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公开(公告)号：US06500844B1
公开(公告)日：2002-12-31
申请号：US09590487
申请日：2000-06-08
IPC分类号： A61K31445
CPC分类号： C07D401/08 , C07D211/58 , C07D413/08
摘要： The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R7, R8, X, Y, Z, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
摘要翻译： 本发明涉及可用作趋化因子受体活性调节剂的式I化合物（其中R1，R2，R3，R7，R8，X，Y，Z，x和y如本文所定义）。 特别地，这些化合物可用作趋化因子受体CCR-5和/或CCR-3的调节剂。
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公开(公告)号：US06476054B1
公开(公告)日：2002-11-05
申请号：US09690622
申请日：2000-10-17
申请人： Charles G. Caldwell , Paul E. Finke , Malcolm Maccoss , Sander G. Mills , Bryan Oates , Dooseop Kim , Shankaran Kothandaraman , Liping Wang
发明人： Charles G. Caldwell , Paul E. Finke , Malcolm Maccoss , Sander G. Mills , Bryan Oates , Dooseop Kim , Shankaran Kothandaraman , Liping Wang
IPC分类号： A61K31445
CPC分类号： C07D231/12 , C07D211/56 , C07D211/58 , C07D233/56 , C07D249/08 , C07D401/06 , C07D405/06 , C07D409/06
摘要： The present invention is directed to cyclic amines of the formula I: (wherein R1, R2, R3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
摘要翻译： 本发明涉及式I的环胺（其中R1，R2，R3，m和n如本文所定义），其可用作趋化因子受体活性的调节剂。 特别地，这些化合物可用作趋化因子受体CCR-1，CCR-2，CCR-2A，CCR-2B，CCR-3，CCR-4，CCR-5，CXCR-3和/或CXCR- 4。
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公开(公告)号：US06136827A
公开(公告)日：2000-10-24
申请号：US120010
申请日：1998-07-21
申请人： Charles G. Caldwell , Paul E. Finke , Malcolm Maccoss , Laura C. Meurer , Sander G. Mills , Bryan Oates
发明人： Charles G. Caldwell , Paul E. Finke , Malcolm Maccoss , Laura C. Meurer , Sander G. Mills , Bryan Oates
IPC分类号： A61K31/445 , C07D211/56
CPC分类号： C07D211/34 , C07D211/10 , C07D211/18 , C07D211/22 , C07D211/56 , C07D401/04 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/04
摘要： The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
摘要翻译： 本发明涉及式I的环胺（其中R1，R2，R3，m和n如本文所定义），其可用作趋化因子受体活性的调节剂。 特别地，这些化合物可用作趋化因子受体CCR-1，CCR-2，CCR-2A，CCR-2B，CCR-3，CCR-4，CCR-5，CXCR-3和/或CXCR- 4。
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公开(公告)号：US06593346B2
公开(公告)日：2003-07-15
申请号：US10075163
申请日：2002-02-14
申请人： Paul E. Finke , Kerry A. Hilfiker , Malcolm MacCoss , Kevin T. Chapman , Jennifer L. Loebach , Sander G. Mills , Ravi N. Guthikonda , Shrenik K. Shah , Dooseop Kim , Dong-Ming Shen , Bryan Oates
发明人： Paul E. Finke , Kerry A. Hilfiker , Malcolm MacCoss , Kevin T. Chapman , Jennifer L. Loebach , Sander G. Mills , Ravi N. Guthikonda , Shrenik K. Shah , Dooseop Kim , Dong-Ming Shen , Bryan Oates
IPC分类号： A61K31445
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/20 , C07D211/24 , C07D211/34 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The present invention is directed to compounds of the formula I: (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
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公开(公告)号：US06538002B1
公开(公告)日：2003-03-25
申请号：US09591631
申请日：2000-06-08
申请人： Paul E. Finke , Malcolm Maccoss , Sander G. Mills , Bryan Oates
发明人： Paul E. Finke , Malcolm Maccoss , Sander G. Mills , Bryan Oates
IPC分类号： A01N4340
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/48 , C07D409/08 , C07D495/10 , Y10S514/824 , Y10S514/826 , Y10S514/918
摘要： The present in to s directed to compounds of the formula I: (wherein R1, R2, R3, R7, R8, X, Y, Z, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
摘要翻译： 本发明涉及可用作趋化因子受体活性调节剂的式I化合物（其中R1，R2，R3，R7，R8，X，Y，Z，x和y如本文所定义）。 特别地，这些化合物可用作趋化因子受体CCR-5和/或CCR-3的调节剂。
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公开(公告)号：US06432981B1
公开(公告)日：2002-08-13
申请号：US09590484
申请日：2000-06-08
