公开(公告)号：US06344481B1

公开(公告)日：2002-02-05

申请号：US09488110

申请日：2000-01-20

申请人： Peter Cornelius ,  Diane M. Hargrove ,  Bradley P. Morgan ,  Andrew G. Swick

发明人： Peter Cornelius ,  Diane M. Hargrove ,  Bradley P. Morgan ,  Andrew G. Swick

IPC分类号： A61K3124

CPC分类号： A61K31/216 ,  A61K31/195 ,  A61K31/198 ,  A61K31/215 ,  A61K2300/00 ,  A61K31/00

摘要： The invention relates to pharmaceutical compositions and methods useful in the treatment of obesity which methods comprise administering to animal, including a human or companion animal, in need of such treatment an effective amount of a compound of the structural formula or a pharmaceutically acceptable salt, racemate or enantiomer thereof, wherein R is hydroxy, esterified hydroxy or etherified hydroxy; R1 and R2 are, independently, halogen, trifluoromethyl or lower alkyl; R3 is halogen, trifluoromethyl, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl, carbocyclic arylmethyl, carbocyclic aroyl, carbocyclic arylhydroxymethyl; or R3 is the radical wherein R8 is hydrogen, lower alkyl, aryl, cycloalkyl, aryl-lower alkyl or cycloalkyl-lower alkyl; R6 is hydroxy or acyloxy; R10 is hydrogen or lower alkyl; or R9 and R10, taken together with the carbon atom to which they are attached, form a carbonyl group; R4 is hydrogen, halogen, trifluoromethyl or lower alkyl; R5 and R6 are, independently, hydrogen or lower alkyl or R5 and R6, taken together with the carbon atom to which they are attached, form a carbonyl group; X is O, S or —NR7; R7 is hydrogen or lower alkyl; W is O or S; and Z is carboxyl or carboxyl derivatized as a pharmaceutically acceptable ester or amide. The invention further provides for pharmaceutical compositions and methods of using the compounds of structural formula (I), or the pharmaceutically acceptable salts, racemates and enantiomers thereof, in combination with an anorectic agent, in treating obesity.

摘要翻译： 本发明涉及可用于治疗肥胖症的药物组合物和方法，该方法包括向需要这种治疗的动物，包括人或伴侣动物施用有效量的结构式化合物或其药学上可接受的盐，外消旋体或 其中R是羟基，酯化的羟基或醚化羟基; R 1和R 2独立地是卤素，三氟甲基或低级烷基; R 3是卤素，三氟甲基，低级烷基，芳基，芳基 - 低级烷基，环烷基或环烷基 - 低级烷基， 碳环芳基甲基，碳环芳酰基，碳环芳基羟甲基; 或R 3是其中R 8是氢，低级烷基，芳基，环烷基，芳基 - 低级烷基或环烷基 - 低级烷基的基团; R 6是羟基或酰氧基; R 10是氢或低级烷基; 或R 9和R 10与它们所连接的碳原子一起形成羰基; R 4是氢，卤素，三氟甲基或低级烷基; R 5和R 6独立地是氢或低级烷基或R 5和R 6，取代 与它们所连接的碳原子一起形成羰基; X是O，S或-NR 7; R 7是氢或低级烷基; W是O或S; 并且Z是作为药学上可接受的酯或酰胺衍生的羧基或羧基。本发明还提供了药物组合物和使用结构式（I）化合物或其药学上可接受的盐，外消旋体和对映异构体与厌食症 代理，治疗肥胖。

