公开(公告)号：US20050260153A1

公开(公告)日：2005-11-24

申请号：US11104812

申请日：2005-04-13

申请人： Pericles Calias ,  Gary Cook ,  David Shima ,  David Turner ,  Mary Ganley

发明人： Pericles Calias ,  Gary Cook ,  David Shima ,  David Turner ,  Mary Ganley

IPC分类号： A61K31/716 ,  A61K31/785 ,  A61K47/48 ,  A61K49/00 ,  C08G63/48 ,  C12Q1/68

CPC分类号： A61K49/0002 ,  A61K47/60 ,  A61K47/61

摘要： The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size.

摘要翻译： 本发明提供了制备和使用空间增强的拮抗剂适体缀合物的组合物和方法，其包括对靶分子具有特异性亲和力的核酸序列和增加或促进抑制结合或相互作用的可溶性高分子量空间基团 当靶分子与适配体缀合物结合时，靶分子结合配偶体。 本发明还提供了通过将带电部分附着到生物活性分子并通过离子电渗递送生物活性分子来生物活性分子的眼部递送的方法和制剂。 通过与具有相当大小的带电分子取代高分子量中性部分来增强与高分子量中性部分缀合的生物活性分子的离子电渗疗法。

公开(公告)号：US20050260651A1

公开(公告)日：2005-11-24

申请号：US11105279

申请日：2005-04-13

申请人： Pericles Calias ,  Gary Cook ,  David Shima ,  Anthony Adamis ,  Yin-Shan Ng ,  Gregory Robinson ,  David Turner ,  Mary Ganley

发明人： Pericles Calias ,  Gary Cook ,  David Shima ,  Anthony Adamis ,  Yin-Shan Ng ,  Gregory Robinson ,  David Turner ,  Mary Ganley

IPC分类号： A61K31/716 ,  A61K31/785 ,  A61K47/48 ,  A61K49/00 ,  C08G63/48 ,  C12Q1/68

CPC分类号： A61K49/0002 ,  A61K47/60 ,  A61K47/61

摘要： The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size.

摘要翻译： 本发明提供了制备和使用空间增强的拮抗剂适体缀合物的组合物和方法，其包括对靶分子具有特异性亲和力的核酸序列和增加或促进抑制结合或相互作用的可溶性高分子量空间基团 当靶分子与适配体缀合物结合时，靶分子结合配偶体。 本发明还提供了通过将带电部分附着到生物活性分子并通过离子电渗递送生物活性分子来生物活性分子的眼部递送的方法和制剂。 通过与具有相当大小的带电分子取代高分子量中性部分来增强与高分子量中性部分缀合的生物活性分子的离子电渗疗法。

公开(公告)号：US20070292475A1

公开(公告)日：2007-12-20

申请号：US11607382

申请日：2006-12-01

申请人： Kathleen Campbell ,  Pericles Calias ,  Gary Cook ,  Mary Ganley

发明人： Kathleen Campbell ,  Pericles Calias ,  Gary Cook ,  Mary Ganley

IPC分类号： A61K9/52 ,  A61P27/02

CPC分类号： A61K38/1866 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/1647 ,  A61K31/00

摘要： Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.

摘要翻译： 已经开发了用于治疗眼部疾病的生物活性剂的受控持续释放的制剂。 这些制剂基于由可生物降解的合成聚合物如聚（乳酸）（PLA），聚（乙醇酸）（PGA）及其共聚物的组合形成的固体微粒。 微粒的特征在于低爆发水平和有效的药物负载和持续释放。

公开(公告)号：US08478116B2

公开(公告)日：2013-07-02

申请号：US12542834

申请日：2009-08-18

申请人： Sam W. Henry ,  Paul Neilson ,  Gary Cook

发明人： Sam W. Henry ,  Paul Neilson ,  Gary Cook

IPC分类号： F24H1/20

CPC分类号： H05B3/82 ,  B65D88/744 ,  H05B3/42

摘要： Disclosed is a heating unit which can comprise a tube, or pipe, having an aperture therein which can be configured to receive a heating element. In various embodiments, the heating element can comprise a resistive element which can be configured to generate heat when a voltage differential is applied thereto. In certain embodiments, the heating unit can further comprise a collar which is threadably engaged with the tube, wherein a flame path, or exhaust path, can be defined between threads on the pipe and threads on the collar, for example. In certain embodiments, the flame path can comprise a passageway defined between the circumference, or perimeter, of the tube and the collar. Such a flame path can be configured to allow pressurized gasses to safely escape from the tube along a predetermined path.

