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![[1,2,4]Thiadiazin-3-yl acetic acid compound and methods of making the acetic acid compound](/abs-image/US/2012/07/17/US08222404B2/abs.jpg.150x150.jpg)
1.发明授权[1,2,4]Thiadiazin-3-yl acetic acid compound and methods of making the acetic acid compound 有权[1,2,4]噻二嗪-3-基乙酸化合物和制备乙酸化合物的方法公开(公告)号：US08222404B2
公开(公告)日：2012-07-17
申请号：US13349705
申请日：2012-01-13
IPC分类号： C07D513/04
CPC分类号： C07D513/04 , C07D417/04
摘要： The invention is directed to a [7-methanesulfonylamino-methyl)-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-3-yl]-acetic acid compound and to methods of making the same.
摘要翻译： 本发明涉及[7-甲磺酰基氨基 - 甲基] -1,1-二氧代-1,4-二氢-1λ6-噻吩并[2,3-e] [1,2,4]噻二嗪-3-基] 乙酸化合物及其制备方法。
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![[1,2,4]thiadiazine 1,1-dioxide compounds](/abs-image/US/2012/01/17/US08097613B2/abs.jpg.150x150.jpg)
公开(公告)号：US08097613B2
公开(公告)日：2012-01-17
申请号：US12481391
申请日：2009-06-09
IPC分类号： C07D513/04 , A61K31/542
CPC分类号： C07D513/04 , C07D417/04
摘要： The invention is directed to [1,2,4]thiadiazine 1,1-dioxide compounds of formula I wherein A is B is and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译： 本发明涉及其中A为B的式I的[1,2,4]噻二嗪1,1-二氧化物化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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![Pyrro[1,2-b]pyridazinone intermediates](/abs-image/US/2010/11/30/US07842838B2/abs.jpg.150x150.jpg)
公开(公告)号：US07842838B2
公开(公告)日：2010-11-30
申请号：US12545547
申请日：2009-08-21
申请人： Stephen E. Webber , Frank Ruebsam , Martin Tran , Peter Dragovich , Liansheng Li , Douglas Eric Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
发明人： Stephen E. Webber , Frank Ruebsam , Martin Tran , Peter Dragovich , Liansheng Li , Douglas Eric Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
IPC分类号： C07C303/00
CPC分类号： C07D487/04
摘要： The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译： 本发明涉及吡咯并[1,2-b]哒嗪酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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![Pyrro[1,2-b]pyridazinone compounds](/abs-image/US/2009/09/01/US07582754B2/abs.jpg.150x150.jpg)
公开(公告)号：US07582754B2
公开(公告)日：2009-09-01
申请号：US12266190
申请日：2008-11-06
申请人： Stephen E. Webber , Frank Ruebsam , Martin Tran , Peter Dragovich , Liansheng Li , Douglas Eric Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
发明人： Stephen E. Webber , Frank Ruebsam , Martin Tran , Peter Dragovich , Liansheng Li , Douglas Eric Murphy , David Kucera , Zhongxiang Sun , Chinh Viet Tran
IPC分类号： C07D513/04 , A61K31/542 , A61K31/5415
CPC分类号： C07D487/04
摘要： The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译： 本发明涉及吡咯并[1,2-b]哒嗪酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号：US20100034773A1
公开(公告)日：2010-02-11
申请号：US12061499
申请日：2008-04-02
申请人： Chinh V. Tran , Frank Ruebsam , Douglas E. Murphy , Peter Dragovich , Yuefen Zhou , Lijian Chen , David Kucera , Fritz Blatter , Martin Viertelhaus
发明人： Chinh V. Tran , Frank Ruebsam , Douglas E. Murphy , Peter Dragovich , Yuefen Zhou , Lijian Chen , David Kucera , Fritz Blatter , Martin Viertelhaus
IPC分类号： A61K38/21 , C12N7/04 , A61P31/12 , A61K31/542 , A61K31/5415 , C07D285/26 , C07D279/16
CPC分类号： C07D417/04 , A61K31/5415 , A61K31/549 , A61K45/06 , C07D417/14 , C07D491/18 , C07D513/04
