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公开(公告)号:US07612238B2
公开(公告)日:2009-11-03
申请号:US10526760
申请日:2003-09-12
IPC分类号: C07C211/27 , C07F9/09 , A61K31/135
CPC分类号: C07C217/64 , C07C215/28 , C07C225/16 , C07F9/094
摘要: Compounds of formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
摘要翻译: 其中R 1,R 2,R 3,R 4和R 5如说明书中所定义的式I化合物的制备方法,其用途和含有它们的药物组合物。
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2.Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator 失效
标题翻译: 氨基丙醇衍生物作为鞘氨醇-1-磷酸受体调节剂公开(公告)号:US07625950B2
公开(公告)日:2009-12-01
申请号:US10554556
申请日:2004-04-29
申请人: Klaus Hinterding , Carsten Spanka , Frédéric Zecri
发明人: Klaus Hinterding , Carsten Spanka , Frédéric Zecri
IPC分类号: A01N33/02 , A61K31/135 , A01N31/14 , A61K31/045 , A01N31/00
CPC分类号: C07D317/64 , C07C217/72 , C07F9/094 , C07F9/65744
摘要: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and n are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
摘要翻译: 其中R 1,R 2,R 3,R 4,R 5,R 6,R 7,X,Y和n如说明书中所定义的式(I)化合物处理其制备方法,其用途和含有它们的药物组合物。
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公开(公告)号:US20060166940A1
公开(公告)日:2006-07-27
申请号:US10526760
申请日:2003-09-12
IPC分类号: A61K31/66 , A61K31/137 , C07F9/02
CPC分类号: C07C217/64 , C07C215/28 , C07C225/16 , C07F9/094
摘要: Compounds of formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
摘要翻译: 其中R 1,R 2,R 3,R 4和R 5的式I化合物 在说明书中定义,其生产方法,用途和含有它们的药物组合物。
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4.Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator 失效
标题翻译: 氨基丙醇衍生物作为鞘氨醇-1-磷酸受体调节剂公开(公告)号:US20060211658A1
公开(公告)日:2006-09-21
申请号:US10554556
申请日:2004-04-29
申请人: Klaus Hinterding , Carsten Spanka , Frederic Zecri
发明人: Klaus Hinterding , Carsten Spanka , Frederic Zecri
IPC分类号: A61K31/66 , A61K31/277 , A61K31/137 , C07F9/02
CPC分类号: C07D317/64 , C07C217/72 , C07F9/094 , C07F9/65744
摘要: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and n are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
摘要翻译: 其中R 1,R 2,R 3,R 4,R 3,R 3,R 3, R 5,R 6,R 7,X,Y和n如说明书中所定义,其制备方法及其用途和药物组合物含有 他们。
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5.2,4- Di(hetero)-arylamino-pyrimidine derivatives as ZAP-70 and/or SYK inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,为ZAP-70和/或SYK抑制剂公开(公告)号:US08283356B2
公开(公告)日:2012-10-09
申请号:US12686863
申请日:2010-01-13
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: C07D405/12 , C07D239/48 , C07D413/14 , A61K31/506
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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6.2,4 Di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or syk inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,如ZAP-70和/或syk抑制剂公开(公告)号:US20060247262A1
公开(公告)日:2006-11-02
申请号:US11377716
申请日:2006-03-16
申请人: Rolf Baenteli , Marie Bernhard , Peter Buehlmayer , Nigel Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Bernhard , Peter Buehlmayer , Nigel Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: A61K31/506 , C07D403/02
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9,Z具有 如权利要求1所述的含义,其具有有趣的药物性质。
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7.2,4- Di(hetero)-arylamino-pyrimidine Derivatives as ZAP-70 and/or SYK inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,为ZAP-70和/或SYK抑制剂公开(公告)号:US20100152182A1
公开(公告)日:2010-06-17
申请号:US12686863
申请日:2010-01-13
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: A61K31/5377 , C07D239/69 , A61K31/506 , A61P35/00 , A61P37/00 , A61P7/00 , C07D413/14
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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8.2,4 Di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or syk inhibitors 失效
标题翻译: 2,4-二(杂) - 芳基氨基 - 嘧啶衍生物,如ZAP-70和/或syk抑制剂公开(公告)号:US07671063B2
公开(公告)日:2010-03-02
申请号:US11377716
申请日:2006-03-16
申请人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
发明人: Rolf Baenteli , Marie Claude Bernhard , Peter Buehlmayer , Nigel Graham Cooke , Rudolf Duthaler , Klaus Hinterding , Gebhard Thoma , Maurice Van Eis , Anette Von Matt , Louis Walliser , Gerhard Zenke
IPC分类号: C07D405/12 , C07D239/48 , C07D413/14 , A61K31/506
CPC分类号: C07D239/48 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , Y02P20/582
摘要: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
摘要翻译: 公开了下式的嘧啶衍生物其中R 0,R 1,R 3至R 9和Z具有如权利要求1所示的含义,其具有有趣的药物性质。
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公开(公告)号:US07943627B2
公开(公告)日:2011-05-17
申请号:US10507060
申请日:2003-03-14
申请人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
发明人: Rolf Baenteli , Gerhard Zenke , Nigel Graham Cooke , Rudolf Duthaler , Gebhard Thoma , Anette Von Matt , Toshiyuki Honda , Naoko Matsuura , Kazuhiko Nonomura , Osamu Ohmori , Ichiro Umemura , Klaus Hinterding , Christos Papageorgiou
IPC分类号: C07D239/48 , A61K31/505
CPC分类号: C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要: There are provided compounds of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译: 提供式I化合物,其中X,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8和R 9如权利要求1所述,其可用于ZAP-70和/或Syk抑制起作用或 由与FAK连接的信号级联故障引起的。
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公开(公告)号:US07169817B2
公开(公告)日:2007-01-30
申请号:US10445967
申请日:2003-05-27
申请人: Shifeng Pan , Nathanael S. Gray , Wenqui Gao , Klaus Hinterding , Sophie Lefebvre , Yuan Mi , Peter Nussbaumer , Wei Wang , Federic Zecri , Fan Yi , Lawrence Blas Perez , Kenneth Richad la Montagne , Peter Ettmayer
发明人: Shifeng Pan , Nathanael S. Gray , Wenqui Gao , Klaus Hinterding , Sophie Lefebvre , Yuan Mi , Peter Nussbaumer , Wei Wang , Federic Zecri , Fan Yi , Lawrence Blas Perez , Kenneth Richad la Montagne , Peter Ettmayer
IPC分类号: C07C211/03 , C07C251/32 , A61K31/15 , A61K31/137
CPC分类号: C07D263/57 , C07C215/28 , C07C215/46 , C07C217/54 , C07C237/30 , C07C251/48 , C07C255/13 , C07C255/43 , C07C255/58 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D261/08 , C07D317/58 , C07D333/20 , C07F9/094
摘要: The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them. Compounds according to the present invention are based upon the chemical formula: wherein the substituents have the values mentioned herein.
摘要翻译: 本发明涉及联苯衍生物,其制备方法及其用途和含有它们的药物组合物。 根据本发明的化合物基于以下化学式:其中取代基具有本文提及的值。
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