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公开(公告)号：US10383574B2
公开(公告)日：2019-08-20
申请号：US14318277
申请日：2014-06-27
IPC分类号： A61B5/0476 , A61B5/00 , A61B5/0478 , A61B5/04
摘要： Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.
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公开(公告)号：US20150011907A1
公开(公告)日：2015-01-08
申请号：US14318277
申请日：2014-06-27
IPC分类号： A61B5/0476 , A61B5/00
CPC分类号： A61B5/6814 , A61B5/0478 , A61B5/4064 , A61B5/4821 , A61B5/4839
摘要： Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.
摘要翻译： 提供了用于监测受试者的系统和方法，特别是用于在没有当前条件的情况下推断存在的潜在脑状态。 在一些方面，提供了一种用于监测对象的方法，包括从至少一个传感器接收生理反馈的步骤，所述传感器被配置为从与受检者的大脑相关联的位置获取生理信息，使用所接收的生理反馈组合一组时间序列数据， 以及识别指示突发抑制状态的一组时间序列数据的部分。 该方法还包括识别与从所识别的部分确定的突发模式相关联的脉冲串特征曲线，以及将突发特性与脉冲串配置文件的参考集进行比较。 该方法还包括基于比较来确定基于突发抑制状态的受试者的脑状态的可能性，以及生成指示所确定的大脑状态的可能性的报告。
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3.发明申请SYSTEMS AND METHODS FOR MONITORING BRAIN METABOLISM AND ACTIVITY USING ELECTROENCEPHALOGRAM AND OPTICAL IMAGING 审中-公开用于监测脑代谢和使用电化学和光学成像的活性的系统和方法公开(公告)号：US20140316218A1
公开(公告)日：2014-10-23
申请号：US14260070
申请日：2014-04-23
申请人： Patrick L. Purdon , Emery N. Brown , ShiNung Ching , David A. Boas , Maria Angela Franceschini , Jason Sutin
发明人： Patrick L. Purdon , Emery N. Brown , ShiNung Ching , David A. Boas , Maria Angela Franceschini , Jason Sutin
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/026
CPC分类号： A61B5/4866 , A61B5/0075 , A61B5/0261 , A61B5/0476 , A61B5/14553 , A61B5/4064 , A61B5/4821 , A61B5/4836 , A61B5/4839 , A61B5/7235
摘要： Systems and methods for monitoring and/or controlling a brain state of a subject are provided. In certain embodiments, the method includes acquiring physiological data from sensors including electrophysiological sensors and optical sensors, assembling, using data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject, and identifying, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period. The method also includes computing, using data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process, and estimating, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period. The method further includes controlling a treatment using the response function to generate a target burst suppression state.
摘要翻译： 提供了用于监测和/或控制受试者的脑状态的系统和方法。 在某些实施例中，该方法包括从包括电生理传感器和光学传感器的传感器获取生理数据，使用来自电生理传感器的数据组装指示受试者的大脑活动的时间序列信号，以及使用时间序列 信号，由突发抑制周期和突发周期描述的突发抑制状态。 该方法还包括使用来自光学传感器的数据来计算与突发抑制状态相关联的参数，指示代谢过程和血液动力学过程中的至少一个的参数，以及使用参数，时间序列信号和脉冲串 周期，描述在脉冲串抑制周期期间与脉冲串相关的参数的时间过程的响应函数。 该方法还包括使用响应函数来控制处理以产生目标脉冲串抑制状态。
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4.发明申请SYSTEM AND METHOD FOR MONITORING ANESTHESIA AND SEDATION USING MEASURES OF BRAIN COHERENCE AND SYNCHRONY 审中-公开使用大脑相干和同步的措施来监测麻醉和分离的系统和方法公开(公告)号：US20140316217A1
公开(公告)日：2014-10-23
申请号：US14260006
申请日：2014-04-23
IPC分类号： A61B5/00 , A61B5/145 , A61B5/0476
CPC分类号： A61B5/4821 , A61B5/02 , A61B5/0476 , A61B5/048 , A61B5/14542 , A61B5/7264 , A61B5/7275
摘要： A system and method for monitoring and controlling the administration of at least one drug having anesthetic properties are provided. In certain embodiments, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of low frequency signals, and determining, from the plurality of low frequency signals, at least one of coherence information and synchrony information. The method can also include identifying, using the at least one of the coherence information and the synchrony information, spatiotemporal signatures indicative of at least one of a current state and a predicted future state of the patient consistent with the administration of at least one drug having anesthetic properties and generating a report indicating at least one of the current state and the predicted future state of the patient induced by the drug.
