalano , Todd Pray , Ray Lowe , Grant A. Krafft , William L. Klein
IPC分类号： A61K31/498 , G01N33/567 , A61P25/28
CPC分类号： C07K14/4711 , A61K31/495 , A61K38/00 , G01N33/5058 , G01N2800/2821
摘要： Disclosed and claimed herein are compositions comprising ADDL receptors, related compositions, and related methods. ADDL receptors are typically, but perhaps not exclusively, localized at the post-synaptic density (PSD) of neuronal cells. Related compositions include, but are not limited to, compounds that affect, positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise. Related methods include, but are not limited to, procedures to screen for compounds that affect, either positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise. Other related methods include, but are not limited to, prevention and treatment of ADDL-related diseases, such as Alzheimer's disease, mild cognitive impairment, Down's syndrome, and the like, using compositions that inhibit, block, or otherwise interfere with ADDL binding to one or more receptors localized at the post-synaptic density of neuronal cells.
摘要翻译： 本文公开和要求保护的是包含ADDL受体，相关组合物和相关方法的组合物。 ADDL受体通常但不限于，定位于神经元细胞的突触后密度（PSD）。 相关的组合物包括但不限于通过局限在突触后的密度（PSD）或其他方式的一种或多种受体影响ADDL与神经元细胞结合的积极或消极的化合物。 相关方法包括但不限于筛选通过一种或多种局限在突触后密度（PSD）或其他方式的受体而影响ADDL与神经元细胞结合的化合物的方法。 其他相关方法包括但不限于使用抑制，阻断或以其他方式干扰ADDL结合的组合物预防和治疗ADDL相关疾病，例如阿尔茨海默氏病，轻度认知障碍，唐氏综合征等。 位于神经元细胞突触后密度的一个或多个受体。
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公开(公告)号：US20150011002A1
公开(公告)日：2015-01-08
申请号：US14324636
申请日：2014-07-07
申请人： Ankush Argade , Rajinder Singh , Hui Li , David Carroll , Susan Catalano
发明人： Ankush Argade , Rajinder Singh , Hui Li , David Carroll , Susan Catalano
IPC分类号： C07D498/04 , C07D413/12 , C07D401/12 , C07D417/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D405/12 , C07D239/48 , C07D401/14
CPC分类号： C07D498/04 , A61K31/4353 , A61K31/505 , A61K31/506 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
摘要翻译： 本发明提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US08809341B2
公开(公告)日：2014-08-19
申请号：US12981094
申请日：2010-12-29
申请人： Ankush Argade , Rajinder Singh , Hui Li , David Carroll , Susan Catalano
发明人： Ankush Argade , Rajinder Singh , Hui Li , David Carroll , Susan Catalano
IPC分类号： A61K31/505 , A61K31/535 , A61K31/497 , C07D239/42
CPC分类号： C07D498/04 , A61K31/4353 , A61K31/505 , A61K31/506 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
摘要翻译： 本发明提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US20120129945A1
公开(公告)日：2012-05-24
申请号：US13388128
申请日：2010-08-02
申请人： Gilbert M. Rishton , Susan Catalano
发明人： Gilbert M. Rishton , Susan Catalano
IPC分类号： A61K31/137 , C07C33/30 , A61K31/045 , A61P25/28 , C07C211/25 , C07C209/22 , C07C29/143 , A61K31/13 , C07C211/27 , C07C33/14
CPC分类号： C07C211/27 , A61K31/015 , C07B2200/07 , C07C33/14 , C07C33/30 , C07C211/25 , C07C403/08 , C07C403/18 , C07C2601/16
摘要： Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
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公开(公告)号：US07884111B2
公开(公告)日：2011-02-08
申请号：US11567820
申请日：2006-12-07
申请人： Ankush Argade , Rajinder Singh , Hui Li , David Carroll , Susan Catalano
发明人： Ankush Argade , Rajinder Singh , Hui Li , David Carroll , Susan Catalano
IPC分类号： A61K31/505 , C07D239/42 , A01N43/00
