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    Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
    2.
    发明授权
    Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation 有权
    核酸与二硫键交联阳离子组分的复合用于转染和免疫刺激

    公开(公告)号：US08968746B2

    公开(公告)日：2015-03-03

    申请号：US13203653

    申请日：2011-07-25

    申请人： Patrick Baumhof ,  Söhnke Voss ,  Thomas Kramps ,  Karl-Josef Kallen

    发明人： Patrick Baumhof ,  Söhnke Voss ,  Thomas Kramps ,  Karl-Josef Kallen

    IPC分类号： A61K39/385 ,  A61K45/00 ,  A61K47/00 ,  A61K48/00 ,  A61K39/39 ,  C12N15/87 ,  A61K39/00

    CPC分类号： A61K48/0041 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61K47/645 ,  A61K2039/51 ,  A61K2039/55516 ,  A61K2039/55561 ,  C12N15/87 ,  Y02A50/412 ,  Y02A50/472

    摘要： The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid (molecule) and disulfide-crosslinked cationic components as a (preferably non-toxic and non-immunogenic) polymeric carrier. The inventive polymeric carrier cargo complex allows for both efficient transfection of nucleic acids into cells in vivo and in vitro and/or for induction of an (innate and/or adaptive) immune response, preferably dependent on the nucleic acid to be transported as a cargo. The present invention also provides, pharmaceutical compositions, particularly vaccines and adjuvants, comprising the inventive polymeric carrier cargo complex and optionally an antigen, as well as the use of such the inventive polymeric carrier cargo complex and optionally an antigen for transfecting a cell, a tissue or an organism, for (gene-)therapeutic purposes as disclosed herein, and/or as an immunostimulating agent or adjuvant, e.g. for eliciting an immune response for the treatment or prophylaxis of diseases as mentioned above. Finally, the invention relates to kits containing the inventive polymeric carrier cargo complex and/or the inventive pharmaceutical composition, adjuvant or vaccine in one or more parts of the kit.

    摘要翻译： 本发明涉及一种聚合物载体货物复合物，其包含至少一种核酸（分子）和作为（优选无毒的和非免疫原性的）聚合物载体的二硫键交联的阳离子组分。 本发明的聚合物载体货物复合物允许在体内和体外有效地将核酸转染到细胞中和/或诱导（先天和/或自适应）免疫应答，优选依赖于作为货物运输的核酸 。 本发明还提供药物组合物，特别是疫苗和佐剂，其包含本发明的聚合物载体货物复合物和任选的抗原，以及使用本发明的本发明的聚合物载体货物复合物和任选的抗原用于转染细胞，组织 或用于本文公开的（基因 - ）治疗目的的生物体，和/或作为免疫刺激剂或佐剂，例如， 用于引发用于治疗或预防上述疾病的免疫应答。 最后，本发明涉及在试剂盒的一个或多个部分中含有本发明的聚合物载体货物复合物和/或本发明的药物组合物，佐剂或疫苗的试剂盒。

    Nucleic acids comprising formula (NuGlXmGnNv)a and derivatives thereof as immunostimulating agent/adjuvant
    6.
    发明授权
    Nucleic acids comprising formula (NuGlXmGnNv)a and derivatives thereof as immunostimulating agent/adjuvant 有权
    包含式（NuG1XmGnNv）a及其衍生物的核酸作为免疫刺激剂/佐剂

    公开(公告)号：US09226959B2

    公开(公告)日：2016-01-05

    申请号：US12672442

    申请日：2009-01-28

    申请人： Thomas Kramps ,  Söhnke Voss ,  Jochen Probst ,  Ingmar Hoerr

    发明人： Thomas Kramps ,  Söhnke Voss ,  Jochen Probst ,  Ingmar Hoerr

    IPC分类号： C07H21/02 ,  A61K39/00 ,  A61K39/39 ,  A61P37/04 ,  C07H21/00 ,  C12N15/117

    CPC分类号： A61K39/39 ,  A61K2039/53 ,  A61K2039/55561 ,  A61K2039/572 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2320/31 ,  Y02A50/491

    摘要： The present invention relates to nucleic acids of the general formula (I): (NuGlXmGnNv)a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to the use of the pharmaceutical composition or of the vaccine for the treatment of cancer diseases, infectious diseases, allergies and autoimmune diseases etc. Likewise, the present invention includes the use of nucleic acids of the general formula (I): (NuGlXmGnNv)a and/or derivatives thereof for the preparation of a pharmaceutical composition for the treatment of such diseases.