公开(公告)号：US06555578B2

公开(公告)日：2003-04-29

申请号：US09978980

申请日：2001-10-16

申请人： Peter Cornelius ,  Diane Hargrove ,  Bradley P. Morgan ,  Andrew G. Swick

发明人： Peter Cornelius ,  Diane Hargrove ,  Bradley P. Morgan ,  Andrew G. Swick

IPC分类号： A61K3124

CPC分类号： A61K31/216 ,  A61K31/195 ,  A61K31/198 ,  A61K31/215 ,  A61K2300/00 ,  A61K31/00

摘要： The invention relates to pharmaceutical compositions and methods useful in the treatment of obesity which methods comprise administering to animal, including a human or companion animal, in need of such treatment an effective amount of a compound of the structural formula or a pharmaceutically acceptable salt, racemate or enantiomer thereof, wherein R is hydroxy, esterified hydroxy or etherified hydroxy; R1 and R2 are, independently, halogen, trifluoromethyl or lower alkyl; R3 is halogen, trifluoromethyl, lower alkyl, aryl, aryl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl, carbocyclic arylmethyl, carbocyclic aroyl, carbocyclic arylhydroxymethyl; or R3 is the radical  wherein R8 is hydrogen, lower alkyl, aryl, cycloalkyl, aryl-lower alkyl or cycloalkyl-lower alkyl; R9 is hydroxy or acyloxy; R10 is hydrogen or lower alkyl; or R9 and R10, taken together with the carbon atom to which they are attached, form a carbonyl group; R4 is hydrogen, halogen, trifluoromethyl or lower alkyl; R5 and R6 are, independently, hydrogen or lower alkyl or R5 and R6, taken together with the carbon atom to which they are attached, form a carbonyl group; X is O, S or —NR7; R7 is hydrogen or lower alkyl; W is O or S; and Z is carboxyl or carboxyl derivatized as a pharmaceutically acceptable ester or amide. The invention further provides for pharmaceutical compositions and methods of using the compounds of structural formula (I), or the pharmaceutically acceptable salts, racemates and enantiomers thereof, in combination with an anorectic agent, in treating obesity.

摘要翻译： 本发明涉及可用于治疗肥胖症的药物组合物和方法，该方法包括向需要这种治疗的动物，包括人或伴侣动物施用有效量的结构式化合物或其药学上可接受的盐，外消旋体或 其中R是羟基，酯化的羟基或醚化羟基; R 1和R 2独立地是卤素，三氟甲基或低级烷基; R 3是卤素，三氟甲基，低级烷基，芳基，芳基 - 低级烷基，环烷基或环烷基 - 低级烷基， 碳环芳基甲基，碳环芳酰基，碳环芳基羟甲基; 或R 3是其中R 8是氢，低级烷基，芳基，环烷基，芳基 - 低级烷基或环烷基 - 低级烷基的基团; R 9是羟基或酰氧基; R 10是氢或低级烷基; 或R 9和R 10与它们所连接的碳原子一起形成羰基; R 4是氢，卤素，三氟甲基或低级烷基; R 5和R 6独立地是氢或低级烷基或R 5和R 6，取代 与它们所连接的碳原子一起形成羰基; X是O，S或-NR 7; R 7是氢或低级烷基; W是O或S; 并且Z是作为药学上可接受的酯或酰胺衍生的羧基或羧基。本发明还提供了药物组合物和使用结构式（I）化合物或其药学上可接受的盐，外消旋体和对映异构体与厌食症 代理，治疗肥胖。

公开(公告)号：US20090173722A1

公开(公告)日：2009-07-09

申请号：US12299415

申请日：2007-05-02

申请人： Peter Cornelius ,  Axel Luft ,  Mirko Weiland

发明人： Peter Cornelius ,  Axel Luft ,  Mirko Weiland

IPC分类号： B23K26/00

CPC分类号： B23K1/0056 ,  B23K26/242 ,  B23K33/008 ,  B23K37/0408 ,  B23K2101/006

摘要： A method provides for joining an outer sheet and an inner sheet, in particular of an attachment part of a motor vehicle body. On the visible sides of an attachment part, a welding or brazing seam is produced between a fold of an outer sheet and an inner sheet. The outer sheet is held in a bed, and the inner sheet is pressed against the fold on an inner side thus forming a joining groove. To ensure that during beam welding or beam grazing the inner sheet is held in position on the fold, it is prevented from moving away without clamping by stops on an outer side. These stops are disposed in a row along the welding or brazing seam and in dependence upon the progress of the joining procedure can be moved individually out of a path of a welding or brazing head.

