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公开(公告)号：US20110281279A1
公开(公告)日：2011-11-17
申请号：US12808470
申请日：2008-12-17
申请人： Peter Hamer , Stephen P. Bradley , Walter Carney
发明人： Peter Hamer , Stephen P. Bradley , Walter Carney
CPC分类号： G01N33/573 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57438 , G01N33/57488 , G01N2333/91215 , G01N2800/56
摘要： Provided are compositions, methods, and kits relating to the detection of a circulating or soluble form of the EphA2 receptor tyrosine kinase.
摘要翻译： 提供了与检测循环或可溶形式的EphA2受体酪氨酸激酶相关的组合物，方法和试剂盒。
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公开(公告)号：US20080288427A1
公开(公告)日：2008-11-20
申请号：US11949567
申请日：2007-12-03
IPC分类号： G06N3/08
摘要： A method of storing information relating to the transmission of messages by an entity over a given time period comprises the step of creating a signature comprising a plurality of parameters related to the transmission of messages over that time period wherein the parameters comprise at least one parameter related to the transmission of messages over a portion of the period and also related to the position of the portion in the period, to enable output data to be derived from the stored information. The signature may be updated by a weighted averaging process with other more recent signatures. Application in fraud detection where signature representing information in many call detail records from a particular subscriber is fed to a neural network.
摘要翻译： 存储与实体在给定时间段内的消息传输有关的信息的方法包括创建签名，该签名包括与该时间段上的消息传输相关的多个参数，其中参数包括至少一个参数 涉及在该周期的一部分上的消息的传输，并且还与该周期中该部分的位置有关，以使输出数据能够从存储的信息导出。 可以通过加权平均处理与其他更近的签名更新签名。 在欺诈检测中的应用，其中将来自特定用户的许多呼叫详细记录中的信息表示给神经网络。
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公开(公告)号：US07269185B2
公开(公告)日：2007-09-11
申请号：US09862861
申请日：2001-05-22
IPC分类号： H04J3/16 , H04J14/02 , G06F15/173 , G06F9/46
CPC分类号： H04L47/822 , H04L41/5022 , H04L41/5077 , H04L47/15 , H04L47/24 , H04L47/70 , H04L47/745 , H04L47/765 , H04L47/781 , H04L47/782 , H04L47/801 , H04L47/805 , H04L47/808 , H04L47/829
摘要： A communications network has multiple resource-allocation layers and incorporates a management structure for allocating resources to allocate resources requested by a first layer of said layers from a second of said layers. At a first layer, the management structure provides an indication to a second layer of the required resources that are to be allocated from the second layer. The second layer automatically offers the required resource together with a condition for use of those resources. This condition includes a notional price factor which is dependent on current demand. Under the control of the manager, the first layer determines if the condition for use of the offered resources is acceptable and, if so, automatically accepts the offered resources from the second layer. In a preferred embodiment, ingress to an underlying multi-wavelength transport layer of the network is controlled via a virtual port which allocates traffic to real ports one for each wavelength supported by the transport layer.
摘要翻译： 通信网络具有多个资源分配层，并且包括管理结构，用于分配资源以分配来自第二层的所述层的第一层所请求的资源。 在第一层，管理结构向第二层提供要从第二层分配的所需资源的指示。 第二层自动提供所需资源以及使用这些资源的条件。 这种情况包括依赖于当前需求的名义价格因素。 在管理者的控制下，第一层确定所提供资源的使用条件是否可以接受，如果是，则自动从第二层接受提供的资源。 在优选实施例中，通过虚拟端口来控制进入网络的底层多波长传输层，虚拟端口为传输层支持的每个波长分配一个流量到实际端口。
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公开(公告)号：US20070037224A1
公开(公告)日：2007-02-15
申请号：US11502013
申请日：2006-08-10
申请人： Peter Hamer , Walter Carney , Leticia Morris , James Elting
发明人： Peter Hamer , Walter Carney , Leticia Morris , James Elting
IPC分类号： G01N33/574 , G01N33/567
CPC分类号： G01N33/57488 , G01N33/57415 , G01N33/57419 , G01N33/57434 , G01N33/57449 , G01N33/57492 , G01N2333/49 , G01N2333/71 , G01N2800/52
摘要： The present invention is directed to the detection and quantification of total PDGFR-β in body fluids, particularly serial changes of total PDGFR-β levels in a subject's body fluids. Further, the invention is directed to detecting and quantitatiing total PDGFR-β in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for diseases, and useful to select therapies for patients with diseases, preferably preneoplastic/neoplastic diseases. The disclosed methods are particularly useful to monitor the status of a patient's disease, and/or to monitor how a patient is responding to a therapy.
