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    Methods for Treating Sleep Apnea Via Renal Denervation
    2.
    发明申请
    Methods for Treating Sleep Apnea Via Renal Denervation 审中-公开
    通过肾去神经治疗睡眠呼吸暂停的方法

    公开(公告)号：US20110208175A1

    公开(公告)日：2011-08-25

    申请号：US13034610

    申请日：2011-02-24

    申请人： Paul A. Sobotka ,  Neil C. Barman

    发明人： Paul A. Sobotka ,  Neil C. Barman

    IPC分类号： A61B18/02 ,  A61B18/18

    CPC分类号： A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61N1/36057 ,  A61N1/36085 ,  A61N1/36117

    摘要： Methods for therapeutic renal neuromodulation are disclosed herein. One aspect of the present application, for example, is directed to methods that block, reduce and/or inhibit renal sympathetic nerve activity to achieve a reduction in central sympathetic tone. Renal sympathetic nerve activity may be altered or modulated along the afferent and/or efferent pathway. The achieved reduction in central sympathetic tone may carry several therapeutic benefits across many disease states, including, without limitation, sleep apnea.

    摘要翻译： 本文公开了治疗性肾神经调节的方法。 本申请的一个方面，例如，涉及阻断，减少和/或抑制肾交感神经活性以实现中枢交感神经张力降低的方法。 肾交感神经活动可以沿传入和/或传出途径改变或调节。 实现中枢交感神经紧张的减少可能在许多疾病状态中具有几种治疗益处，包括但不限于睡眠呼吸暂停。

    Methods for Treating sleep apnea via renal Denervation
    3.
    发明申请
    Methods for Treating sleep apnea via renal Denervation 审中-公开
    通过肾去神经治疗睡眠呼吸暂停的方法

    公开(公告)号：US20110208173A1

    公开(公告)日：2011-08-25

    申请号：US13034602

    申请日：2011-02-24

    申请人： Paul A. Sobotka ,  Neil C. Barman

    发明人： Paul A. Sobotka ,  Neil C. Barman

    IPC分类号： A61B18/02 ,  A61B17/00

    CPC分类号： A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61N1/36057 ,  A61N1/36085 ,  A61N1/36117

    摘要： Methods for therapeutic renal neuromodulation are disclosed herein. One aspect of the present application, for example, is directed to methods that block, reduce and/or inhibit renal sympathetic nerve activity to achieve a reduction in central sympathetic tone. Renal sympathetic nerve activity may be altered or modulated along the afferent and/or efferent pathway. The achieved reduction in central sympathetic tone may carry several therapeutic benefits across many disease states, including, but without limitation, insulin resistance, diabetes and/or metabolic syndrome.

    摘要翻译： 本文公开了治疗性肾神经调节的方法。 本申请的一个方面，例如，涉及阻断，减少和/或抑制肾交感神经活性以实现中枢交感神经张力降低的方法。 肾交感神经活动可以沿传入和/或传出途径改变或调节。 实现的中枢交感神经紧张的减少可能在许多疾病状态中具有若干治疗益处，包括但不限于胰岛素抵抗，糖尿病和/或代谢综合征。

    METHODS AND APPARATUS FOR RENAL NEUROMODULATION VIA STEREOTACTIC RADIOTHERAPY
    5.
    发明申请
    METHODS AND APPARATUS FOR RENAL NEUROMODULATION VIA STEREOTACTIC RADIOTHERAPY 审中-公开
    通过立体放射治疗进行肾神经调节的方法和装置

    公开(公告)号：US20110200171A1

    公开(公告)日：2011-08-18

    申请号：US13009748

    申请日：2011-01-19

    申请人： Robert J. Beetel ,  Neil C. Barman ,  Benjamin J. Clark ,  Paul Friedrichs ,  Kenneth J. Michlitsch ,  Karun D. Naga ,  Andrew Wu ,  Denise Zarins

    发明人： Robert J. Beetel ,  Neil C. Barman ,  Benjamin J. Clark ,  Paul Friedrichs ,  Kenneth J. Michlitsch ,  Karun D. Naga ,  Andrew Wu ,  Denise Zarins

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1042 ,  A61B6/506 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61N5/1067 ,  A61N7/02 ,  A61N2005/1061

    摘要： The present disclosure describes methods and apparatus for renal neuromodulation via stereotactic radiotherapy for the treatment of hypertension, heart failure, chronic kidney disease, diabetes, insulin resistance, metabolic disorder or other ailments. Renal neuromodulation may be achieved by locating renal nerves and then utilizing stereotactic radiotherapy to expose the renal nerves to a radiation dose sufficient to reduce neural activity. A neural location element may be provided for locating target renal nerves, and a stereotactic radiotherapy system may be provided for exposing the located renal nerves to a radiation dose sufficient to reduce the neural activity, with reduced or minimized radiation exposure in adjacent tissue. Renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as at pre-ganglionic positions.

    摘要翻译： 本公开描述了通过立体定向放射治疗高血压，心力衰竭，慢性肾脏疾病，糖尿病，胰岛素抵抗，代谢紊乱或其它疾病的肾神经调节的方法和装置。 肾神经调节可以通过定位肾神经，然后利用立体定向放射治疗来将肾神经暴露于足以减少神经活动的辐射剂量来实现。 可以提供用于定位目标肾神经的神经定位元件，并且可以提供立体定向放射治疗系统，用于将位于所述肾神经的辐射剂量暴露于足以减少或最小化相邻组织中的辐射暴露的神经活动的辐射剂量。 肾神经可能位于神经节水平和/或神经节后位置以及神经节前位置。

    CATHETER ASSEMBLIES FOR NEUROMODULATION PROXIMATE A BIFURCATION OF A RENAL ARTERY AND ASSOCIATED SYSTEMS AND METHODS
    6.
    发明申请
    CATHETER ASSEMBLIES FOR NEUROMODULATION PROXIMATE A BIFURCATION OF A RENAL ARTERY AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
    用于神经调节的导管组件可以使后续动脉和相关系统和方法的分叉

    公开(公告)号：US20130289682A1

    公开(公告)日：2013-10-31

    申请号：US13458877

    申请日：2012-04-27

    申请人： Neil C. Barman ,  Robert J. Beetel ,  Benjamin J. Clark ,  Andrew Wu ,  Maria G. Aboytes ,  Denise Zarins

    发明人： Neil C. Barman ,  Robert J. Beetel ,  Benjamin J. Clark ,  Andrew Wu ,  Maria G. Aboytes ,  Denise Zarins

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0558 ,  A61B18/1492 ,  A61N1/36007

    摘要： Catheter assemblies for neuromodulation proximate a renal artery bifurcation and associated systems and methods are disclosed herein. A catheter assembly configured in accordance with a particular embodiment of the present technology can include a shaft having a proximal portion, a distal portion, and two therapeutic arms extending from the distal portion. The shaft can be configured to deliver the distal portion to a treatment site proximate a branch point or bifurcation in a renal blood vessel. The therapeutic arms can include energy delivery elements that are configured to deliver the therapeutically-effective energy to renal nerves proximate the branch point.

    摘要翻译： 在肾动脉分叉附近神经调节的导管组件以及相关系统和方法在本文中公开。 根据本技术的特定实施例构造的导管组件可以包括具有近端部分，远侧部分和从远端部分延伸的两个治疗臂的轴。 轴可以被配置为将远端部分输送到靠近肾血管中的分支点或分叉处的治疗部位。 治疗臂可以包括被配置为将治疗有效能量递送到靠近分支点的肾神经的能量递送元件。