摘要翻译： 一种方法提供一种外部片材和内部片材，特别是机动车辆车身的附接部分的接合。 在附件的可见侧，在外片的折叠部和内片之间产生焊接或钎焊接缝。 外片被保持在床上，并且内片在内侧被压靠在折叠上，从而形成接合槽。 为了确保在射束焊接或射束放牧期间，内部片材保持在折叠部分上的位置，防止其在外侧被止动件夹紧而移开。 这些止动件沿着焊接或钎焊接缝排列成一列，并且根据接合过程的进展可以单独地移出焊接头或钎焊头的路径。

公开(公告)号：US20110318126A1

公开(公告)日：2011-12-29

申请号：US13254592

申请日：2010-01-14

申请人： Peter Cornelius ,  Matthias Eisner ,  Thomas Hahn ,  Stefan Kaiser ,  Helmut Kasper ,  Artur Klink ,  Michael Klos ,  Christoph Olaineck ,  Michael Schultz

发明人： Peter Cornelius ,  Matthias Eisner ,  Thomas Hahn ,  Stefan Kaiser ,  Helmut Kasper ,  Artur Klink ,  Michael Klos ,  Christoph Olaineck ,  Michael Schultz

IPC分类号： B23B39/14 ,  B23Q17/22 ,  B23Q17/24 ,  B23B49/00

CPC分类号： B23B49/00 ,  B23B39/14 ,  B23B2215/04 ,  B23B2260/0485 ,  B23Q3/002 ,  B23Q17/2275 ,  G05B19/402 ,  Y10T408/03 ,  Y10T408/675

摘要： The invention relates to a machining device for machining a workpiece (W), wherein a rotatably mounted machining tool (2a) is held in a machining unit (2), and the machining unit (2) can be moved axially along the axis of rotation (X) of the machining tool (2a) by means of a feed device (10). The machining device comprises a pressure plate (6), mounted in a freely movable manner by means of a bearing device (4), and a measuring device (8) for position detection. According to the invention, the pressure plate (6) and the bearing device (4) constitute part of a pressure-exerting unit (12), and the pressure-exerting unit (12) can be moved axially with respect to the machining unit (2) in the direction of the axis of rotation (X) and independently of the machining unit (2) by means of a drive device (14) assigned to said pressure-exerting unit.

摘要翻译： 本发明涉及一种用于加工工件（W）的加工装置，其中可旋转地安装的加工工具（2a）保持在加工单元（2）中，并且加工单元（2）可沿着旋转轴线轴向移动 （10）的加工工具（2a）的上表面（X）。 加工装置包括通过轴承装置（4）以可自由移动的方式安装的压板（6）和用于位置检测的测量装置（8）。 根据本发明，压板（6）和轴承装置（4）构成施压单元（12）的一部分，并且压力施加单元（12）可以相对于加工单元轴向移动 2）沿着旋转轴线（X）的方向，并且通过分配给所述压力施加单元的驱动装置（14）独立于加工单元（2）。

公开(公告)号：US20090196823A1

公开(公告)日：2009-08-06

申请号：US11658989

申请日：2005-09-16

申请人： Peter Cornelius ,  Ronald P. Gladue ,  Robert S. Garofalo

发明人： Peter Cornelius ,  Ronald P. Gladue ,  Robert S. Garofalo

IPC分类号： A61K49/00 ,  A61K39/395 ,  G01N33/68

CPC分类号： G01N33/6863 ,  A61K38/00 ,  G01N2500/00 ,  G01N2800/042 ,  G01N2800/044

摘要： The present invention provides methods to decrease or maintain body weight and/or body fat in patients, e.g. humans and animals, for example in the treatment of overweight or obese patients, or as a means to produce leaner meat in food stock animals, e.g., cattle, chickens, pigs, alone or in combination with second therapeutic agent; methods to treat diabetes and/or glucose intolerance; and methods to treat metabolic syndrome disorders in patients in need thereof, by administering a CCR2 therapeutic agent, kits for the above-identified therapeutic uses, and methods of identifying CCR2 therapeutic agents for treating the above-described therapeutic uses.

摘要翻译： 本发明提供了降低或维持患者体重和/或体脂肪的方法，例如， 人和动物，例如在超重或肥胖患者的治疗中，或作为在食物动物例如牛，鸡，猪中单独或与第二治疗剂组合地产生瘦肉的手段; 治疗糖尿病和/或葡萄糖不耐受的方法; 以及通过施用CCR2治疗剂，用于上述治疗用途的试剂盒和鉴定用于治疗上述治疗用途的CCR2治疗剂的方法来治疗有需要的患者中的代谢综合征障碍的方法。

