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公开(公告)号:US5698733A
公开(公告)日:1997-12-16
申请号:US480707
申请日:1995-06-07
IPC分类号: A61K31/557 , A61K31/5575 , A61P9/12 , C07C405/00 , C07C69/76
CPC分类号: A61K31/5575 , C07C405/00 , C07C405/0016
摘要: Disclosed are 9-deoxyprostaglandins which are useful in the treatment of glaucoma and ocular hypertension. Some of these 9-deoxyprostaglandins are novel. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
摘要翻译: 公开了可用于治疗青光眼和高眼压症的9-脱氧前列腺素。 这些9-脱氧前列腺素中的一些是新颖的。 还公开了包含这种前列腺素的眼科药物组合物。
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2.
公开(公告)号:US06169111A
公开(公告)日:2001-01-02
申请号:US09308052
申请日:1999-05-12
IPC分类号: A61K31557
CPC分类号: C07C405/0016 , A61K31/557 , A61K31/5575 , C07C405/00
摘要: Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic pharmaceutical compositions comprising said prostaglandins.
摘要翻译: 构形刚性的前列腺素可用于治疗青光眼和高眼压症。 还公开了包含所述前列腺素的眼用药物组合物。
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3.Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension 失效
标题翻译: 使用某些前列腺素类似物治疗青光眼和高眼压症公开(公告)号:US5807892A
公开(公告)日:1998-09-15
申请号:US480706
申请日:1995-06-07
IPC分类号: A61K31/557 , A61K31/5575 , C07C405/00 , A61K31/695 , A61K31/35 , C07C177/00
CPC分类号: A61K31/5575 , A61K31/557 , C07C405/0016
摘要: Certain prostaglandin analogues are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandin analogues.
摘要翻译: 某些前列腺素类似物可用于治疗青光眼和高眼压症。 还公开了包含这种前列腺素类似物的眼科药物组合物。
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公开(公告)号:US06680339B2
公开(公告)日:2004-01-20
申请号:US10100399
申请日:2002-03-18
申请人: Peter G. Klimko , Mark R. Hellberg , Paul W. Zinke
发明人: Peter G. Klimko , Mark R. Hellberg , Paul W. Zinke
IPC分类号: A61K31216
CPC分类号: C07C405/00 , A61K31/5575
摘要: 15-fluoro substituted analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
摘要翻译: 公开了PGF2α的15-氟取代类似物及其用于治疗青光眼和高眼压症的方法。
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公开(公告)号:US06197812B1
公开(公告)日:2001-03-06
申请号:US09440248
申请日:1999-11-15
IPC分类号: A61K31341
CPC分类号: C07D307/18 , A61K31/5585 , C07D307/20 , C07D493/04
摘要: Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
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公开(公告)号:US06172109B2
公开(公告)日:2001-01-09
申请号:US09077507
申请日:1998-06-03
申请人: Paul W. Zinke , Mark R. Hellberg
发明人: Paul W. Zinke , Mark R. Hellberg
IPC分类号: A61K315575
CPC分类号: C07C405/0033
摘要: 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.
摘要翻译: 13-thia前列腺素可用于治疗青光眼和高眼压症。 还公开了包含所述前列腺素的眼科药物组合物。
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7.substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives 失效
标题翻译: 前列腺素的取代四氢呋喃类似物作为眼睛低血压公开(公告)号:US6025392A
公开(公告)日:2000-02-15
申请号:US109852
申请日:1998-07-02
IPC分类号: C07D307/12 , A61K31/34 , A61K31/341 , A61K31/557 , A61K31/5585 , A61P27/02 , A61P27/06 , A61P43/00 , C07D307/02 , C07D307/14 , C07D307/18 , C07D307/20 , C07D407/06 , C07D493/04
CPC分类号: C07D307/18 , A61K31/5585 , C07D307/20 , C07D493/04
摘要: Substituted tetrahydrofuran analogs of F-series prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.
摘要翻译: 公开了F系列前列腺素的取代四氢呋喃类似物及其用于治疗青光眼和高眼压症的方法。
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公开(公告)号:US06649653B1
公开(公告)日:2003-11-18
申请号:US09284432
申请日:1999-06-02
申请人: Peter G. Klimko , Mark R. Hellberg , Paul W. Zinke
发明人: Peter G. Klimko , Mark R. Hellberg , Paul W. Zinke
IPC分类号: A61K31216
CPC分类号: A61K31/5575 , C07C405/00
摘要: 15-Fluoro substituted analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
摘要翻译: 公开了PGF2α的15-氟取代类似物及其用于治疗青光眼和高眼压症的方法。
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9.11-halo prostaglandins for the treatment of glaucoma or ocular hypertension 失效
标题翻译: 用于治疗青光眼或高眼压症的11-halo前列腺素公开(公告)号:US06353000B1
公开(公告)日:2002-03-05
申请号:US09284533
申请日:1999-06-02
IPC分类号: A01N4316
CPC分类号: C07C405/0016 , A61K31/5575 , C07C405/00
摘要: A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I:
摘要翻译: 一种治疗患者的青光眼或高眼压症的方法,其包括向患者施用药学有效量的式I化合物:
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10.COMPOUNDS WITH 5-HT1A ACTIVITY USEFUL FOR TREATING DISORDERS OF THE OUTER RETINA 审中-公开
标题翻译: 具有5-HT1A活性的化合物可用于治疗外周疾病公开(公告)号:US20100168121A1
公开(公告)日:2010-07-01
申请号:US12719152
申请日:2010-03-08
IPC分类号: A61K31/506 , A61K31/496 , A61K31/428 , A61K31/4418 , A61K31/438 , A61K31/4433 , A61K31/135 , A61P27/02
CPC分类号: A61K31/519 , A61K31/496 , A61K31/506 , Y10S514/912
摘要: Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
摘要翻译: 公开了用具有5-HT1A激动剂活性的化合物治疗外部视网膜疾病的组合物和方法。
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