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1.发明授权Hybrid cell line for producing monoclonal antibody to a human monocyte antigen, antibody, and methods 失效用于产生人单核细胞抗原的单克隆抗体的杂交细胞系，抗体和方法
公开(公告)号：US5196310A
公开(公告)日：1993-03-23
申请号：US389246
申请日：1989-08-03
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于在正常人单核细胞和粒细胞上发现的抗原的单克隆抗体的杂交细胞系。 通过将来自免疫的BALB / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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2.发明授权Compositions and methods using a monoclonal antibody to a human T cell antigen 失效使用单克隆抗体对人T细胞抗原的组合物和方法
公开(公告)号：US4798806A
公开(公告)日：1989-01-17
申请号：US892019
申请日：1986-08-01
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , G01N33/569 , G01N33/54
CPC分类号： C07K16/2806 , G01N33/56972 , A61K38/00
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于在基本上所有正常人T细胞和大约95％正常人胸腺细胞上发现的抗原的单克隆抗体的杂交细胞系。 通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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公开(公告)号：US4680383A
公开(公告)日：1987-07-14
申请号：US639563
申请日：1984-08-10
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , C07K16/30 , G01N33/569 , C07K15/00 , A61K39/395
CPC分类号： G01N33/56972 , C07K16/28 , C07K16/3061 , A61K38/00
摘要： Hybrid cell line for producing of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于产生针对所有正常人T细胞上发现的抗原的单克隆抗体的杂交细胞系。 通过将来自免疫Balb / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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4.发明授权
公开(公告)号：US4381295A
公开(公告)日：1983-04-26
申请号：US33639
申请日：1979-04-26
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C07K16/30 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/3061 , C07K16/2812 , A61K38/00 , Y10S435/966 , Y10S530/808
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于在所有正常人辅助T细胞上发现的抗原的单克隆抗体的杂交细胞系。 通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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5.发明授权
公开(公告)号：US4364937A
公开(公告)日：1982-12-21
申请号：US110510
申请日：1980-01-08
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/2806 , A61K38/00 , Y10S435/948 , Y10S530/806 , Y10S530/808 , Y10S530/809 , Y10S530/868
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于在基本上所有正常人T细胞和大约95％正常人胸腺细胞上发现的抗原的单克隆抗体的杂交细胞系。 通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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6.发明授权Monoclonal antibody to a human monocyte antigen and methods of preparing same 失效人单核细胞抗原的单克隆抗体及其制备方法
公开(公告)号：US4364936A
公开(公告)日：1982-12-21
申请号：US110509
申请日：1980-01-08
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P37/00 , C07K14/005 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/28 , A61K38/00 , Y10S530/808
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于在正常人单核细胞和粒细胞上发现的抗原的单克隆抗体的杂交细胞系。 通过将来自免疫的BALB / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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7.发明授权Hybrid cell line for producing monoclonal antibody to a human prothymocyte antigen, antibody, and methods 失效用于产生人胸腺细胞抗原的单克隆抗体的杂交细胞系，抗体和方法
公开(公告)号：US4806349A
公开(公告)日：1989-02-21
申请号：US646545
申请日：1984-09-04
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
CPC分类号： C07K16/2896 , G01N33/56972 , A61K38/00 , Y10S530/808 , Y10S530/809
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于在大约95％的正常人胸腺细胞上发现的用于产生抗原的单克隆抗体的杂交细胞系。 通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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公开(公告)号：US4658020A
公开(公告)日：1987-04-14
申请号：US639554
申请日：1984-08-10
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K38/00 , C07K16/28 , C07K16/30 , G01N33/569 , C07K15/00 , A61K39/395
CPC分类号： G01N33/56972 , C07K16/2812 , C07K16/3061 , A61K38/00
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human helper T cells. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于在所有正常人辅助T细胞上发现的抗原的单克隆抗体的杂交细胞系。 通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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9.发明授权Monoclonal antibody to a human early thymocyte antigen and methods for preparing same 失效人早期胸腺细胞抗原的单克隆抗体及其制备方法
公开(公告)号：US4364934A
公开(公告)日：1982-12-21
申请号：US100071
申请日：1979-12-04
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C12N5/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/2881 , A61K38/00 , Y10S530/808
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 10% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于在大约10％的正常人胸腺细胞上发现的用于产生针对抗原的单克隆抗体的杂交细胞系。 通过将来自免疫的CAF1小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合来形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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公开(公告)号：US4363799A
公开(公告)日：1982-12-14
申请号：US22132
申请日：1979-03-20
申请人： Patrick C. Kung , Gideon Goldstein
发明人： Patrick C. Kung , Gideon Goldstein
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/28 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577 , C12N5/00 , C12N5/02 , C12N15/00 , C12Q1/00 , G01N33/48 , G01N33/68 , G01N33/96
CPC分类号： C07K16/3061 , C07K16/28 , A61K38/00 , Y10S435/948 , Y10S530/806 , Y10S530/808 , Y10S530/809
摘要： Hybrid cell line for production of monoclonal antibody to an antigen found on all normal human T cells. The hybrid is formed by fusing splenocytes from immunized Balb/cJ mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
摘要翻译： 用于产生针对所有正常人T细胞上发现的抗原的单克隆抗体的杂交细胞系。 通过将来自免疫Balb / cJ小鼠的脾细胞与P3X63Ag8U1骨髓瘤细胞融合形成杂交体。 还公开了单克隆抗体的诊断和治疗用途。
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