公开(公告)号：US5968938A

公开(公告)日：1999-10-19

申请号：US86107

申请日：1998-05-29

申请人： Peter D. Williams ,  Michelle A. Sparks ,  Ian Bell ,  James P. Guare, Jr. ,  Roger M. Freidinger

发明人： Peter D. Williams ,  Michelle A. Sparks ,  Ian Bell ,  James P. Guare, Jr. ,  Roger M. Freidinger

IPC分类号： C07D211/46 ,  C07D211/96 ,  C07D213/74 ,  C07D235/06 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185 ,  A61K31/495 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D213/74 ,  C07D211/46 ,  C07D211/96 ,  C07D235/06 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185

摘要： This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

摘要翻译： 本发明涉及某些新的哌嗪化合物及其衍生物，其合成及其作为催产素受体拮抗剂的用途。 这些化合物的一种应用是在哺乳动物，特别是人类中治疗早产。 化合物放松哺乳动物子宫收缩的能力也使它们可用于治疗痛经并在剖宫产分娩前停止劳动。

公开(公告)号：US06090805A

公开(公告)日：2000-07-18

申请号：US095232

申请日：1998-06-10

申请人： Peter D. Williams ,  Michelle A. Sparks ,  Ian Bell ,  Debra S. Perlow ,  Kenneth Stauffer ,  Roger M. Freidinger

发明人： Peter D. Williams ,  Michelle A. Sparks ,  Ian Bell ,  Debra S. Perlow ,  Kenneth Stauffer ,  Roger M. Freidinger

IPC分类号： C07D413/04 ,  C07D413/14 ,  A61K31/535 ,  A61K31/47 ,  C07D215/16 ,  C07D265/12

CPC分类号： C07D413/04 ,  C07D413/14

摘要： This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

摘要翻译： 本发明涉及某些新的苯并恶嗪酮化合物及其衍生物，其合成及其作为催产素受体拮抗剂的用途。 这些化合物的一种应用是在哺乳动物，特别是人类中治疗早产。 化合物放松哺乳动物子宫收缩的能力也使它们可用于治疗痛经并在剖宫产分娩前停止劳动。

公开(公告)号：US20070293470A1

公开(公告)日：2007-12-20

申请号：US11660798

申请日：2005-09-09

申请人： Theresa Williams ,  Christopher Burgey ,  Thomas Tucker ,  Craig Stump ,  Ian Bell

发明人： Theresa Williams ,  Christopher Burgey ,  Thomas Tucker ,  Craig Stump ,  Ian Bell

IPC分类号： A61K31/55 ,  A61K31/40 ,  A61P25/06 ,  C07D211/00 ,  C07D223/02 ,  C07D267/02 ,  C07D223/00 ,  C07D209/54 ,  A61K31/44

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D413/12 ,  C07D519/00

摘要： The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I的化合物：I（其中变量A 1，A 2，B，J，K，m，n，R 4 R 5c，R 5b和R 5c如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗 或预防CGRP所涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20060148779A1

公开(公告)日：2006-07-06

申请号：US10547082

申请日：2004-03-10

申请人： Ian Bell ,  Cory Theberge ,  Theresa Williams ,  C. Blair Zartman ,  Xu-Fang Zhang ,  Steven Gallicchio

发明人： Ian Bell ,  Cory Theberge ,  Theresa Williams ,  C. Blair Zartman ,  Xu-Fang Zhang ,  Steven Gallicchio

IPC分类号： A61K31/553 ,  A61K31/551 ,  A61K31/537 ,  A61K31/513 ,  A61K31/427 ,  A61K31/421 ,  C07D417/02

CPC分类号： C07D235/02 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12

摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US08993588B2

公开(公告)日：2015-03-31

申请号：US12602676

申请日：2008-06-02

申请人： Ian Bell ,  Harold Selnick ,  C. Blair Zartman

发明人： Ian Bell ,  Harold Selnick ,  C. Blair Zartman

IPC分类号： A61K31/44 ,  C07D471/20 ,  C07D519/00

CPC分类号： C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物：其中变量A1，A2，B，m，n，J，R4，G1，G2，G3和Y如本文所述，其是CGRP受体的拮抗剂，其可用于治疗或预防疾病 其中涉及CGRP，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20110255842A1

