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公开(公告)号：US20080085242A1
公开(公告)日：2008-04-10
申请号：US11848399
申请日：2007-08-31
IPC分类号： A61K31/7088 , A61K49/00 , A61P31/00 , A61P35/00
CPC分类号： A61K9/08 , A61K9/0073 , A61K47/61 , A61K48/0041 , C12N15/87
摘要： The present invention concerns a novel composition comprising a nucleic acid; and a chitosan containing branching groups covalently linked to the amino groups wherein said branches are selected from the following groups; alkyl with 2 or more carbon atoms, monosaccharides, oligosaccharides or polysaccharides. The composition is particularly useful as a non-viral gene delivery system. The composition facilitates the introduction of the nucleic acid into the cells to which it is administrated, as well as the expression of the function of the nucleic acid.
摘要翻译： 本发明涉及包含核酸的新型组合物; 和含有与氨基共价连接的支链基团的壳聚糖，其中所述分支选自以下基团; 具有2个或更多碳原子的烷基，单糖，寡糖或多糖。 该组合物特别可用作非病毒基因递送系统。 该组合物促进将核酸引入其所施用的细胞中，以及核酸的功能的表达。
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公开(公告)号：US20050164964A1
公开(公告)日：2005-07-28
申请号：US10513311
申请日：2003-05-02
IPC分类号： G01N33/50 , A61K9/08 , A61K31/7088 , A61K47/36 , A61K47/48 , A61K48/00 , A61P7/00 , A61P31/00 , A61P37/06 , A61P43/00 , C12N15/09 , C12N15/87 , C12Q1/68 , C07H21/04 , C08B37/08
CPC分类号： A61K9/08 , A61K9/0073 , A61K47/61 , A61K48/0041 , C12N15/87
摘要： The present invention concerns a novel composition comprising a nucleic acid; and a chitosan containing branching groups covalently linked to the amino groups wherein said branches are selected from the following groups; alkyl with 2 or more carbon atoms, monosaccharides, oligosaccharides or polysaccharides. The composition is particularly useful as a non-viral gene delivery system. The composition facilitates the introduction of the nucleic acid into the cells to which it is administrated, as well as the expression of the function of the nucleic acid.
摘要翻译： 本发明涉及包含核酸的新型组合物; 和含有与氨基共价连接的支链基团的壳聚糖，其中所述分支选自以下基团; 具有2个或更多碳原子的烷基，单糖，寡糖或多糖。 该组合物特别可用作非病毒基因递送系统。 该组合物促进将核酸引入其所施用的细胞中，以及核酸的功能的表达。
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公开(公告)号：US20070298048A1
公开(公告)日：2007-12-27
申请号：US11809816
申请日：2007-06-01
CPC分类号： C12N15/87 , A61K9/0073 , A61K47/61 , A61K48/0041
摘要： The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP) 50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.
摘要翻译： 本发明涉及一种组合物，其包含衍生自阳离子多糖壳聚糖的阳离子壳聚糖低聚物的复合物，其中所述阳离子低聚物除了重量分数外还含有小于20％聚合度（DP）<10的低聚物的重量分数 小于20％，DP> 50，和核酸。 包含具有一定分子量链长度的定义明确的阳离子壳聚糖低聚物的这些组合物和核酸有利于实现将核酸递送至选定组织的细胞中，并获得由所述组合编码的所需分子的体内表达 核酸。
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公开(公告)号：US20050170355A1
公开(公告)日：2005-08-04
申请号：US10513429
申请日：2003-05-02
IPC分类号： A61K47/36 , A61K31/7088 , A61K39/00 , A61K47/46 , A61K47/48 , A61K48/00 , A61P31/00 , A61P35/00 , A61P37/06 , C12N15/87 , C12Q1/68 , C07H21/02 , C08B37/08
CPC分类号： C12N15/87 , A61K9/0073 , A61K47/61 , A61K48/0041
摘要： The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP) 50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.
