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公开(公告)号:US20050261332A1
公开(公告)日:2005-11-24
申请号:US11098315
申请日:2005-04-04
申请人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Jean-Francois Pons , Russell Thomas , Manuel Navia , Thomas Coulter , Jeffrey Saunders , Bard Geesaman
发明人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Jean-Francois Pons , Russell Thomas , Manuel Navia , Thomas Coulter , Jeffrey Saunders , Bard Geesaman
IPC分类号: A61K31/422 , A61K31/4245 , A61K31/454 , A61K31/4745 , C07C311/32 , C07D413/02 , C07D471/02 , C07D471/10 , C07D43/02
CPC分类号: C07D471/10 , C07C311/32 , C07D401/12
摘要: Compounds of formulas (I), (II), (III), and (IV) and methods of treating disorders by administering a compound of formula (I), (II), (III), or (IV) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.
摘要翻译: 本文描述式(I),(II),(III)和(IV)的化合物和通过施用式(I),(II),(III)或(IV)的化合物来治疗病症的方法。 病症的实例包括肿瘤性疾病,脂肪细胞相关疾病,神经变性疾病和代谢紊乱。
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公开(公告)号:US20050187237A1
公开(公告)日:2005-08-25
申请号:US10982997
申请日:2004-11-04
申请人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel Navia , Russell Thomas , Jean-Francois Pons , Jeffrey Saunders
发明人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel Navia , Russell Thomas , Jean-Francois Pons , Jeffrey Saunders
IPC分类号: A61K31/438 , A61K31/4747 , A61K31/5377 , C07D413/14 , C07D471/10
CPC分类号: C07D471/10 , C07D221/20 , C07D401/12
摘要: Compounds of formula (I) are described herein The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to treat obesity.
摘要翻译: 式(I)化合物在本文中描述。该化合物可用于例如调节生长激素促分泌素受体(GHS-R)。 在一些情况下,化合物可用于治疗肥胖症。
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公开(公告)号:US20090264410A1
公开(公告)日:2009-10-22
申请号:US12367585
申请日:2009-02-09
申请人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel A. Navia , Russell J. Thomas , Jean-Francois Pons , Jeffrey O. Saunders
发明人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel A. Navia , Russell J. Thomas , Jean-Francois Pons , Jeffrey O. Saunders
IPC分类号: A61K31/55 , A61K31/4747
CPC分类号: C07D471/10 , C07D221/20 , C07D401/12
摘要: Compounds of formula (I) are described herein The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to treat obesity.
摘要翻译: 式(I)化合物在本文中描述。该化合物可用于例如调节生长激素促分泌素受体(GHS-R)。 在一些情况下,化合物可用于治疗肥胖症。
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公开(公告)号:US07897765B2
公开(公告)日:2011-03-01
申请号:US12367585
申请日:2009-02-09
申请人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel A. Navia , Russell J. Thomas , Jean-Francois Pons , Jeffrey O. Saunders
发明人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel A. Navia , Russell J. Thomas , Jean-Francois Pons , Jeffrey O. Saunders
IPC分类号: C07D401/00
CPC分类号: C07D471/10 , C07D221/20 , C07D401/12
摘要: Compounds of formula (I) are described herein The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to treat obesity.
摘要翻译: 式(I)化合物在本文中描述。该化合物可用于例如调节生长激素促分泌素受体(GHS-R)。 在一些情况下,化合物可用于治疗肥胖症。
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公开(公告)号:US07504506B2
公开(公告)日:2009-03-17
申请号:US10982997
申请日:2004-11-04
申请人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel A. Navia , Russell J. Thomas , Jean-Francois Pons , Jeffrey O. Saunders
发明人: Peter Distefano , Andrew Napper , Rory Curtis , Jay Luly , Manuel A. Navia , Russell J. Thomas , Jean-Francois Pons , Jeffrey O. Saunders
IPC分类号: C07D215/00 , C07D209/00 , C07D491/00
CPC分类号: C07D471/10 , C07D221/20 , C07D401/12
摘要: Compounds of formula (I) are described herein The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to treat obesity.
摘要翻译: 式(I)化合物在本文中描述。该化合物可用于例如调节生长激素促分泌素受体(GHS-R)。 在一些情况下,化合物可用于治疗肥胖症。
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公开(公告)号:US20050070549A1
公开(公告)日:2005-03-31
申请号:US10487168
申请日:2002-11-13
申请人: Jay Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine Harriman , Kenneth Carson , Shomir Ghosh , Amy Elder , Karen Mattia
发明人: Jay Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine Harriman , Kenneth Carson , Shomir Ghosh , Amy Elder , Karen Mattia
IPC分类号: A61P1/00 , A61P3/10 , A61P29/00 , C07D211/46 , C07D211/52 , C07D313/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04 , C07D519/00 , A61K31/495 , A61K31/445 , C07D211/18 , C07D241/04
CPC分类号: C07D211/46 , C07D211/52 , C07D313/12 , C07D401/06 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由式(1)表示的化合物或其生理学上可接受的盐。
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公开(公告)号:US20070060592A1
公开(公告)日:2007-03-15
申请号:US11595653
申请日:2006-11-10
申请人: Jay Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine Harriman , Kenneth Carson , Shomir Ghosh , Amy Elder , Karen Mattia
发明人: Jay Luly , Yoshisuke Nakasato , Etsuo Ohshima , Geraldine Harriman , Kenneth Carson , Shomir Ghosh , Amy Elder , Karen Mattia
IPC分类号: A61K31/496 , A61K31/473 , C07D403/02 , C07D401/02
CPC分类号: C07D519/00 , C07D211/44 , C07D211/46 , C07D211/52 , C07D401/06 , C07D401/14 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物或其生理上可接受的盐。
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