公开(公告)日：2011-10-20

申请号：US13088331

申请日：2011-04-15

申请人： James Hindle ,  Paul Rechsteiner ,  Ian Bell ,  Michael Malcolm ,  Tom Barnett ,  Stephen Watson

发明人： James Hindle ,  Paul Rechsteiner ,  Ian Bell ,  Michael Malcolm ,  Tom Barnett ,  Stephen Watson

IPC分类号： H04N9/80

CPC分类号： G11B27/105 ,  G11B27/11 ,  G11B2220/2541 ,  G11B2220/2562 ,  H04N5/76

摘要： A method of providing a uniform user experience is described. The method entails receiving general preference information, and mapping the general preference information to format-specific preference information. This format-specific preference information can then be applied when accessing content.

摘要翻译： 描述了提供统一用户体验的方法。 该方法需要接收一般偏好信息，并将一般偏好信息映射到格式特定的偏好信息。 然后可以在访问内容时应用此格式特定的首选项信息。

公开(公告)号：US20100179166A1

公开(公告)日：2010-07-15

申请号：US12602676

申请日：2008-06-02

申请人： Ian Bell ,  Harold Selnick ,  C. Blair Zartman

发明人： Ian Bell ,  Harold Selnick ,  C. Blair Zartman

IPC分类号： A61K31/497 ,  C07D471/20 ,  A61K31/501 ,  A61K31/438 ,  A61P25/06

CPC分类号： C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物：其中变量A1，A2，B，m，n，J，R4，G1，G2，G3和Y如本文所述，其是CGRP受体的拮抗剂，其可用于治疗或预防疾病 其中涉及CGRP，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20100137328A1

公开(公告)日：2010-06-03

申请号：US12602681

申请日：2008-06-03

申请人： Ian Bell ,  Craig A. Stump

发明人： Ian Bell ,  Craig A. Stump

IPC分类号： A61K31/4985 ,  C07D221/20 ,  A61K31/438 ,  C07D245/04 ,  C07D241/52 ,  A61P25/06

CPC分类号： C07D519/00 ,  C07D471/06 ,  C07D487/06

摘要： Compounds of formula I: wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物：其中变量A1，A2，B，m，n，J，R4，G1，G2，G3和Y如本文所述，其是CGRP受体的拮抗剂，其可用于治疗或预防疾病 其中涉及CGRP，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20070111982A1

公开(公告)日：2007-05-17

申请号：US10546889

申请日：2004-03-10

申请人： Ian Bell ,  Steven Gallicchio ,  Craig Stump ,  C. Zartman

发明人： Ian Bell ,  Steven Gallicchio ,  Craig Stump ,  C. Zartman

IPC分类号： A61K31/553 ,  A61K31/4747 ,  A61K31/4188 ,  C07D413/02

CPC分类号： C07D233/78 ,  C07D235/02 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D471/10 ,  C07D513/04

摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20060211712A1

公开(公告)日：2006-09-21

申请号：US10549338

申请日：2004-03-10

申请人： Ian Bell ,  Steven Gallicchio ,  Cory Theberge ,  Xu-Fang Zhang ,  Craig Stump ,  C. Zartman

发明人： Ian Bell ,  Steven Gallicchio ,  Cory Theberge ,  Xu-Fang Zhang ,  Craig Stump ,  C. Zartman

IPC分类号： A61K31/522 ,  A61K31/52 ,  A61K31/4747 ,  A61K31/427 ,  A61K31/421 ,  A61K31/4164

CPC分类号： C07D401/14 ,  C07D233/76 ,  C07D235/02 ,  C07D235/26 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10

摘要： The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及下式的化合物：其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。