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    Management and control of multi-layer networks
    1.
    发明授权
    Management and control of multi-layer networks 有权
    多层网络的管理与控制

    公开(公告)号：US07269185B2

    公开(公告)日：2007-09-11

    申请号：US09862861

    申请日：2001-05-22

    申请人： Paul Kirkby ,  Michael Heffernan ,  David Ireland ,  Peter Hamer ,  Radhakrishnan Kadengal

    发明人： Paul Kirkby ,  Michael Heffernan ,  David Ireland ,  Peter Hamer ,  Radhakrishnan Kadengal

    IPC分类号： H04J3/16 ,  H04J14/02 ,  G06F15/173 ,  G06F9/46

    CPC分类号： H04L47/822 ,  H04L41/5022 ,  H04L41/5077 ,  H04L47/15 ,  H04L47/24 ,  H04L47/70 ,  H04L47/745 ,  H04L47/765 ,  H04L47/781 ,  H04L47/782 ,  H04L47/801 ,  H04L47/805 ,  H04L47/808 ,  H04L47/829

    摘要： A communications network has multiple resource-allocation layers and incorporates a management structure for allocating resources to allocate resources requested by a first layer of said layers from a second of said layers. At a first layer, the management structure provides an indication to a second layer of the required resources that are to be allocated from the second layer. The second layer automatically offers the required resource together with a condition for use of those resources. This condition includes a notional price factor which is dependent on current demand. Under the control of the manager, the first layer determines if the condition for use of the offered resources is acceptable and, if so, automatically accepts the offered resources from the second layer. In a preferred embodiment, ingress to an underlying multi-wavelength transport layer of the network is controlled via a virtual port which allocates traffic to real ports one for each wavelength supported by the transport layer.

    摘要翻译： 通信网络具有多个资源分配层，并且包括管理结构，用于分配资源以分配来自第二层的所述层的第一层所请求的资源。 在第一层，管理结构向第二层提供要从第二层分配的所需资源的指示。 第二层自动提供所需资源以及使用这些资源的条件。 这种情况包括依赖于当前需求的名义价格因素。 在管理者的控制下，第一层确定所提供资源的使用条件是否可以接受，如果是，则自动从第二层接受提供的资源。 在优选实施例中，通过虚拟端口来控制进入网络的底层多波长传输层，虚拟端口为传输层支持的每个波长分配一个流量到实际端口。

    Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof
    3.
    发明授权
    Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof 有权
    对羟基米那普兰的立体异构体及其使用方法

    公开(公告)号：US07038085B2

    公开(公告)日：2006-05-02

    申请号：US10691465

    申请日：2003-10-22

    申请人： Roman V. Rariy ,  Michael Heffernan ,  Stephen L. Buchwald ,  Timothy M. Swager

    发明人： Roman V. Rariy ,  Michael Heffernan ,  Stephen L. Buchwald ,  Timothy M. Swager

    IPC分类号： C07C233/05 ,  A61K31/165

    CPC分类号： C07C237/24 ,  C07B2200/07 ,  C07C2601/02

    摘要： The present invention relates generally to the enantiomers of para-hydroxy-milnacipran or congeners thereof. Biological assays revealed that racemic para-hydroxy-milnacipran is approximately equipotent in inhibiting serotonin and norepinephrine uptake (IC50=28.6 nM for norepinephrine, IC50=21.7 nM for serotonin). Interestingly, (+)-para-hydroxy-milnacipran is a more potent inhibitor of norepinephrine uptake than serotonin uptake (IC50=10.3 nM for norepinephrine, IC50=22 nM for serotonin). In contrast, (−)-para-hydroxy-milnacipran is a more potent inhibitor of serotonin uptake compared to norepinephrin uptake (IC50=88.5 nM for norepinephrine, IC50=40.3 nM for serotonin). The invention also relates to salts and prodrug forms of the aforementioned compounds. In certain embodiments, the compounds of the present invention and a pharmaceutically acceptable excipient are combined to prepare a formulation for administration to a patient. Finally, the present invention relates to methods of treating mammals suffering from various afflictions, e.g., depression, chronic pain, or fibromyalgia, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of the present invention.

