公开(公告)号：US20140316218A1

公开(公告)日：2014-10-23

申请号：US14260070

申请日：2014-04-23

申请人： Patrick L. Purdon ,  Emery N. Brown ,  ShiNung Ching ,  David A. Boas ,  Maria Angela Franceschini ,  Jason Sutin

发明人： Patrick L. Purdon ,  Emery N. Brown ,  ShiNung Ching ,  David A. Boas ,  Maria Angela Franceschini ,  Jason Sutin

IPC分类号： A61B5/00 ,  A61B5/1455 ,  A61B5/026

CPC分类号： A61B5/4866 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/14553 ,  A61B5/4064 ,  A61B5/4821 ,  A61B5/4836 ,  A61B5/4839 ,  A61B5/7235

摘要： Systems and methods for monitoring and/or controlling a brain state of a subject are provided. In certain embodiments, the method includes acquiring physiological data from sensors including electrophysiological sensors and optical sensors, assembling, using data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject, and identifying, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period. The method also includes computing, using data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process, and estimating, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period. The method further includes controlling a treatment using the response function to generate a target burst suppression state.

摘要翻译： 提供了用于监测和/或控制受试者的脑状态的系统和方法。 在某些实施例中，该方法包括从包括电生理传感器和光学传感器的传感器获取生理数据，使用来自电生理传感器的数据组装指示受试者的大脑活动的时间序列信号，以及使用时间序列 信号，由突发抑制周期和突发周期描述的突发抑制状态。 该方法还包括使用来自光学传感器的数据来计算与突发抑制状态相关联的参数，指示代谢过程和血液动力学过程中的至少一个的参数，以及使用参数，时间序列信号和脉冲串 周期，描述在脉冲串抑制周期期间与脉冲串相关的参数的时间过程的响应函数。 该方法还包括使用响应函数来控制处理以产生目标脉冲串抑制状态。

公开(公告)号：US10383574B2

公开(公告)日：2019-08-20

申请号：US14318277

申请日：2014-06-27

申请人： Patrick L. Purdon ,  Emery N. Brown ,  Laura D. Lewis ,  Brandon M. Westover ,  ShiNung Ching

发明人： Patrick L. Purdon ,  Emery N. Brown ,  Laura D. Lewis ,  Brandon M. Westover ,  ShiNung Ching

IPC分类号： A61B5/0476 ,  A61B5/00 ,  A61B5/0478 ,  A61B5/04

摘要： Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.

公开(公告)号：US20150011907A1

公开(公告)日：2015-01-08

申请号：US14318277

申请日：2014-06-27

申请人： Patrick L. Purdon ,  Emery N. Brown ,  Laura D. Lewis ,  Brandon M. Westover ,  ShiNung Ching

发明人： Patrick L. Purdon ,  Emery N. Brown ,  Laura D. Lewis ,  Brandon M. Westover ,  ShiNung Ching

IPC分类号： A61B5/0476 ,  A61B5/00

CPC分类号： A61B5/6814 ,  A61B5/0478 ,  A61B5/4064 ,  A61B5/4821 ,  A61B5/4839

摘要： Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.

摘要翻译： 提供了用于监测受试者的系统和方法，特别是用于在没有当前条件的情况下推断存在的潜在脑状态。 在一些方面，提供了一种用于监测对象的方法，包括从至少一个传感器接收生理反馈的步骤，所述传感器被配置为从与受检者的大脑相关联的位置获取生理信息，使用所接收的生理反馈组合一组时间序列数据， 以及识别指示突发抑制状态的一组时间序列数据的部分。 该方法还包括识别与从所识别的部分确定的突发模式相关联的脉冲串特征曲线，以及将突发特性与脉冲串配置文件的参考集进行比较。 该方法还包括基于比较来确定基于突发抑制状态的受试者的脑状态的可能性，以及生成指示所确定的大脑状态的可能性的报告。