公开(公告)号：US20060273620A1

公开(公告)日：2006-12-07

申请号：US10553116

申请日：2004-04-02

申请人： Jens Husner ,  Peter Cornelius ,  Axel Luft

发明人： Jens Husner ,  Peter Cornelius ,  Axel Luft

IPC分类号： B60J10/08

CPC分类号： B23K33/008 ,  B23K26/242 ,  B23K26/244 ,  Y10T29/49622 ,  Y10T29/49908

摘要： A method for producing attached parts for a motor vehicle, for example doors, dampers, mudguards formed by internal (1) and external (2) sheets. The external sheet (2) is inward bent in the visible areas of the door or attached part, the sheet edges being practically parallel to the plane of attached parts in the invisible (not apparently visible) areas of the door or attached part. The internal sheet (1) is pushed against the external sheet (2) in a flanged area in such a way that a small accurately defined gap for laser welding is produced. The internal (1) and external (2) sheets are welded to each other in the form of an overlap joint in the opposite invisible areas, thereby compensating tolerances.

摘要翻译： 一种用于制造用于机动车辆的附接部件的方法，例如由内部（1）和外部（2）板形成的门，阻尼器，挡泥板。 外部片材（2）在门或附接部件的可见区域中向内弯曲，片材边缘实际上平行于门或附接部件的不可见（不可见）区域中的附接部件的平面。 内部片材（1）在法兰区域中被推压到外部片材（2）上，使得产生用于激光焊接的小的精确限定的间隙。 内部（1）和外部（2）板在相反的不可见区域中以重叠接头的形式彼此焊接，从而补偿公差。

公开(公告)号：US08299399B2

公开(公告)日：2012-10-30

申请号：US12598496

申请日：2008-04-10

申请人： Peter Cornelius ,  Uwe Feis ,  Michael Klos ,  Stefan Leidinger ,  Thomas Ralle

发明人： Peter Cornelius ,  Uwe Feis ,  Michael Klos ,  Stefan Leidinger ,  Thomas Ralle

IPC分类号： B21J1/06 ,  B21J5/08

CPC分类号： B21D39/021 ,  B23K11/14 ,  B23K2101/006 ,  Y10T29/49622 ,  Y10T29/53709 ,  Y10T29/53791

摘要： A device (1) is provided for connecting a metal sheet (23, 33′) at the edges, particularly body sheet metal in automobiles. The device (1) includes at least one folding bed (2) for receiving at least two metal sheets, folding jaws (3) which are functionally connected to associated folding jaw supports (4), at least one thermal jointing tool (5), and at least one mass electrode (9, 9′). At least the joining tool is not attached to the folding jaws, and the joining tool contains a lever oriented away from the folding bed as a linear feed device. The lever (6) has a center of rotation (10) outside the folding bed, wherein the joining tool can swivel in the manner of a knee lever into an operating and/or non-operating position.

摘要翻译： 提供一种装置（1），用于在边缘处连接金属片（23,33'），特别是汽车中的身体金属片。 所述装置（1）包括至少一个折叠床（2），用于容纳至少两个金属板，功能上连接到相关联的折叠夹爪支撑件（4）的折叠爪（3），至少一个热连接工具（5） 和至少一个质量电极（9,9'）。 至少连接工具不附接到折叠夹爪，并且接合工具包含作为线性进给装置的远离折叠床的杠杆。 杠杆（6）在折叠床的外侧具有旋转中心（10），其中接合工具可以以拐弯杆的方式旋转到操作和/或非操作位置。

公开(公告)号：US20110320031A1

公开(公告)日：2011-12-29

申请号：US13254552

申请日：2010-01-14

申请人： Peter Cornelius ,  Matthias Eisner ,  Thomas Hahn ,  Stefan Kaiser ,  Helmut Kasper ,  Artur Klink ,  Michael Klos ,  Christoph Olaineck ,  Michael Schultz

发明人： Peter Cornelius ,  Matthias Eisner ,  Thomas Hahn ,  Stefan Kaiser ,  Helmut Kasper ,  Artur Klink ,  Michael Klos ,  Christoph Olaineck ,  Michael Schultz

IPC分类号： G05B19/19

CPC分类号： B23Q1/545 ,  B23Q1/32 ,  B23Q3/069 ,  B23Q17/2233

摘要： The invention relates to a machining device for machining a workpiece, wherein a rotatably mounted machining tool (2a) is held in a machining unit (2), and the axis of rotation (X) of the machining tool (2a) can be aligned with the workpiece surface to be machined, and therefore the axis of rotation (X) coincides with the geometric normal (N) in the machining point of the workpiece surface. The machining device comprises a pressure plate (6) mounted in a freely rotatable manner on the machining device via a bearing device (4), and a measuring device (8) for detecting a deviation in the position of the pressure plate (6). According to the invention, the bearing device (4) has a bearing body (40b) having at least one spherical surface region, and a bearing receptacle (40a) which surrounds the bearing body (40b) at the spherical surface regions in a form-fitting manner.