摘要翻译： 本发明涉及一种组合物，其包含衍生自阳离子多糖壳聚糖的阳离子壳聚糖低聚物的复合物，其中所述阳离子低聚物除了重量分数外还含有小于20％聚合度（DP）<10的低聚物的重量分数 小于20％，DP> 50，和核酸。 包含具有一定分子量链长度的定义明确的阳离子壳聚糖低聚物的这些组合物和核酸有利于实现将核酸递送至选定组织的细胞中，并获得所编码的所需分子的体内表达 核酸。
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公开(公告)号：US20070036864A1
公开(公告)日：2007-02-15
申请号：US10577306
申请日：2004-10-27
IPC分类号： A61K9/14
摘要： An oral hygiene product, such as tooth paste, is described. A methos for controlling undesirable bacterial flora in the oral cavity, as well as the use of the plant Sphagnum, are also described.
摘要翻译： 描述了诸如牙膏的口腔卫生产品。 还描述了用于控制口腔中不期望的细菌菌群的方法以及植物Sphagnum的使用。
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公开(公告)号：US20050153397A1
公开(公告)日：2005-07-14
申请号：US10973973
申请日：2004-10-26
IPC分类号： C12N9/00 , C12N9/10 , C12N9/20 , C12N9/24 , C12N15/80 , C12P21/02 , C12N1/16 , C12N9/08 , C12N15/74
CPC分类号： C12N9/1085 , C12N9/00 , C12N9/10 , C12N9/20 , C12N9/248 , C12N9/2482 , C12N9/88 , C12N15/80 , C12P21/02 , C12R1/69 , C12Y302/01008
摘要： The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes responsible for the biosynthesis or secretion of at least one toxin, and (ii) the mutant produces less of the toxin than the parent Aspergillus cell when cultured under the same conditions; and (b) isolating the polypeptide from the culture medium. Also, mutants of Aspergillus cells are provided, as well as methods for obtaining the mutant cells.
摘要翻译： 本发明涉及通过（a）培养母体曲霉细胞的突变体来产生感兴趣多肽的方法，其中（i）突变体包含编码多肽的第一核酸序列和包含修饰的第二核酸序列 负责至少一种毒素的生物合成或分泌的基因中的至少一个，和（ii）当在相同条件下培养时，突变体产生比母体曲霉细胞少的毒素; 和（b）从培养基中分离多肽。 此外，提供了曲霉菌细胞的突变体，以及获得突变细胞的方法。
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7.发明申请Apparatus and method for dependency tracking and register file bypass controls using a scannable register file 审中-公开使用可扫描寄存器文件的依赖关系跟踪和寄存器文件旁路控制的装置和方法公开(公告)号：US20060168393A1
公开(公告)日：2006-07-27
申请号：US11044567
申请日：2005-01-27
申请人： Bjorn Christensen , Peter Klim , Dung Nguyen , Raymond Yeung
发明人： Bjorn Christensen , Peter Klim , Dung Nguyen , Raymond Yeung
IPC分类号： G06F12/14
CPC分类号： G06F9/30141 , G06F9/30134 , G06F9/3828 , G06F9/3838 , G06F9/3867
摘要： An apparatus and method for dependency tracking and register file bypass controls using a scannable register file are provided. With the apparatus and method, a scannable register file array is provided and used to track the stage of any instruction in the execution unit. Every entry in the target vector is updated every cycle to stay synchronized with the instructions in the execution unit. To keep the register file array synchronized with the instructions in the execution unit, a right shift of all the data in each entry of the register file array occurs every cycle. The scan port of the register file array cells is used as the shift function.
摘要翻译： 提供了使用可扫描寄存器文件的依赖关系跟踪和寄存器文件旁路控制的装置和方法。 利用该装置和方法，提供可扫描的寄存器文件阵列并用于跟踪执行单元中任何指令的阶段。 每个周期更新目标向量中的每个条目，以与执行单元中的指令保持同步。 为了使寄存器文件阵列与执行单元中的指令保持同步，每个周期都会发生寄存器文件阵列的每个条目中所有数据的右移。 寄存器文件阵列单元的扫描端口用作移位功能。
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8.发明授权Volume measurement and/or metering device and method for operating a volume measurement and/or metering device 有权用于操作体积测量和/或计量装置的体积测量和/或计量装置和方法公开(公告)号：US07753238B2
公开(公告)日：2010-07-13
申请号：US11674460
申请日：2007-02-13
IPC分类号： B67D7/58
CPC分类号： G01F11/028
摘要： A volume measurement and/or metering device includes a cylinder/piston and cock system for sucking in and/or discharging liquids in a defined way, the piston being movable in relation to the cylinder for sucking in or discharging the liquid. The cylinder is mounted, together with the cylinder bottom, rotatably with respect to the cock system about an axis of rotation parallel to the cylinder longitudinal axis. The cylinder bottom bears with a sealing seat against a cock element of the cock system, the cock element having at least one duct orifice. These orifices are arranged in such a way that the at least one orifice in the cylinder bottom can be brought into congruence with the orifices of the cock element when the cylinder and the cylinder bottom are rotated. Further, the cock element is brought into a sealing closing position for simultaneously closing of all the orifices of the cylinder bottom are provided.