摘要翻译： 提供了用于监测和控制至少一种具有麻醉性质的药物的给药的系统和方法。 在某些实施例中，该方法包括将从放置在对象上的多个传感器获得的生理数据组合成一组时间序列数据，从时间序列数据组中分离出多个低频信号，并且确定 来自所述多个低频信号中的至少一个相干信息和同步信息。 该方法还可以包括使用至少一个相干信息和同步信息来识别指示患者的当前状态和预测的未来状态中的至少一个的时空签名，与至少一种具有 产生指示由药物引起的患者的当前状态和预测未来状态中的至少一个的报告。
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5.发明申请SYSTEM AND METHOD FOR TRACKING BRAIN STATES DURING ADMINISTRATION OF ANESTHESIA 审中-公开在麻醉管理期间跟踪脑状态的系统和方法公开(公告)号：US20140187973A1
公开(公告)日：2014-07-03
申请号：US14115682
申请日：2012-05-07
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/0205 , A61B5/02 , A61B5/0476 , A61B5/048 , A61B5/04845 , A61B5/4821 , A61B5/7264 , G06K9/00496
摘要： A method and system for determining the state of a patients brain under anesthesia. The present invention recognizes that anesthesia compounds induce different signatures in physiological characteristics of the patient under anesthesia and aids interpretation of physiological characteristics and signatures therein based on a selected anesthesia compound. The present invention aids the monitoring and/or interpreting of the physiological characteristics to a state of the patient's brain.
摘要翻译： 用于确定麻醉患者脑部状态的方法和系统。 本发明认识到麻醉化合物在麻醉下诱导患者的生理特征不同的特征，并且基于选择的麻醉化合物帮助解释其中的生理特征和特征。 本发明有助于将生理特征监测和/或解释为患者大脑的状态。
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6.发明申请Systems and Methods For Improved Brain Monitoring During General Anesthesia And Sedation 审中-公开在一般麻醉和镇静期间改善脑部监测的系统和方法公开(公告)号：US20150080754A1
公开(公告)日：2015-03-19
申请号：US14485523
申请日：2014-09-12
CPC分类号： A61B5/4821 , A61B5/04012 , A61B5/0476 , A61B5/048 , A61B5/7257 , G16H15/00
摘要： Systems and method for age-compensated monitoring of a patient experiencing administration of at least one drug having anesthetic properties are provided. In one embodiment, a system includes a plurality of sensors configured to acquire physiological data from the patient and at least one processor configured to receive the physiological data from the plurality of sensors, and determine, from the physiological data, signal markers indicative of an apparent or likely patient age. The at least one processor is also configured to at least one of scale and regulate the physiological data using at least the apparent patient age to create age-compensated data, and generate a report including the age-compensated data.
摘要翻译： 提供了经历至少一种具有麻醉性质药物的患者的年龄补偿监测的系统和方法。 在一个实施例中，系统包括被配置为从患者获取生理数据的多个传感器和被配置为从多个传感器接收生理数据的至少一个处理器，并且从生理数据确定指示表观的信号标记 或可能患者年龄。 所述至少一个处理器还被配置为使用至少明显的患者年龄来规模和调节生理数据中的至少一个，以产生年龄补偿数据，并且生成包括年龄补偿数据的报告。
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7.发明申请SYSTEM AND METHOD FOR ESTIMATING HIGH TIME-FREQUENCY RESOLUTION EEG SPECTROGRAMS TO MONITOR PATIENT STATE 审中-公开用于估计高频分辨率脑电图监测患者状态的系统和方法公开(公告)号：US20140323897A1
公开(公告)日：2014-10-30
申请号：US14261166
申请日：2014-04-24
申请人： Emery N. Brown , Patrick L. Purdon , Demba Ba , Behtash Babadi
发明人： Emery N. Brown , Patrick L. Purdon , Demba Ba , Behtash Babadi
IPC分类号： A61B5/00
CPC分类号： A61B5/4821 , A61B5/048
摘要： A system and method for monitoring a patient includes a sensor configured to acquire physiological data from a patient and a processor configured to receive the physiological data from the at least one sensor. The processor is also configured to apply a spectral estimation framework that utilizes structured time-frequency representations defined by imposing, to the physiological data, a prior distributions on a time-frequency plane that enforces spectral estimates that are smooth in time and sparse in a frequency domain. The processor is further configured to perform an iteratively re-weighted least squares algorithm to perform yield a denoised time-varying spectral decomposition of the physiological data and generate a report indicating a physiological state of the patient.