摘要翻译： 本发明涉及体液中总PDGFR-β的检测和定量，特别是受试者体液中总PDGFR-β水平的连续变化。 此外，本发明涉及检测和定量总PDGFR-β与一种或多种其它蛋白质，例如癌蛋白，血管生成因子，肿瘤标志物，抑制剂，生长因子受体，转移蛋白和肿瘤抑制剂。 所公开的方法是疾病的诊断/预后，并且可用于选择具有疾病，优选肿瘤前/肿瘤性疾病的患者的治疗。 所公开的方法对于监测患者疾病的状态和/或监视患者如何对治疗作出反应特别有用。
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公开(公告)号：US6067535A
公开(公告)日：2000-05-23
申请号：US869884
申请日：1997-06-05
申请人： Phillip William Hobson , Peter Hamer , Kevin John Twitchen , Paul Colin Barson , Simon Field , Timothy John Edwards
发明人： Phillip William Hobson , Peter Hamer , Kevin John Twitchen , Paul Colin Barson , Simon Field , Timothy John Edwards
CPC分类号： H04W12/12 , G06N3/02 , G06Q20/403 , G06Q30/02 , G07F7/08
摘要： A method of managing the processing of information using a first neural network, the information relating to the transmission of messages in a telecommunications network, uses the steps of:(i) monitoring the performance of the first neural network in processing the information;(ii) creating a second neural network of the same topology as the first when a predetermined performance threshold is reached, and(iii) retraining the second neural network while continuing to process the information using the first neural network. If the neural networks are implemented using objects, such retraining can be facilitated by using a persistance mechanism to enable the objects to be stored and moved. Applications in fraud detection.
摘要翻译： 一种使用第一神经网络处理信息的方法，涉及电信网络中的消息传输的信息使用以下步骤：（i）在处理信息时监视第一神经网络的性能; （ii）当达到预定性能阈值时，创建与第一神经网络相同拓扑的第二神经网络，以及（iii）在继续使用第一神经网络处理信息的同时重新训练第二神经网络。 如果使用对象实现神经网络，则可以通过使用持续机制来使得能够存储和移动对象来促进这种再培训。 欺诈检测中的应用
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6.发明申请ASSAYS FOR CANCER PATIENT MONITORING BASED ON LEVELS OF ANALYTE COMPONENTS OF THE PLASMINOGEN ACTIVATOR SYSTEM IN BODY FLUID SAMPLES 失效基于体液活化剂体系中分子激活因子分析水平的癌症患者监测的测定公开(公告)号：US20080113392A1
公开(公告)日：2008-05-15
申请号：US11965323
申请日：2007-12-27
申请人： Walter Carney , Peter Hamer
发明人： Walter Carney , Peter Hamer
CPC分类号： G01N33/57484 , G01N33/86 , G01N2333/8132 , G01N2333/9723 , G01N2800/52 , Y10T436/25
摘要： The present invention describes clinically and medically important methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a method of monitoring the progression of disease, or the effectiveness of cancer treatment, in a cancer patient by measuring the levels of one or more analytes of the plasminogen activator (uPA) system, namely, uPA, PAI-1 and the complex of uPA:PAI-1, in a sample taken from the cancer patient, preferably, before treatment, at the start of treatment, and at various time intervals during treatment. As a result of performing the method, an increase or elevation in the levels of one or more of the PA system analytes in the cancer patient compared with the levels one or more of the respective PA system analytes in normal control individuals serves as an indicator of cancer advancement or progression and/or a lack of treatment effectiveness for the patient.
摘要翻译： 本发明描述临床和医学上重要的随时间的检查，筛选和监测正在接受治疗或治疗他或她的疾病的癌症患者的结果的重要方法。 更具体地，本发明提供了通过测量纤溶酶原激活物（uPA）系统的一种或多种分析物的水平，即uPA，PAI-1，在癌症患者中监测疾病进展或癌症治疗的有效性的方法， 1和来自癌症患者的样品中的uPA：PAI-1的复合物，优选在治疗前，治疗开始时和治疗期间的各个时间间隔。 作为执行该方法的结果，癌症患者中的一种或多种PA系统分析物的水平的增加或升高与正常对照个体中相应的PA系统分析物中的一个或多个水平相比作为 癌症进展或进展和/或患者缺乏治疗有效性。
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公开(公告)号：US07363371B2
公开(公告)日：2008-04-22
申请号：US09750903
申请日：2000-12-28
申请人： Paul Kirkby , Peter Hamer
发明人： Paul Kirkby , Peter Hamer
IPC分类号： G06F13/00
CPC分类号： H04L47/825 , H04L47/11 , H04L47/15 , H04L47/263 , H04L47/70 , H04L47/788 , H04L47/822
摘要： Admission of rapidly varying traffic flows to a communications network is controlled by sampling the traffic flows each at an ingress, and sampling an aggregate flow of said flows at some or all of the resources used by the aggregate flow. From this sampling, a mean bandwidth requirement for each traffic flow and a measure of the variance from that mean are determined. First and second prices for the mean and variance components of the controlled traffic flows that are calculated. These price calculations are used to determine an admission cost for each said flow so as to regulate the admission of that flow via a feedback price mechanism.