摘要翻译： 容积测量和/或计量装置包括用于以限定的方式吸入和/或排出液体的气缸/活塞和旋塞系统，活塞可相对于气缸移动以吸入或排出液体。 气缸与气缸底部一起相对于旋塞系统围绕平行于气缸纵向轴线的旋转轴线可旋转地安装。 气缸底部具有抵靠旋塞系统的旋塞元件的密封座，所述旋塞元件具有至少一个管道孔口。 这些孔被布置成使得当气缸和气缸底部旋转时，气缸底部中的至少一个孔口可以与旋塞元件的孔口一致。 此外，提供旋塞元件进入密封关闭位置，以同时关闭气缸底部的所有孔。
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9.发明申请Volume Measurement and/or Metering Device and Method for Operating a Volume Measurement and/or Metering Device 有权用于操作体积测量和/或计量装置的体积测量和/或计量装置和方法公开(公告)号：US20070194055A1
公开(公告)日：2007-08-23
申请号：US11674460
申请日：2007-02-13
CPC分类号： G01F11/028
摘要： A volume measurement and/or metering device includes a cylinder/piston and cock system for sucking in and/or discharging liquids in a defined way, the piston being movable in relation to the cylinder for sucking in or discharging the liquid. The cylinder is mounted, together with the cylinder bottom, rotatably with respect to the cock system about an axis of rotation parallel to the cylinder longitudinal axis. The cylinder bottom bears with a sealing seat against a cock element of the cock system, the cock element having at least one duct orifice. These orifices are arranged in such a way that the at least one orifice in the cylinder bottom can be brought into congruence with the orifices of the cock element when the cylinder and the cylinder bottom are rotated. Further, means for simultaneously closing of all the orifices of the cylinder bottom are provided.
摘要翻译： 容积测量和/或计量装置包括用于以限定的方式吸入和/或排出液体的气缸/活塞和旋塞系统，活塞可相对于气缸移动以吸入或排出液体。 气缸与气缸底部一起相对于旋塞系统围绕平行于气缸纵向轴线的旋转轴线可旋转地安装。 气缸底部具有抵靠旋塞系统的旋塞元件的密封座，所述旋塞元件具有至少一个管道孔口。 这些孔被布置成使得当气缸和气缸底部旋转时，气缸底部中的至少一个孔口可以与旋塞元件的孔口一致。 此外，提供了用于同时关闭气缸底部的所有孔的装置。
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公开(公告)号：USD517957S1
公开(公告)日：2006-03-28
申请号：US29221914
申请日：2005-01-21
申请人： Frank Savage , Willie G. Davidson , Louis Netz , Kirk Rasmussen , Mike Alstrin , John Myers , Joe Dennert , Doug Reichardt , Chris Fecke , Brian Scherbarth , Joshua Hedtke , Jeff Spraggon , Phil Rusch , Ben Wright , Pierluigi Belloli , Bjorn Christensen , Tom Berry , Mark DeMilio , Suzanne J. Schneider , Carminati Fabiano , Mozzati Alberto , Cereda Marco , Carlos Sena
设计人： Frank Savage , Willie G. Davidson , Louis Netz , Kirk Rasmussen , Mike Alstrin , John Myers , Joe Dennert , Doug Reichardt , Chris Fecke , Brian Scherbarth , Joshua Hedtke , Jeff Spraggon , Phil Rusch , Ben Wright , Pierluigi Belloli , Bjorn Christensen , Tom Berry , Mark DeMilio , Suzanne J. Schneider , Carminati Fabiano , Mozzati Alberto , Cereda Marco , Carlos Sena
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