摘要翻译： 公开了一种加热单元，其可以包括管或管，其中具有孔，其可以构造成接收加热元件。 在各种实施例中，加热元件可以包括电阻元件，电阻元件可被配置为当施加电压差而产生热量。 在某些实施例中，加热单元还可以包括与管螺纹接合的套环，其中例如可以在管上的螺纹和套环上的螺纹之间限定火焰通道或排气路径。 在某些实施例中，火焰通道可以包括限定在管和套环的圆周或周边之间的通道。 这样的火焰通道可以被配置成允许加压气体沿预定路径从管中安全地逸出。

公开(公告)号：US20120267353A1

公开(公告)日：2012-10-25

申请号：US13540345

申请日：2012-07-02

申请人： Robert Eveleigh ,  Gary Cook

发明人： Robert Eveleigh ,  Gary Cook

IPC分类号： H05B3/00 ,  F16K11/22 ,  F28F9/00

CPC分类号： A61H33/60 ,  A47K3/286 ,  A61H33/0095 ,  A61H35/02 ,  E03C1/0408 ,  G05D23/1393 ,  Y10T137/87684

摘要： The present invention is directed to methods and apparatus for tempering the temperature of a liquid in a fluid conducting system. More particularly, the invention relates to tempering the temperature of water supplied to a fixture from a water heater in a fluid conducting system. In some embodiments, the invention includes a restrictor for decreasing the fluid pressure in one of the hot inlet or cold inlet of the mixing valve.

摘要翻译： 本发明涉及用于回火流体传导系统中的液体的温度的方法和装置。 更具体地，本发明涉及回流从流体传导系统中的热水器供应到固定装置的水的温度。 在一些实施例中，本发明包括用于降低混合阀的热入口或冷入口之一中的流体压力的限制器。

公开(公告)号：US08145019B1

公开(公告)日：2012-03-27

申请号：US12483880

申请日：2009-06-12

申请人： Gary Cook ,  Dean R. Evans

发明人： Gary Cook ,  Dean R. Evans

IPC分类号： G02B6/34

CPC分类号： G02B6/12007 ,  G01N21/774 ,  G02B6/02128 ,  G02B6/02133 ,  G02B6/124

摘要： The present invention provides a method for adjusting a diffraction grating to changes in ambient conditions. The method includes writing a diffraction grating in the photorefractive waveguide with a laser, measuring spectral characteristics of the diffraction grating, and allowing the diffraction grating to self-write from interference between a forward beam and a Fresnel reflection, such that the diffraction grating is adjusted for changes in ambient conditions.

摘要翻译： 本发明提供了一种用于将衍射光栅调节到环境条件变化的方法。 该方法包括用激光器在光折射波导中写入衍射光栅，测量衍射光栅的光谱特性，并允许衍射光栅从前向光束和菲涅耳反射之间的干涉自写入，使得衍射光栅被调整 用于环境条件的变化。

公开(公告)号：US08018648B1

公开(公告)日：2011-09-13

申请号：US12214294

申请日：2008-06-12

申请人： Gary Cook ,  Dean R. Evans ,  Anatoly Gluschenko ,  Victor Yu Reshetnyak

发明人： Gary Cook ,  Dean R. Evans ,  Anatoly Gluschenko ,  Victor Yu Reshetnyak

IPC分类号： H01S5/00

CPC分类号： H01S3/2308 ,  H01S3/0612 ,  H01S3/094 ,  H01S5/041 ,  H01S5/1067 ,  H01S5/50 ,  Y10S977/932 ,  Y10S977/951

摘要： The present invention provides a photorefractive hybrid cell including a window and a gain media disposed adjacent the window. The gain media includes nanoparticles therein. The window includes a material that forms a space-charge field. The gain media includes a material having refractive index properties that depend on an electric field. The nanoparticles include a material which responds orientationally to the presence of an electric or a magnetic field.