摘要翻译： 本发明涉及一种用于加工工件的加工装置，其中可旋转地安装的加工工具（2a）保持在加工单元（2）中，并且加工工具（2a）的旋转轴线（X）可以与 要加工的工件表面，因此旋转轴线（X）与工件表面加工点的几何法线（N）重合。 加工装置包括经由轴承装置（4）以可自由旋转的方式安装在加工装置上的压板（6），以及用于检测压板（6）的位置偏差的测量装置（8）。 根据本发明，轴承装置（4）具有至少一个球形表面区域的轴承体（40b）和在球形表面区域周围围绕轴承体（40b）的轴承座（40a） 适合的方式。

公开(公告)号：US5433147A

公开(公告)日：1995-07-18

申请号：US209881

申请日：1994-03-14

申请人： Uwe Brede ,  Anton Bretfeld ,  Peter Cornelius ,  Hans Jena

发明人： Uwe Brede ,  Anton Bretfeld ,  Peter Cornelius ,  Hans Jena

IPC分类号： B60R22/46 ,  F42B3/12 ,  F42B3/18 ,  F42C19/12

CPC分类号： F42B3/103

摘要： An electrical ignition device (1) has a metal container (2) for a firing resistor or bridge, a first (3) and a second (4) terminal pin and at least one ignition charge (5, 6).So that firing of the ignition charge does not occur in the event of electrical discharges between terminal pins and a housing, it is proposed that the container (2) be capable of being embedded in a plastic material by injection moulding and inserted in the housing, that a first outward extension (8) be provided on the container (2) which is electrically conductively connected to the first terminal pin (3), and that a second outward extension (9) be provided on the container (2) which can be formed so as to extend to the housing leaving a small clearance and of which an outer end is not embedded in the plastic material.

摘要翻译： 电气点火装置（1）具有用于点火电阻器或桥梁的金属容器（2），第一（3）和第二（4）端子销和至少一个点火充电装置（5,6）。 因此，在端子销和壳体之间放电的情况下，不会发生点火电荷的点火，因此建议容器（2）能够通过注射成型嵌入塑料材料并插入壳体中， 在与第一端子销（3）导电连接的容器（2）上设置有第一向外延伸部（8），并且在容器（2）上设置第二向外延伸部（9） 形成为延伸到壳体留下小的间隙，并且其外端未嵌入在塑料材料中。

公开(公告)号：US08001688B2

公开(公告)日：2011-08-23

申请号：US10553116

申请日：2004-04-02

申请人： Jens Husner ,  Peter Cornelius ,  Axel Luft

发明人： Jens Husner ,  Peter Cornelius ,  Axel Luft

IPC分类号： B21D53/88

CPC分类号： B23K33/008 ,  B23K26/242 ,  B23K26/244 ,  Y10T29/49622 ,  Y10T29/49908

摘要： A method for producing attached parts for a motor vehicle, for example doors, dampers, mudguards formed by internal (1) and external (2) sheets. The external sheet (2) is inward bent in the visible areas of the door or attached part, the sheet edges being practically parallel to the plane of attached parts in the invisible (not apparently visible) areas of the door or attached part. The internal sheet (1) is pushed against the external sheet (2) in a flanged area in such a way that a small accurately defined gap for laser welding is produced. The internal (1) and external (2) sheets are welded to each other in the form of an overlap joint in the opposite invisible areas, thereby compensating tolerances.

摘要翻译： 一种用于制造用于机动车辆的附接部件的方法，例如由内部（1）和外部（2）板形成的门，阻尼器，挡泥板。 外部片材（2）在门或附接部件的可见区域中向内弯曲，片材边缘实际上平行于门或附接部件的不可见（不可见）区域中的附接部件的平面。 内部片材（1）在法兰区域中被推压到外部片材（2）上，使得产生用于激光焊接的小的精确限定的间隙。 内部（1）和外部（2）板在相反的不可见区域中以重叠接头的形式彼此焊接，从而补偿公差。