摘要： The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译： 本发明涉及5,6-二氢-1H-吡啶-2-酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号：US20080227774A1
公开(公告)日：2008-09-18
申请号：US12048933
申请日：2008-03-14
申请人： Frank Ruebsam , Peter Dragovich
发明人： Frank Ruebsam , Peter Dragovich
IPC分类号： A61K31/549 , C07D417/04 , C12N7/06 , A61P31/12
CPC分类号： C07D417/04
摘要： The invention is directed to 5,5-disubstituted-indolizinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译： 本发明涉及5,5-二取代的中氮茚酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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公开(公告)号：US20150175621A1
公开(公告)日：2015-06-25
申请号：US14382123
申请日：2013-03-01
申请人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
发明人： Kenneth W Bair , Timm R Baumeister , Peter Dragovich , Francis Gosselin , Po-Wai Yuen , Mark Zak , Xiaozhang Zheng
IPC分类号： C07D495/04 , A61K31/444 , C07D487/04 , A61K31/519 , A61K45/06 , A61K31/506 , A61K31/4545 , A61K31/5377 , A61K31/496 , C07D471/04 , C07D491/048
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
摘要翻译： 公开了某些吡啶基和嘧啶基亚砜和砜化合物，包含这些化合物的药物组合物和使用这些化合物的治疗方法。
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8.发明授权公开(公告)号：US08461328B2
公开(公告)日：2013-06-11
申请号：US13004808
申请日：2011-01-11
申请人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
发明人： Srinivasan Babu , Phillippe Bergeron , Peter Dragovich , Hazel Joan Dyke , Paul Gibbons , Stefan Gradl , Emily Hanan , Christopher Hurley , Tony Johnson , Michael Koehler , Janusz Kulagowski , Sharada Labadie , Joseph Lyssikatos , Rohan Mendonca , Rebecca Pulk , Stuart Ward , Bohdan Waszkowycz , Mark Zak
IPC分类号： A61P11/06 , A61P17/06 , A61P19/02 , A61P37/06 , C07D413/14 , C07D471/14
CPC分类号： C07D471/14 , C07D487/10
摘要： The invention provides novel compounds of formula I having the general formula: wherein R1, R2, R3, X and Y are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.
摘要翻译： 本发明提供具有以下通式的新颖的式I化合物：其中R1，R2，R3，X和Y如本文所述。 因此，化合物可以以药学上可接受的组合物提供，并用于治疗免疫学或过度增殖性疾病。
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公开(公告)号：US07582626B2
公开(公告)日：2009-09-01
申请号：US11955144
申请日：2007-12-12
申请人： Chinh V. Tran , Frank Ruebsam , Yuefen Zhou , Peter Dragovich , Alan X. Xiang
发明人： Chinh V. Tran , Frank Ruebsam , Yuefen Zhou , Peter Dragovich , Alan X. Xiang
IPC分类号： C07D417/04 , A61K31/549
CPC分类号： C07D417/04 , C07D417/14
摘要： The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating hepatitis C virus infections: wherein Z is X is N or CR9; Y is —(CR4R5)n—; n is 2, 3, 4, or 5; and R1 through R9 are defined herein.
摘要翻译： 本发明涉及式I的5,6-二氢-1H-吡啶-2-酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物：其中Z是X是N或CR 9; Y是 - （CR4R5）n-; n为2,3,4或5; 并且R1至R9在本文中定义。
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公开(公告)号：US20080275032A1
公开(公告)日：2008-11-06
申请号：US11898334
申请日：2007-09-11
申请人： Yuefen Zhou , Liansheng Li , Stephen E. Webber , Peter Dragovich , Douglas E. Murphy , Chinh V. Tran , Jingjing Zhao , Frank Ruebsam
发明人： Yuefen Zhou , Liansheng Li , Stephen E. Webber , Peter Dragovich , Douglas E. Murphy , Chinh V. Tran , Jingjing Zhao , Frank Ruebsam
IPC分类号： A61K31/549 , C07D401/04 , C07D285/26 , A61K31/497 , A61P31/14
CPC分类号： C07D417/04 , C07D417/14
摘要： The invention is directed to pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
摘要翻译： 本发明涉及哒嗪酮化合物和含有可用于治疗丙型肝炎病毒感染的化合物的药物组合物。
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