摘要翻译： 本发明提供一种光折射混合电池，其包括窗口和邻近窗口设置的增益介质。 增益介质包括纳米颗粒。 窗口包括形成空间电荷场的材料。 增益介质包括具有取决于电场的折射率特性的材料。 纳米颗粒包括对电场或磁场的存在进行取向的材料。

公开(公告)号：US20050270747A1

公开(公告)日：2005-12-08

申请号：US11129604

申请日：2005-05-13

申请人： Tony Rogers ,  Clark Wilson ,  Gary Cook

发明人： Tony Rogers ,  Clark Wilson ,  Gary Cook

IPC分类号： G02B20060101 ,  H04N5/74 ,  H05K7/20

CPC分类号： H04N9/3144 ,  G03B21/16 ,  H04N5/7441 ,  H04N9/3141

摘要： A projection device is provided, wherein the projection device includes a digital micromirror device, a circuit board that further includes a first face and a second face, an integrated heat sink/stiffener; and a plurality of engagement mechanisms, wherein the plurality of engagement mechanisms is adapted to operatively couple the digital micromirror device to the first face of the circuit board and to secure the integrated heat sink/stiffener to the second face of the circuit board; and wherein the integrated heat sink/stiffener is adapted to provide structural support to the circuit board and to draw thermal energy away from the digital micromirror device.

公开(公告)号：US5379147A

公开(公告)日：1995-01-03

申请号：US960386

申请日：1993-01-11

申请人： Gary Cook

发明人： Gary Cook

IPC分类号： G02F1/35 ,  H01S3/10 ,  H01S3/108 ,  H01S3/23 ,  H01S3/30 ,  H01S3/08

CPC分类号： H01S3/307 ,  G02F1/3538 ,  H01S3/2358 ,  H01S3/10076 ,  H01S3/2333

摘要： A dye laser amplifier is formed by a stimulated brillouin scattering (SBS) dye cell which receives both dye laser light to be amplified and a pump beam along a common optical path. Phase conjugation and amplification of received energy are reflected from the SBS cell. The cell comprises an SBS medium that is a solvent for the laser dye used. Typical SBS mediums are methanol, acetone, isopropyl alcohol, etc. Typical dyes are Rhodamine 6G, Rhodamine B, Rhodamine 560, Rhodamine 575, Sulphorhodamine B, Kiton Red, DCM, Courrarun 523, etc. A plurality of amplifiers may be connected in series to provide increased amplification. The action of the phase conjugation corrects optical distorsions, thereby preserving beam quality and bandwidth even after multiple amplifications. A typical dye laser beam of 590 nm wavelength, about 1 .mu.J may be amplified to about 120 mJ, with a 17 nsec pulse width, and

摘要翻译： PCT No.PCT / GB92 / 00410 Sec。 371日期：1993年1月11日 102（e）日期1993年1月11日PCT 1991年3月9日PCT公布。 公开号WO92 / 16038 日期：1992年9月17日。染料激光放大器由受激布里渊散射（SBS）染料单元形成，其接收要放大的染料激光和沿着公共光路的泵浦光束。 接收能量的相位共轭和放大反映在SBS单元中。 该细胞包含作为所用激光染料的溶剂的SBS培养基。 典型的SBS培养基是甲醇，丙酮，异丙醇等。典型的染料是罗丹明6G，罗丹明B，罗丹明560，罗丹明575，磺酰罗丹明B，Kiton Red，DCM，Courrarun 523等。多个放大器可以串联连接 以提供增加的扩增。 相位共轭的作用校正光学变形，从而即使在多次放大之后也能保持光束质量和带宽。 590nm波长的典型染料激光束，约1μJ可以被放大到约120mJ，具有17nsec的脉冲宽度和<500MHz的带宽。

公开(公告)号：US09188820B1

公开(公告)日：2015-11-17

申请号：US12797687

申请日：2010-06-10

申请人： Dean R. Evans ,  Gary Cook

发明人： Dean R. Evans ,  Gary Cook

IPC分类号： G02F1/135

CPC分类号： G02F1/135 ,  G02F1/1354

摘要： An optical filter or valve comprises autonomously tunable liquid crystal filters in which photoactivated materials such as a photoconductive and photovoltaic substrates or films are used to produce or control application of an electric field to a liquid crystal material to tune the liquid crystal material to the wavelength of the incident light or radiation that is illuminating the filter thereby enabling the filter to automatically and autonomously filter the incident light or radiation.

摘要翻译： 光学滤波器或阀包括自主调节的液晶滤波器，其中使用诸如光电导和光电衬底或膜的光活化材料来产生或控制向液晶材料施加电场以将液晶材料调谐到 照射过滤器的入射光或辐射，从而使得过滤器能够自动和自主地过滤入射光或辐射。