申请人： Paul E. Finke , Kerry A. Hilfiker , Jennifer L. Loebach , Malcolm Maccoss , Sander G. Mills , Dong-Ming Shen , Bryan Oates
发明人： Paul E. Finke , Kerry A. Hilfiker , Jennifer L. Loebach , Malcolm Maccoss , Sander G. Mills , Dong-Ming Shen , Bryan Oates
IPC分类号： A61K31445
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/24 , C07D211/34 , C07D401/06 , C07D401/12 , C07D413/06 , C07D417/04 , C07D471/04
摘要： The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
摘要翻译： 本发明涉及可用作趋化因子受体活性调节剂的式I化合物（其中R 1，R 2，R 3，R 4，R 5，R 7，R 8，X，n，x和y如本文所定义）。 特别地，这些化合物可用作趋化因子受体CCR-5和/或CCR-3的调节剂。
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公开(公告)号：US06472410B1
公开(公告)日：2002-10-29
申请号：US09590318
申请日：2000-06-08
申请人： Paul E. Finke , Kevin T. Chapman , Malcolm Maccoss , Sander G. Mills , Jennifer L. Loebach , Bryan Oates
发明人： Paul E. Finke , Kevin T. Chapman , Malcolm Maccoss , Sander G. Mills , Jennifer L. Loebach , Bryan Oates
IPC分类号： A61K314468
CPC分类号： C07D401/08 , C07D211/58 , Y02P20/582
摘要： The present invention is directed to compounds of the formula I: (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
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公开(公告)号：US06358979B1
公开(公告)日：2002-03-19
申请号：US09590750
申请日：2000-06-08
申请人： Paul E. Finke , Kerry A. Hilfiker , Malcolm MacCoss , Kevin T. Chapman , Jennifer L. Loebach , Sander G. Mills , Ravi N. Guthikonda , Shrenik K. Shah , Dooseop Kim , Dong-Ming Shen , Bryan Oates
发明人： Paul E. Finke , Kerry A. Hilfiker , Malcolm MacCoss , Kevin T. Chapman , Jennifer L. Loebach , Sander G. Mills , Ravi N. Guthikonda , Shrenik K. Shah , Dooseop Kim , Dong-Ming Shen , Bryan Oates
IPC分类号： A61K31445
CPC分类号： C07D401/04 , C07D211/14 , C07D211/18 , C07D211/20 , C07D211/24 , C07D211/34 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D471/04 , Y02P20/582
摘要： The present invention is directed to compounds of the formula I: (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.
摘要翻译： 本发明涉及可用作趋化因子受体活性调节剂的式I化合物（其中R 1，R 3，R 4，R 5，R 6，R 7，R 8，X，n，x和y如本文所定义）。 特别地，这些化合物可用作趋化因子受体CCR-5和/或CCR-3的调节剂。
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公开(公告)号：US6140349A
公开(公告)日：2000-10-31
申请号：US241486
申请日：1999-02-01
申请人： Charles G. Caldwell , Malcolm Maccoss , Paul E. Finke , Sander G. Mills , Bryan Oates , Shankaran Kothandaraman , Dooseop Kim , Liping Wang
发明人： Charles G. Caldwell , Malcolm Maccoss , Paul E. Finke , Sander G. Mills , Bryan Oates , Shankaran Kothandaraman , Dooseop Kim , Liping Wang
IPC分类号： C07D211/56 , C07D211/58 , C07D401/06 , C07D405/06 , C07D409/06 , C07D521/00 , A61K31/445 , C07D409/10
CPC分类号： C07D231/12 , C07D211/56 , C07D211/58 , C07D233/56 , C07D249/08 , C07D401/06 , C07D405/06 , C07D409/06
摘要： The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
摘要翻译： 本发明涉及式I的环胺（其中R1，R2，R3，m和n如本文所定义），其可用作趋化因子受体活性的调节剂。 特别地，这些化合物可用作趋化因子受体CCR-1，CCR-2，CCR-2A，CCR-2B，CCR-3，CCR-4，CCR-5，CXCR-3和/或CXCR- 4。
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10.发明申请公开(公告)号：US20090098130A1
公开(公告)日：2009-04-16
申请号：US11969850
申请日：2008-01-04
申请人： Curt W. BRADSHAW , Sukumar Sakamuri , Yanwen Fu , Bryan Oates , Joel Desharnais , David Tumelty
发明人： Curt W. BRADSHAW , Sukumar Sakamuri , Yanwen Fu , Bryan Oates , Joel Desharnais , David Tumelty
CPC分类号： C07K14/605 , A61K47/6811 , A61K47/6843
摘要： The present invention provides GA targeting compounds which comprise GA targeting agent-linker conjugates linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.
摘要翻译： 本发明提供了GA靶向化合物，其包含与抗体的结合位点连接的GA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括预防或治疗糖尿病或糖尿病相关病症的方法。
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