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公开(公告)号：US07932360B2
公开(公告)日：2011-04-26
申请号：US11593280
申请日：2006-11-06
IPC分类号： C12P21/08 , A61K39/395
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
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公开(公告)号：US07927834B2
公开(公告)日：2011-04-19
申请号：US12221021
申请日：2008-07-29
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
摘要翻译： 本发明提供从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，从而形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。
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公开(公告)号：US20090263864A1
公开(公告)日：2009-10-22
申请号：US12221021
申请日：2008-07-29
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
摘要翻译： 本发明提供从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，从而形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。
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公开(公告)号：US20110177073A1
公开(公告)日：2011-07-21
申请号：US12932719
申请日：2011-03-04
IPC分类号： A61K39/395 , C12P21/00 , C12Q1/02 , C12N5/10 , A61P43/00
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： Provided is methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
摘要翻译： 提供了从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，从而形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。
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公开(公告)号：US07429486B2
公开(公告)日：2008-09-30
申请号：US11593279
申请日：2006-11-06
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
摘要翻译： 本发明提供从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，从而形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。
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公开(公告)号：US07262028B2
公开(公告)日：2007-08-28
申请号：US11039767
申请日：2005-01-18
申请人： Patrick Hendrikus Cornelis Van Berkel , Abraham Bout , Ton Logtenberg , Ronald Hendrik Pieter Brus
发明人： Patrick Hendrikus Cornelis Van Berkel , Abraham Bout , Ton Logtenberg , Ronald Hendrik Pieter Brus
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
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公开(公告)号：US20070054362A1
公开(公告)日：2007-03-08
申请号：US11593280
申请日：2006-11-06
申请人： Patrick Van Berkel , Ronald Brus , Ton Logtenberg , Abraham Bout
发明人： Patrick Van Berkel , Ronald Brus , Ton Logtenberg , Abraham Bout
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
摘要翻译： 本发明提供从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，从而形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。
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公开(公告)号：US09303081B2
公开(公告)日：2016-04-05
申请号：US12932719
申请日：2011-03-04
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： Provided is methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
摘要翻译： 提供了从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，从而形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。
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公开(公告)号：US20070077624A1
公开(公告)日：2007-04-05
申请号：US11593279
申请日：2006-11-06
申请人： Patrick Van Berkel , Ronald Brus , Ton Logtenberg , Abraham Bout
发明人： Patrick Van Berkel , Ronald Brus , Ton Logtenberg , Abraham Bout
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
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公开(公告)号：US20050170398A1
公开(公告)日：2005-08-04
申请号：US11039767
申请日：2005-01-18
IPC分类号： A61K39/00 , C07K14/00 , C07K16/00 , C07K16/10 , C07K16/28 , C07K16/30 , C07K16/32 , C12N15/00 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/567 , C12N5/06 , C12N15/85
CPC分类号： C12P21/005 , A61K39/39558 , C07K16/00 , C07K16/10 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/12 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/56 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2319/30 , Y02P20/582
摘要： The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
摘要翻译： 本发明提供从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，由此形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。
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