    摘要翻译： 本发明涉及通式（I）的核酸：（NuG1XmGnNv）a及其衍生物作为免疫刺激剂/佐剂和含有其的组合物，任选地包含另外的佐剂。 本发明还涉及药物组合物或疫苗，其各自含有上述式（I）核酸和/或其衍生物作为免疫刺激剂，以及任选的至少一种另外的药物活性成分，例如， 抗原剂。 本发明同样涉及药物组合物或疫苗用于治疗癌症疾病，感染性疾病，过敏症和自身免疫疾病等的用途。同样地，本发明包括通式（I）的核酸， ：（NuGlXmGnNv）a和/或其衍生物，用于制备用于治疗这些疾病的药物组合物。

    Nucleic Acids Comprising formula (NuGlXmGnNv)a and Derivatives Thereof as Immunostimulating Agent/Adjuvant
    7.
    发明申请
    Nucleic Acids Comprising formula (NuGlXmGnNv)a and Derivatives Thereof as Immunostimulating Agent/Adjuvant 有权
    核酸包含式（NuGlXmGnNv）a及其衍生物作为免疫刺激剂/佐剂

    公开(公告)号：US20120021043A1

    公开(公告)日：2012-01-26

    申请号：US12672442

    申请日：2009-01-28

    申请人： Thomas Kramps ,  Sohnke Voss ,  Jochen Probst ,  Ingmar Hoerr

    发明人： Thomas Kramps ,  Sohnke Voss ,  Jochen Probst ,  Ingmar Hoerr

    IPC分类号： A61K39/39 ,  A61K9/127 ,  A61K38/20 ,  A61P37/04 ,  A61K9/14 ,  A61K39/395 ,  A61K39/00 ,  A61P35/00 ,  C07H21/02 ,  A61K38/21

    CPC分类号： A61K39/39 ,  A61K2039/53 ,  A61K2039/55561 ,  A61K2039/572 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2320/31 ,  Y02A50/491

    摘要： The present invention relates to nucleic acids of the general formula (I): (NuGlXmGnNv)a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to the use of the pharmaceutical composition or of the vaccine for the treatment of cancer diseases, infectious diseases, allergies and autoimmune diseases etc. Likewise, the present invention includes the use of nucleic acids of the general formula (I): (NuGlXmGnNv)a and/or derivatives thereof for the preparation of a pharmaceutical composition for the treatment of such diseases.

    摘要翻译： 本发明涉及通式（I）的核酸：（NuG1XmGnNv）a及其衍生物作为免疫刺激剂/佐剂和含有其的组合物，任选地包含另外的佐剂。 本发明还涉及药物组合物或疫苗，其各自含有上述式（I）核酸和/或其衍生物作为免疫刺激剂，以及任选的至少一种另外的药物活性成分，例如， 抗原剂。 本发明同样涉及药物组合物或疫苗用于治疗癌症疾病，感染性疾病，过敏症和自身免疫疾病等的用途。同样地，本发明包括通式（I）的核酸， ：（NuGlXmGnNv）a和/或其衍生物，用于制备用于治疗这些疾病的药物组合物。

    Essential downstream component of the wingless signaling pathway and therapeutic and diagnostic applications based thereon
    9.
    发明授权
    Essential downstream component of the wingless signaling pathway and therapeutic and diagnostic applications based thereon 失效
    基于其的无翼信号传导途径的基本下游部分和治疗和诊断应用

    公开(公告)号：US07252951B2

    公开(公告)日：2007-08-07

    申请号：US10322579

    申请日：2002-12-19

    申请人： Konrad Basler ,  Erich Brunner ,  Barbara Froesch ,  Thomas Kramps ,  Oliver Peter

    发明人： Konrad Basler ,  Erich Brunner ,  Barbara Froesch ,  Thomas Kramps ,  Oliver Peter

    IPC分类号： G01N33/53 ,  G01N33/543

    CPC分类号： C12N15/113 ,  C07K14/43581 ,  C07K14/4702 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates to nucleotide sequences of the Drosophila melanogaster legless (lgs) gene, of its encoded proteins, as well as derivatives (e.g., fragments) and analogues thereof. The invention further includes vertebrate and invertebrate homologues of the Lgs protein, comprising proteins that contain a contiguous stretch of amino acids with similarity to the Drosophila lgs gene. The invention further relates to the function of the Drosophila and the human Lgs proteins. Methods for producing the Lgs proteins, derivatives and analogs, e.g., by recombinant means and antibodies to Lgs are provided by the present invention. In addition, the invention also relates to the therapeutic and diagnostic methods and compositions based on Lgs proteins and nucleic acids or fragments thereof.

    摘要翻译： 本发明涉及Wnt / Wingless（Wnt / Wg）信号传导途径的新的基本下游组分以及其上的治疗和诊断应用。 本发明涉及黑腹果蝇无基因（lgs）基因，其编码的蛋白质以及衍生物（例如片段）及其类似物的核苷酸序列。 本发明还包括Lgs蛋白质的脊椎动物和无脊椎动物同系物，其包含与果蝇lgs基因具有相似性的氨基酸的连续片段的蛋白质。 本发明还涉及果蝇和人Lgs蛋白的功能。 通过本发明提供了通过重组方法和Lgs的抗体产生Lgs蛋白质，衍生物和类似物的方法。 此外，本发明还涉及基于Lgs蛋白质和核酸或其片段的治疗和诊断方法和组合物。