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公开(公告)号：US07767456B2
公开(公告)日：2010-08-03
申请号：US11809816
申请日：2007-06-01
CPC分类号： C12N15/87 , A61K9/0073 , A61K47/61 , A61K48/0041
摘要： The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP) 50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.
摘要翻译： 本发明涉及一种组合物，其包含衍生自阳离子多糖壳聚糖的阳离子壳聚糖低聚物的复合物，其中所述阳离子低聚物除了重量分数外还含有小于20％聚合度（DP）<10的低聚物的重量分数 小于20％，DP> 50，和核酸。 包含具有一定分子量链长度的定义明确的阳离子壳聚糖低聚物的这些组合物和核酸有利于实现将核酸递送至选定组织的细胞中，并获得所编码的所需分子的体内表达 核酸。
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公开(公告)号：US20070298048A1
公开(公告)日：2007-12-27
申请号：US11809816
申请日：2007-06-01
CPC分类号： C12N15/87 , A61K9/0073 , A61K47/61 , A61K48/0041
摘要： The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP) 50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.
摘要翻译： 本发明涉及一种组合物，其包含衍生自阳离子多糖壳聚糖的阳离子壳聚糖低聚物的复合物，其中所述阳离子低聚物除了重量分数外还含有小于20％聚合度（DP）<10的低聚物的重量分数 小于20％，DP> 50，和核酸。 包含具有一定分子量链长度的定义明确的阳离子壳聚糖低聚物的这些组合物和核酸有利于实现将核酸递送至选定组织的细胞中，并获得由所述组合编码的所需分子的体内表达 核酸。
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公开(公告)号：US20080085242A1
公开(公告)日：2008-04-10
申请号：US11848399
申请日：2007-08-31
IPC分类号： A61K31/7088 , A61K49/00 , A61P31/00 , A61P35/00
CPC分类号： A61K9/08 , A61K9/0073 , A61K47/61 , A61K48/0041 , C12N15/87
摘要： The present invention concerns a novel composition comprising a nucleic acid; and a chitosan containing branching groups covalently linked to the amino groups wherein said branches are selected from the following groups; alkyl with 2 or more carbon atoms, monosaccharides, oligosaccharides or polysaccharides. The composition is particularly useful as a non-viral gene delivery system. The composition facilitates the introduction of the nucleic acid into the cells to which it is administrated, as well as the expression of the function of the nucleic acid.
摘要翻译： 本发明涉及包含核酸的新型组合物; 和含有与氨基共价连接的支链基团的壳聚糖，其中所述分支选自以下基团; 具有2个或更多碳原子的烷基，单糖，寡糖或多糖。 该组合物特别可用作非病毒基因递送系统。 该组合物促进将核酸引入其所施用的细胞中，以及核酸的功能的表达。
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公开(公告)号：US20050164964A1
公开(公告)日：2005-07-28
申请号：US10513311
申请日：2003-05-02
IPC分类号： G01N33/50 , A61K9/08 , A61K31/7088 , A61K47/36 , A61K47/48 , A61K48/00 , A61P7/00 , A61P31/00 , A61P37/06 , A61P43/00 , C12N15/09 , C12N15/87 , C12Q1/68 , C07H21/04 , C08B37/08
CPC分类号： A61K9/08 , A61K9/0073 , A61K47/61 , A61K48/0041 , C12N15/87
摘要： The present invention concerns a novel composition comprising a nucleic acid; and a chitosan containing branching groups covalently linked to the amino groups wherein said branches are selected from the following groups; alkyl with 2 or more carbon atoms, monosaccharides, oligosaccharides or polysaccharides. The composition is particularly useful as a non-viral gene delivery system. The composition facilitates the introduction of the nucleic acid into the cells to which it is administrated, as well as the expression of the function of the nucleic acid.
摘要翻译： 本发明涉及包含核酸的新型组合物; 和含有与氨基共价连接的支链基团的壳聚糖，其中所述分支选自以下基团; 具有2个或更多碳原子的烷基，单糖，寡糖或多糖。 该组合物特别可用作非病毒基因递送系统。 该组合物促进将核酸引入其所施用的细胞中，以及核酸的功能的表达。
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公开(公告)号：US20050170355A1
公开(公告)日：2005-08-04
申请号：US10513429
申请日：2003-05-02
IPC分类号： A61K47/36 , A61K31/7088 , A61K39/00 , A61K47/46 , A61K47/48 , A61K48/00 , A61P31/00 , A61P35/00 , A61P37/06 , C12N15/87 , C12Q1/68 , C07H21/02 , C08B37/08
CPC分类号： C12N15/87 , A61K9/0073 , A61K47/61 , A61K48/0041
摘要： The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP) 50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.
摘要翻译： 本发明涉及一种组合物，其包含衍生自阳离子多糖壳聚糖的阳离子壳聚糖低聚物的复合物，其中所述阳离子低聚物除了重量分数外还含有小于20％聚合度（DP）<10的低聚物的重量分数 小于20％，DP> 50，和核酸。 包含具有一定分子量链长度的定义明确的阳离子壳聚糖低聚物的这些组合物和核酸有利于实现将核酸递送至选定组织的细胞中，并获得所编码的所需分子的体内表达 核酸。
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