    摘要翻译： 本发明一般涉及对羟基 - 米那普兰或其同系物的对映异构体。 生物测定显示外消旋的对羟基 - 米那普仑在抑制5-羟色胺和去甲肾上腺素摄取方面几乎是等量的（对于5-羟色胺，对于去甲肾上腺素为IC 50 N = 28.7nM，对于5-羟色胺为131.7nM） 。 有趣的是，（+） - 对羟基 - 米那普仑是去甲肾上腺素摄取的更有效的抑制剂，而不是5-羟色胺摄取（去甲肾上腺素（IC 50）= 22nM 用于5-羟色胺）。 相比之下，与去甲肾上腺素摄取相比，（ - ） - 对羟基 - 米那普仑是一种更有效的5-羟色胺摄取抑制剂，对于去甲肾上腺素，IC 50 <= 50> = 对于5-羟色胺为40.3nM）。 本发明还涉及上述化合物的盐和前药形式。 在某些实施方案中，将本发明的化合物和药学上可接受的赋形剂混合以制备用于给予患者的制剂。 最后，本发明涉及治疗患有各种痛苦，例如抑郁症，慢性疼痛或纤维肌痛的哺乳动物的方法，包括向有需要的哺乳动物施用治疗有效量的本发明化合物。

    Technique for enabling a plurality of software components to communicate in a software component matrix environment
    4.
    发明授权
    Technique for enabling a plurality of software components to communicate in a software component matrix environment 有权
    用于使多个软件组件能够在软件组件矩阵环境中进行通信的技术

    公开(公告)号：US08341218B2

    公开(公告)日：2012-12-25

    申请号：US13334375

    申请日：2011-12-22

    申请人： Martin Jan Soukup ,  Gregory Hughes ,  Michael Heffernan

    发明人： Martin Jan Soukup ,  Gregory Hughes ,  Michael Heffernan

    IPC分类号： G06F15/16

    CPC分类号： H04L67/16 ,  G06F9/541 ,  G06F9/547 ,  H04L67/42

    摘要： A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.

    摘要翻译： 公开了一种使多个软件组件能够在软件组件矩阵环境中进行通信的技术。 在一个特定示例性实施例中，该技术可以通过使多个软件组件能够在软件组件矩阵环境中进行通信的方法来实现，该方法包括以下步骤：在客户端侧对请求进行编码; 通过通信接口将请求传送到服务器端的服务器; 将所述请求与在所述服务器侧支持的多个操作进行比较; 确定服务器端是否存在功能匹配; 以及响应于经由所述通信接口的所述请求，将包括所述功能匹配的响应返回给所述客户端，其中所述响应被映射到客户端的数据模型。

    TECHNIQUE FOR ENABLING A PLURALITY OF SOFTWARE COMPONENTS TO COMMUNICATE IN A SOFTWARE COMPONENT MATRIX ENVIRONMENT
    5.
    发明申请
    TECHNIQUE FOR ENABLING A PLURALITY OF SOFTWARE COMPONENTS TO COMMUNICATE IN A SOFTWARE COMPONENT MATRIX ENVIRONMENT 有权
    实现软件组件在软件组件矩阵环境中通用的大量软件组件的技术

    公开(公告)号：US20120102100A1

    公开(公告)日：2012-04-26

    申请号：US13334375

    申请日：2011-12-22

    申请人： Martin Soukup ,  Gregory Hughes ,  Michael Heffernan

    发明人： Martin Soukup ,  Gregory Hughes ,  Michael Heffernan

    IPC分类号： G06F15/16

    CPC分类号： H04L67/16 ,  G06F9/541 ,  G06F9/547 ,  H04L67/42

    摘要： A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.

    摘要翻译： 公开了一种使多个软件组件能够在软件组件矩阵环境中进行通信的技术。 在一个特定示例性实施例中，该技术可以通过使多个软件组件能够在软件组件矩阵环境中进行通信的方法来实现，该方法包括以下步骤：在客户端侧对请求进行编码; 通过通信接口将请求传送到服务器端的服务器; 将所述请求与在所述服务器侧支持的多个操作进行比较; 确定服务器端是否存在功能匹配; 以及响应于经由所述通信接口的所述请求，将包括所述功能匹配的响应返回给所述客户端，其中所述响应被映射到客户端的数据模型。

    Pulsatile release compositions of milnacipran
    7.
    发明申请
    Pulsatile release compositions of milnacipran 审中-公开
    米那普仑的脉冲释放组合物

