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公开(公告)号：US07270969B2
公开(公告)日：2007-09-18
申请号：US10372003
申请日：2003-02-21
CPC分类号： C12N15/1086 , C07K7/06 , C07K7/08 , C07K14/001 , C12N15/1034 , C40B30/04 , G01N33/569 , G01N33/574 , Y02A50/57 , Y02A50/58
摘要： The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the libraries are derived from two or more diverse characterized genomes.
摘要翻译： 本发明提供用于产生表达高度多样化肽或蛋白质结构域的核酸片段文库的新方法，特别是用于产生核酸片段文库的方法，其中文库的核酸片段衍生自两个或多个不同特征的基因组。
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2.发明授权Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom 有权构建生物多样性基因片段文库和从其分离的生物调节剂的方法公开(公告)号：US07803765B2
公开(公告)日：2010-09-28
申请号：US10546333
申请日：2004-02-20
CPC分类号： C07K7/08 , C07K7/06 , C07K14/001 , C12N15/1034 , C40B30/04 , G01N33/569 , G01N33/574 , Y02A50/57 , Y02A50/58
摘要： The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid.
摘要翻译： 本发明提供用于产生表达高度多样化的肽或蛋白质结构域的核酸片段文库的新方法，特别是用于产生其中核酸的核酸片段文库的方法。
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3.发明授权公开(公告)号：US06994982B1
公开(公告)日：2006-02-07
申请号：US09568229
申请日：2000-05-05
IPC分类号： G01N33/569
CPC分类号： C12N15/1086 , C07K7/06 , C07K7/08 , C07K14/001 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1058 , C40B30/04 , C40B40/08 , C40B40/10 , C40B50/06 , G01N33/569 , G01N33/574 , G01N33/6845 , Y02A50/57 , Y02A50/58
摘要： The present invention provides a method for identifying a modulator or mediator of a biological activity, which activity includes antigenicity and or immunogenicity, said method comprising the step of: (i) producing a gene fragment expression library derived from defined nucleotide sequence fragments; and (ii) assaying the expression library for at least an amino acid sequence derived from step (i) for a biological activity wherein that activity is different from any activity the amino acid sequence may have in its native environment.
摘要翻译： 本发明提供了鉴定生物活性的调节剂或介体的方法，该活性包括抗原性和/或免疫原性，所述方法包括步骤
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公开(公告)号：US20130104341A1
公开(公告)日：2013-05-02
申请号：US13663422
申请日：2012-10-29
IPC分类号： E05D3/02
CPC分类号： E05D3/02 , E05D5/16 , E05Y2201/632 , E05Y2800/422 , E05Y2900/132 , Y10T16/537
摘要： A door hinge assembly is provided. The door hinge assembly includes a first hinge plate, a second hinge plate, one or more bushings, a hinge pin and a hollow sleeve. The first and second hinge plate includes a one or more first and second knuckles aligned axially. At least one of the one or more bushings is positioned in between the first and second knuckle to prevent direct contact of first and second knuckle. The hinge pin is disposed through the first and second knuckles and one or more bushings. The hollow sleeve acts a covering to the hinge pin. The hollow sleeve further prevents contact of the sides of the first knuckle, bushings and second knuckle with the hinge pin. This prevents a direct metal on metal contact and further prevents squeak or other noises occurred during the opening and closing of the door.
摘要翻译： 提供了一个门铰链组件。 门铰链组件包括第一铰链板，第二铰链板，一个或多个衬套，铰链销和中空套筒。 第一和第二铰链板包括轴向对准的一个或多个第一和第二转向节。 所述一个或多个衬套中的至少一个位于第一和第二转向节之间，以防止第一和第二转向节的直接接触。 铰链销穿过第一和第二转向节以及一个或多个衬套。 中空的套管将一个覆盖物作用于铰链销。 中空套筒进一步防止了第一转向节，衬套和第二转向节的侧面与铰链销的接触。 这防止金属接触上的直接金属，并且进一步防止在门的打开和关闭期间发生吱吱声或其他噪声。
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5.发明授权
公开(公告)号：US6147201A
公开(公告)日：2000-11-14
申请号：US472123
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K39/00 , C07K14/435 , C07H21/04
CPC分类号： C07K14/43531 , A61K38/00 , A61K39/00
摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.
摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae过敏原的DNA，Der f I和Der f II以及编码D.pteronyssinus变应原的DNA，Der p I.另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。
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6.发明授权Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor 失效编码房屋尘螨过敏原的核酸，Der p VII，并用于此公开(公告)号：US06849427B1
公开(公告)日：2005-02-01
申请号：US08081540
申请日：1993-06-22
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： C12N15/09 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/395 , A61P37/08 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/725 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C12P21/08 , C12Q1/02 , G01N33/53 , G01N33/569 , G01N33/68 , C12N1/20
CPC分类号： C07K14/43531 , A61K38/00 , C07K14/7051 , C07K2319/00 , G01N33/56966 , G01N33/6893 , G01N2800/24 , Y10S530/868
摘要： A novel protein allergen Der p VII of Dermatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a λgt11 library of D. pteronyssinus cDNA. The nucleic acid sequence of Der p VII encodes a 198 residue mature processed protein having a predicted molecular weight of 22,177 daltons. Der p VII protein may be used as the active ingredient in therapeutic composition for the treatment of sensitivity to house dust mites. The protein may also be used in methods of diagnosing such sensitivity.
摘要翻译： 描述了Dermatophagoides pteronyssinus的新型蛋白质过敏原Der VII。 从D.pteronyssinus cDNA的lambdagt11文库中分离编码Der p VII的cDNA克隆。 Der p VII的核酸序列编码具有预测分子量为22,177道尔顿的198残基成熟加工蛋白。 Der p VII蛋白可用作治疗组合物中用于治疗房尘螨敏感性的活性成分。 该蛋白质也可用于诊断这种敏感性的方法。
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公开(公告)号：US06689876B1
公开(公告)日：2004-02-10
申请号：US08175071
申请日：1993-12-29
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： C07H2104
CPC分类号： C07K14/43531 , A61K38/00 , C07K14/5403
摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronyssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.
摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae过敏原的DNA，Der f I和Der f II以及编码D.pteronyssinus变应原的DNA，Der p I.另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。
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公开(公告)号：US10316559B2
公开(公告)日：2019-06-11
申请号：US13663422
申请日：2012-10-29
摘要： A door hinge assembly is provided. The door hinge assembly includes a first hinge plate, a second hinge plate, one or more bushings, a hinge pin and a hollow sleeve. The first and second hinge plate includes a one or more first and second knuckles aligned axially. At least one of the one or more bushings is positioned in between the first and second knuckle to prevent direct contact of first and second knuckle. The hinge pin is disposed through the first and second knuckles and one or more bushings. The hollow sleeve acts a covering to the hinge pin. The hollow sleeve further prevents contact of the sides of the first knuckle, bushings and second knuckle with the hinge pin. This prevents a direct metal on metal contact and further prevents squeak or other noises occurred during the opening and closing of the door.
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9.发明授权
公开(公告)号：US06086897A
公开(公告)日：2000-07-11
申请号：US465093
申请日：1995-06-05
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： A61K39/35 , A61K38/00 , A61K39/36 , A61K49/00 , A61P37/08 , C07H21/04 , C07K14/00 , C07K14/435 , C07K14/54 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/53 , G01N33/569
CPC分类号： C07K14/43531 , C07K14/5403 , A61K38/00
摘要： Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, DNA encoding two major D. farinae allergens, Der f I and Der f II and DNA encoding a D. pteronssinus allergen, Der p I. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens.
摘要翻译： 编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是蛋白质过敏原或包括蛋白质变应原的至少一个表位的肽。 特别地，编码两个主要的D. farinae变应原的Der DNA和Der f II以及编码D.pteronssinus变应原Der P的DNA。另外，由分离的DNA编码的蛋白质或肽，它们用作诊断和 诊断和治疗房屋尘螨过敏原敏感性的治疗试剂和方法。
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公开(公告)号：US6077517A
公开(公告)日：2000-06-20
申请号：US462778
申请日：1995-06-05
申请人： Wayne Robert Thomas , Kaw-Yan Chua
发明人： Wayne Robert Thomas , Kaw-Yan Chua
IPC分类号： C12N15/09 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/395 , A61P37/08 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/725 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C12P21/08 , C12Q1/02 , G01N33/53 , G01N33/569 , G01N33/68 , C07K1/00
CPC分类号： C07K14/43531 , C07K14/7051 , G01N33/56966 , G01N33/6893 , A61K38/00 , C07K2319/00 , G01N2800/24 , Y10S530/868
摘要： A novel protein allergen Der p VII of Dennatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a .lambda.gt11 library of D. pteronyssinus cDNA. The nucleic acid sequence of der p VII encodes a 198 residue mature processed protein having a predicted molecular weight of 22,177 daltons. Der p VII protein may be used as the active ingredient in therapeutic composition for the treatment of sensitivity to house dust mites. The protein may also be used in methods of diagnosing such sensitivity.
摘要翻译： 描述了Dennatophagoides pteronyssinus的新型蛋白质过敏原Der VII。 从D.pteronyssinus cDNA的λgt11文库中分离编码Der p VII的cDNA克隆。 衍生物VII的核酸序列编码具有预测分子量为22,177道尔顿的198残基成熟加工蛋白质。 Der p VII蛋白可用作治疗组合物中用于治疗房尘螨敏感性的活性成分。 该蛋白质也可用于诊断这种敏感性的方法。
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