CPC分类号： C07D498/04 , A61K31/4353 , A61K31/505 , A61K31/506 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
摘要翻译： 本发明提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US08765816B2
公开(公告)日：2014-07-01
申请号：US13263162
申请日：2010-04-06
申请人： Gilbert M. Rishton , Susan Catalano
发明人： Gilbert M. Rishton , Susan Catalano
CPC分类号： C07C217/62 , C07C211/27 , C07D207/08 , C07D211/22
摘要： Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
摘要翻译： 提供了用于治疗认知衰退的中枢神经系统药物候选物的化合物，更具体地说是阿尔茨海默氏病。 还提供了用本发明的化合物或药学上可接受的盐治疗，抑制和/或减轻认知衰退和/或阿尔茨海默病的方法。 还提供了制备本发明的化合物/组合物的方法。
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7.发明申请METHODS OF IDENTIFYING AGENTS EFFECTIVE TO TREAT COGNITIVE DECLINE AND DISEASES ASSOCIATED THEREWITH 审中-公开鉴别有效治疗与其相关的认知失调和疾病的药物的方法公开(公告)号：US20130071330A1
公开(公告)日：2013-03-21
申请号：US13581144
申请日：2011-02-28
申请人： Susan Catalano
发明人： Susan Catalano
CPC分类号： C12Q1/025 , A61K49/00 , G01N33/5035 , G01N33/5058 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Embodiments described herein are directed to methods of identifying agents effective to treat cognitive decline and diseases associated therewith. Embodiments described herein are also directed to kits for performing methods described herein. Embodiments described are also directed to methods of diagnosis and uses of the same.
摘要翻译： 本文描述的实施方案涉及鉴定有效治疗认知衰退和与之相关疾病的药剂的方法。 本文描述的实施例还涉及用于执行本文所述的方法的套件。 所描述的实施例还涉及诊断方法及其用途。
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公开(公告)号：US20120059595A1
公开(公告)日：2012-03-08
申请号：US13219506
申请日：2011-08-26
申请人： Susan Catalano , John McLaughlin
发明人： Susan Catalano , John McLaughlin
IPC分类号： G06F19/00
CPC分类号： G01N33/5011 , C12Q1/6841 , G01N33/502 , G01N33/582
摘要： The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell proliferation, cell cycling and cell death. The multiparameter assay is particularly useful for assessing and screening candidate compounds for anti-cancer utility.
摘要翻译： 本发明提供了一种用于分析细胞样本的装置，系统，方法和计算机程序和计算机程序产品。 该装置和方法的一个实施方案提供了多参数测定，其提供关于细胞增殖，细胞循环和细胞死亡的信息。 多参数测定特别可用于评估和筛选候选化合物用于抗癌效用。
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公开(公告)号：US08032346B1
公开(公告)日：2011-10-04
申请号：US11726396
申请日：2007-03-20
申请人： Susan Catalano , John McLaughlin
发明人： Susan Catalano , John McLaughlin
CPC分类号： G01N33/5011 , C12Q1/6841 , G01N33/502 , G01N33/582
摘要： The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell proliferation, cell cycling and cell death. The multiparameter assay is particularly useful for assessing and screening candidate compounds for anti-cancer utility.
摘要翻译： 本发明提供了一种用于分析细胞样本的装置，系统，方法和计算机程序和计算机程序产品。 该装置和方法的一个实施方案提供了多参数测定，其提供关于细胞增殖，细胞循环和细胞死亡的信息。 多参数测定特别可用于评估和筛选候选化合物用于抗癌效用。
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10.发明申请公开(公告)号：US20110190271A1
公开(公告)日：2011-08-04
申请号：US12981094
申请日：2010-12-29
申请人： Ankush Argade , Rajinder Singh , Hui Li , David Carroll , Susan Catalano
发明人： Ankush Argade , Rajinder Singh , Hui Li , David Carroll , Susan Catalano
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/538 , A61K31/5415 , A61K31/5383 , A61P35/00
CPC分类号： C07D498/04 , A61K31/4353 , A61K31/505 , A61K31/506 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
摘要翻译： 本发明提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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