    公开(公告)号：US20060003004A1

    公开(公告)日：2006-01-05

    申请号：US11192697

    申请日：2005-07-29

    申请人： Jane Hirsh ,  Roman Rariy ,  Michael Heffernan

    发明人： Jane Hirsh ,  Roman Rariy ,  Michael Heffernan

    IPC分类号： A61K9/22

    CPC分类号： A61K9/4808 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2846

    摘要： A once-a-day oral milnacipran pulsatile release composition has been developed that releases the drug in spaced apart “pulses”. The dosage forms are comprised of first, second and optional third dosage units, with each dosage unit having a different drug release profile. This dosage form provides in vivo drug plasma levels characterized by Cmax below 3000 ng/ml, preferably below 2000 ng/ml, and most preferably below 1000 ng/ml. The composition provides pulsatile release of milnacipran to produce a therapeutic effect over approximately 24 hours, when administered to a patient in need, resulting in diminished incidence or decreased intensity of common milnacipran side effects such as sleep disturbance, nausea, vomiting, headache, tremulousness, anxiety, panic attacks, palpitations, urinary retention, orthostatic hypotension, diaphoresis, chest pain, rash, weight gain, back pain, constipation, vertigo, increased sweating, agitation, hot flushes, tremors, fatigue, somnolence, dyspepsia, dysoria, nervousness, dry mouth, abdominal pain, irritability, and insomnia.

    摘要翻译： 已经开发了一种每天一次的口服米那普仑脉动释放组合物，其释放药物以间隔开的“脉冲”。 剂型由第一，第二和任选的第三剂量单位组成，每个剂量单位具有不同的药物释放曲线。 该剂型提供体内药物血浆水平，其特征在于低于3000ng / ml，优选低于2000ng / ml，最优选低于1000ng / ml的C max。 当给予需要的患者时，组合物提供米那普仑的脉动释放以产生约24小时的治疗效果，导致常见的米那普仑副作用的发生率降低或强度降低，例如睡眠障碍，恶心，呕吐，头痛，惊恐， 焦虑，惊恐发作，心悸，尿潴留，直立性低血压，透气，胸痛，皮疹，体重增加，背痛，便秘，眩晕，出汗增加，激动，潮红，震颤，疲劳，嗜睡，消化不良， 口干，腹痛，烦躁不安和失眠。

    Tire balancing
    8.
    发明授权
    Tire balancing 失效
    轮胎平衡

    公开(公告)号：US5766501A

    公开(公告)日：1998-06-16

    申请号：US251507

    申请日：1994-05-31

    申请人： Michael Heffernan ,  Russel J. Freeman

    发明人： Michael Heffernan ,  Russel J. Freeman

    IPC分类号： F16F15/36 ,  G01M1/36 ,  C09K3/00

    CPC分类号： G01M1/36 ,  B60C19/003 ,  F16F15/366 ,  G01M1/365

    摘要： A method and composition of matter for balancing tire and rim assemblies of vehicles is disclosed wherein the composition of matter has rounded balancing elements of different sizes to line the interior of a tire casing and to move over the lining to offset points of imbalance.

    摘要翻译： 公开了用于平衡车辆的轮胎和轮辋组件的物质的方法和组合物，其中物质的组成具有不同尺寸的圆形平衡元件以对着轮胎外壳的内部并且在衬里上移动到不平衡的偏移点。

    Technique for enabling a plurality of software components to communicate in a software component matrix environment
    10.
    发明授权
    Technique for enabling a plurality of software components to communicate in a software component matrix environment 有权
    用于使多个软件组件能够在软件组件矩阵环境中进行通信的技术

    公开(公告)号：US08086665B1

    公开(公告)日：2011-12-27

    申请号：US10224417

    申请日：2002-08-21

    申请人： Martin Soukup ,  Gregory Hughes ,  Michael Heffernan

    发明人： Martin Soukup ,  Gregory Hughes ,  Michael Heffernan

    IPC分类号： G06F15/16

    CPC分类号： H04L67/16 ,  G06F9/541 ,  G06F9/547 ,  H04L67/42

    摘要： A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.

    摘要翻译： 公开了一种使多个软件组件能够在软件组件矩阵环境中进行通信的技术。 在一个特定示例性实施例中，该技术可以通过使多个软件组件能够在软件组件矩阵环境中进行通信的方法来实现，该方法包括以下步骤：在客户端侧对请求进行编码; 通过通信接口将请求传送到服务器端的服务器; 将所述请求与在所述服务器侧支持的多个操作进行比较; 确定服务器端是否存在功能匹配; 以及响应于经由所述通信接口的所述请求，将包括所述功能匹配的响应返回给所述客户端，其中所述响应被映射到客户端的数据模型。