摘要翻译： 用于监测患者的系统和方法包括被配置为从患者获取生理数据的传感器和被配置为从所述至少一个传感器接收生理数据的处理器。 处理器还被配置为应用频谱估计框架，其利用结构化时间频率表示，该结构化时间频率表示是通过对生理数据施加在时间 - 频率平面上的先前分布来实施的，其中频谱估计在时间上是平滑的并且在频率上是稀疏的 域。 处理器还被配置为执行迭代重新加权的最小二乘法算法来执行产生生理数据的去噪时变频谱分解并生成指示患者的生理状态的报告。
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公开(公告)号：US10602978B2
公开(公告)日：2020-03-31
申请号：US14485523
申请日：2014-09-12
IPC分类号： A61B5/0476 , A61B5/00 , A61B5/04 , A61B5/048 , G16H15/00
摘要： Systems and method for age-compensated monitoring of a patient experiencing administration of at least one drug having anesthetic properties are provided. In one embodiment, a system includes a plurality of sensors configured to acquire physiological data from the patient and at least one processor configured to receive the physiological data from the plurality of sensors, and determine, from the physiological data, signal markers indicative of an apparent or likely patient age. The at least one processor is also configured to at least one of scale and regulate the physiological data using at least the apparent patient age to create age-compensated data, and generate a report including the age-compensated data.
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9.发明申请SYSTEM AND METHOD FOR MONITORING AND CONTROLLING A STATE OF A PATIENT DURING AND AFTER ADMINISTRATION OF ANESTHETIC COMPOUND 审中-公开用于监测和控制麻醉药物治疗期间和之后的患者状态的系统和方法公开(公告)号：US20140180160A1
公开(公告)日：2014-06-26
申请号：US14151412
申请日：2014-01-09
申请人： Emery N. Brown , Patrick L. Purdon
发明人： Emery N. Brown , Patrick L. Purdon
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0476
CPC分类号： A61B5/4821 , A61B5/04017 , A61B5/0478 , A61B5/4839 , A61B5/6868 , A61B5/725
摘要： A system and method for monitoring and controlling the administration of at least one drug having anesthetic properties are provided. The method includes arranging a plurality of sensors configured to acquire physiological data from a patient and reviewing the physiological data from the plurality of sensors and an indication from a user interface. The method also includes assembling the physiological data into sets of time-series data and analyzing the sets of time-series data to determine signature profiles consistent with the administration of at least one drug. The method further includes identifying, using signature profiles, at least one of a current state and a predicted future state of the patient, controlling the administration of the least one drug to attain the predicted future state, and then generating a report including information regarding at least one of the current state and the predicted future state of the patient induced by the drug.
摘要翻译： 提供了用于监测和控制至少一种具有麻醉性质的药物的给药的系统和方法。 所述方法包括布置多个传感器，所述多个传感器被配置为从患者获取生理数据并且从所述多个传感器中检查所述生理数据以及来自用户界面的指示。 该方法还包括将生理数据组合成一组时间序列数据并分析时间序列数据集以确定符合至少一种药物施用的特征谱。 该方法还包括使用签名简档来识别患者的当前状态和预测未来状态中的至少一个，控制至少一种药物的管理以获得预测的未来状态，然后生成包括关于在 目前的状态中最少的一个和由药物引起的患者的预测未来状态。
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10.发明申请System and Method for Monitoring Level of Dexmedatomidine-Induced Sedation 审中-公开Dexmedatomidine诱导镇静水平的系统和方法公开(公告)号：US20140323898A1
公开(公告)日：2014-10-30
申请号：US14261188
申请日：2014-04-24
IPC分类号： A61B5/00
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/16
摘要： A system and method for monitoring a patient experiencing an administration of at least one anesthetic drug. In certain embodiments, the method includes arranging sensors configured to acquire physiological data from a patient and reviewing the physiological data from the sensors and an indication received from an input. The method also includes assembling the physiological data into sets of time-series data and determining, from the sets of time-series data, a first set of signals in a first frequency range and a second set of signals in a second frequency range, the first set of signals describing a transient oscillation signature and the second set of signals describing a target wave signature. The method further includes identifying, using the transient oscillation and target wave signatures, a degree of sedation consistent with the administration of the anesthetic drug, and generating a report indicative of the degree of sedation induced by the drug.
摘要翻译： 一种用于监测经历至少一种麻醉药物的给药的患者的系统和方法。 在某些实施例中，该方法包括配置用于从患者获取生理数据并且检查来自传感器的生理数据和从输入接收的指示的传感器。 该方法还包括将生理数据组合成一组时间序列数据，并从该组时间序列数据中确定第一频率范围中的第一组信号和在第二频率范围内的第二组信号， 描述瞬态振荡特征的第一组信号和描述目标波特征的第二组信号。 该方法还包括使用瞬时振荡和目标波特征识别与施用麻醉药物一致的镇静程度，以及产生指示由药物引起的镇静程度的报告。
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