摘要翻译： 对通信网络的快速变化的业务流的接纳通过对每个入口处的业务流进行采样来控制，并且在集合流使用的部分或全部资源中对所述流的汇总流进行采样来控制。 从该采样中，确定每个业务流的平均带宽需求以及与该平均值的方差的度量。 计算的受控交通流量的均值和方差分量的第一和第二价格。 这些价格计算用于确定每个所述流程的入场费用，以便通过反馈价格机制来规范该流量的准入。
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公开(公告)号：US6038555A
公开(公告)日：2000-03-14
申请号：US872332
申请日：1997-06-10
CPC分类号： H04W12/12 , G06N3/02 , G06Q20/403 , G06Q30/02 , G07F7/08
摘要： A generic anomaly detection engine is described which provides neural network technology to process information such as call detail records and detect anomalies in the information, such as mobile phone fraud. Information from call detail records is pre-processed to form signatures which represent the calling behavior of a subscriber. These signatures are formed in one of a plurality of predetermined formats. The generic anomaly detection engine is instantiated in order to create an anomaly detector which is suitable for a particular situation and during the instantiation process the topology of the neural network components is automatically adjusted to fit the required situation. The topology is adjusted to according to the format of the signatures.
摘要翻译： 描述了一种通用异常检测引擎，其提供神经网络技术来处理诸如呼叫详细记录的信息，并且检测诸如移动电话欺诈的信息中的异常。 来自呼叫详细记录的信息被预先处理以形成表示用户呼叫行为的签名。 这些签名以多种预定格式之一形成。 通用异常检测引擎被实例化，以创建适合于特定情况的异常检测器，并且在实例化过程期间，神经网络部件的拓扑被自动调整以适应所需的情况。 拓扑根据签名的格式进行调整。
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公开(公告)号：US07161902B2
公开(公告)日：2007-01-09
申请号：US10156428
申请日：2002-05-28
申请人： Malcolm Carter , David Ireland , Kevin Warbrick , Jon Weil , Peter Hamer , Richard Clegg , Arthur Clune
发明人： Malcolm Carter , David Ireland , Kevin Warbrick , Jon Weil , Peter Hamer , Richard Clegg , Arthur Clune
IPC分类号： H04J1/16
CPC分类号： H04L47/10 , H04L45/00 , H04L45/566 , H04L45/60 , H04L47/11 , H04L47/12 , H04L47/22 , H04L47/24 , H04L47/25 , H04L47/41 , Y02D50/30
摘要： Congestion control in a communications network, e.g. an Internet Protocol (IP) network, is effected by controlling the egress rate of traffic from the output buffer of the system routers or switches. The traffic egressing from an output buffer is sampled at sequential intervals to determine a bit rate at each interval. An autocorrelation function is calculated from these samples and is used to provide an estimated statistical measure or parameter indicative of congestion and related to a long range dependence of the traffic. A calculation is then made as to whether an increase or a decrease in the buffer output rate would result in a decrease in the congestion parameter, and the buffer output rate is adjusted accordingly.
摘要翻译： 通信网络中的拥塞控制，例如 通过控制来自系统路由器或交换机的输出缓冲器的流量的出口速率来实现因特网协议（IP）网络。 从输出缓冲区流出的业务以连续的间隔进行采样，以确定每个间隔的比特率。 从这些样本计算自相关函数，并用于提供指示拥塞并与流量的长程依赖关系相关的估计统计量度或参数。 然后计算缓冲器输出速率的增加或减小是否会导致拥塞参数的减少，并且相应地调整缓冲器输出速率。
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公开(公告)号：US20100267058A1
公开(公告)日：2010-10-21
申请号：US12808708
申请日：2008-12-17
申请人： Peter Hamer , Stephen P. Bradley , Walter Carney
发明人： Peter Hamer , Stephen P. Bradley , Walter Carney
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： G01N33/566 , G01N33/57488 , G01N2333/91215
摘要： Provided are compositions, methods, and kits relating to the detection of a circulating or soluble form of the KET receptor tyrosine kinase.
摘要翻译： 提供了与检测循环或可溶形式的KET受体酪氨酸激酶相关的组合物，方法和试剂盒。
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