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公开(公告)号:US20080188399A1
公开(公告)日:2008-08-07
申请号:US11816317
申请日:2006-02-16
申请人: Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Li Wan , Xiaoping Zhang
发明人: Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Li Wan , Xiaoping Zhang
IPC分类号: A61K38/02 , C07K2/00 , C07C53/00 , A61P31/12 , A61P35/00 , A61P31/04 , C07D305/08 , C07D309/14
摘要: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.
摘要翻译: 肽载体的单分散大分子缀合物组合物与一种或多种效应物和一种或多种治疗剂不可逆地或可逆地缀合,其中至少一种效应物或治疗剂通过水溶性聚合物连接到所述肽载体上的侧链反应性基团上。 通过使用正交和分离的共轭反应获得单分散性。
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公开(公告)号:US07846893B2
公开(公告)日:2010-12-07
申请号:US11816317
申请日:2006-02-16
申请人: Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Li Wan , Xiaoping Zhang
发明人: Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Li Wan , Xiaoping Zhang
摘要: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.
摘要翻译: 肽载体的单分散大分子缀合物组合物与一种或多种效应物和一种或多种治疗剂不可逆地或可逆地缀合,其中至少一种效应物或治疗剂通过水溶性聚合物连接到所述肽载体上的侧链反应性基团上。 通过使用正交和分离的共轭反应获得单分散性。
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公开(公告)号:US09421272B2
公开(公告)日:2016-08-23
申请号:US13255635
申请日:2010-03-16
申请人: Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Matthew Sean Palombo , Xiaoping Zhang
发明人: Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Matthew Sean Palombo , Xiaoping Zhang
IPC分类号: A61K51/00 , A61K39/00 , C12N9/96 , A61K38/00 , C07K16/00 , A61K49/00 , A61K38/54 , A61K47/42 , A61K9/51 , B82Y5/00
CPC分类号: A61K47/42 , A61K9/5169
摘要: This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.
摘要翻译: 本发明提供用于体内递送生物活性剂的多聚体纳米载体,其包含与一种或多种所述生物活性剂可逆地或不可逆地连接的至少两种肽单体,其中所述两种或多种所述肽单体通过可生物降解的双官能部分共价连接 ,以及使用该纳米载体的方法。
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