公开(公告)号：US20050009846A1

公开(公告)日：2005-01-13

申请号：US10742237

申请日：2003-12-18

申请人： Peter Fischer ,  Mike Jarman ,  Ted McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

发明人： Peter Fischer ,  Mike Jarman ,  Ted McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

IPC分类号： A61K31/52 ,  A61P17/06 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07D473/16 ,  C07D473/14

CPC分类号： C07D473/16

摘要： The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof wherein R2 is 2-hydroxymethylpyrrolidin-1-yl, or NHCH(R4)CH(R3)OH, wherein R3 is hydrogen or methyl and R4 is methyl, ethyl or isopropyl; R6 is 3-nitrophenylamino, 3,4-dimethoxybenzylamino, 3-iodobenzyl-amino, pyrid-2-yl-methylamino, pyrid-4-yl-methylamino or indan-5-amino; R9 is isopropyl or cyclopentanyl. In a further aspect, the invention relates to pharmaceutical compositions comprising said compounds, and the use thereof in treating antiproliferative disorders and or viral disorders.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中R2是2-羟甲基吡咯烷-1-基或NHCH（R4）CH（R3）OH，其中R3是氢或甲基，R4是甲基，乙基或 异丙基 R6是3-硝基苯基氨基，3,4-二甲氧基苄基氨基，3-碘苄基 - 氨基，吡啶-2-基 - 甲基氨基，吡啶-4-基 - 甲基氨基或茚满-5-氨基; R9是异丙基或环戊基。 在另一方面，本发明涉及包含所述化合物的药物组合物及其在治疗抗增生性疾病和/或病毒性疾病中的用途。

公开(公告)号：US20050256142A1

公开(公告)日：2005-11-17

申请号：US11033692

申请日：2005-01-11

申请人： Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

发明人： Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

IPC分类号： A61K31/52 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P17/14 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  C07D473/16 ,  C07D473/12

CPC分类号： C07D473/16 ,  A61K31/52 ,  Y02A50/411

摘要： The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

摘要翻译： 本发明涉及式1化合物或其药学上可接受的盐，其中R 1和R 2之一是甲基，乙基或异丙基，另一个是H; R 3和R 4各自独立地为H，支链或非支链C 1 -C 6烷基或芳基 并且其中R 3和R 4中的至少一个不是H; R 5是支链或非支链C 1 -C 5烷基或C 1 -C 3亚烷基 其中每一个可以任选地被一个或多个OH基团取代; R 6，R 7，R 8和R 9各自独立地为H，卤素，NO 3， 2，OH，OMe，CN，NH 2，COOH，CONH 2或SO 2 NH 2， / SUB>。 本发明的另一方面涉及包含式1化合物的药物组合物，以及所述化合物在治疗增殖性疾病，病毒性疾病，中枢神经系统疾病，糖尿病，中风，脱发或神经变性疾病中的用途。

公开(公告)号：US20060183760A1

公开(公告)日：2006-08-17

申请号：US11238533

申请日：2005-09-28

申请人： Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

发明人： Peter Fischer ,  Michael Jarman ,  Edward McDonald ,  Bernard Nutley ,  Florence Raynaud ,  Stuart Wilson ,  Paul Workman

IPC分类号： A61K31/52 ,  C07D473/12

CPC分类号： C07D473/16

摘要： The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or un branched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，其中R 1和R 2中的一个为甲基，乙基或异丙基，另一个为H; R 3和R 4各自独立地为H，支链或非支链C 1 -C 6烷基，或 芳基，并且其中R 3和R 4中的至少一个不是H; R 5是支链或非支链C 1 -C 5烷基或C 1 -C 3亚烷基 其中每一个可以任选地被一个或多个OH基团取代; R 6，R 7，R 8和R 9各自独立地为H，卤素，NO 3， 2，OH，OMe，CN，NH 2，COOH，CONH 2或SO 2 NH 2， / SUB>。 本发明的另一方面涉及包含式1化合物的药物组合物，以及所述化合物在治疗增殖性疾病，病毒性疾病，中枢神经系统疾病，糖尿病，中风，脱发或神经变性疾病中的用途。

公开(公告)号：US10005225B2

公开(公告)日：2018-06-26

申请号：US14425657

申请日：2012-09-06

申请人： Peter Fischer ,  Gerald Kreindl ,  Jakob Harming ,  Christine Thanner ,  Christian Schön

发明人： Peter Fischer ,  Gerald Kreindl ,  Jakob Harming ,  Christine Thanner ,  Christian Schön

IPC分类号： B29C59/02 ,  B29C59/00 ,  G03F7/00 ,  B82Y10/00 ,  B82Y40/00

CPC分类号： B29C59/022 ,  B29C59/002 ,  B29C2059/023 ,  B29K2821/003 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03F7/0017

摘要： A structure stamp with a flexible stamp which has a microstructured or nanostructured stamp surface for embossing of an embossing structure which corresponds to the stamp surface on an embossing surface, and a frame for clamping the stamp. Moreover, the invention relates to a device for embossing an embossing pattern on an embossing surface with the following features: a stamp receiver for accommodating and moving a structure stamp, an embossing material receiver for accommodating and placing an embossing material opposite the structure stamp, an embossing element drive for moving an embossing element along the structure stamp.

公开(公告)号：US09513881B2

公开(公告)日：2016-12-06

申请号：US12142952

申请日：2008-06-20

申请人： Peter Fischer ,  Hendrik Haddorp ,  Oliver Koeth ,  Andreas Nauerz

发明人： Peter Fischer ,  Hendrik Haddorp ,  Oliver Koeth ,  Andreas Nauerz

IPC分类号： G06F9/44 ,  G06F9/445

CPC分类号： G06F8/36 ,  G06F8/60

摘要： A system for assisted generation of composite applications which are composed of instantiable components includes a portal system executing in memory of a computer to:a) dynamically access a data source of one or more components being potentially suitable for being used within the composite application,b) parse the data source for a predetermined searched component according to a predetermined functionality specification standard,c) rank found components according to predetermined ranking criteria,d) define a list of selected usable components from the ranking,e) store at least a subset of the selected components locally, and,f) automatically deploy the composite application from the selected components.

摘要翻译： f）从所选组件自动部署组合应用程序。

公开(公告)号：US08332459B2

公开(公告)日：2012-12-11

申请号：US12388648

申请日：2009-02-19

申请人： Michael Blum ,  Peter Fischer ,  Hendrik Haddorp ,  Stefan Hepper ,  Stefan Liesche ,  Michael Marks ,  Thomas Stober

发明人： Michael Blum ,  Peter Fischer ,  Hendrik Haddorp ,  Stefan Hepper ,  Stefan Liesche ,  Michael Marks ,  Thomas Stober

IPC分类号： G06F15/16

CPC分类号： G06F9/5038 ,  G06F9/44521 ,  G06F9/505 ,  Y02D10/22

摘要： A predetermined business task of a composite application can be fulfilled. The composite application can include a set of components. The composite application is instantiated by a template means and a predefined collaborative context module controls the interaction of the set of components during the runtime of the composite application. A set of components fulfilling individual services on individual different server systems is leveraged by the composite application. During the instantiation of the composite application from a template, the referenced components (as types) are instantiated leading to runtime instances of these components. The interaction of the different components is controlled on individual different server systems utilizing a primary context module. The primary context module communicates with an appropriate collaborative module implemented locally on the respective set of servers, where the local context modules act as secondary context modules in relation to the primary context modules. For each of the secondary context modules, local components communicate to control the interaction of components.

摘要翻译： 组合应用程序的预定业务任务可以满足。 复合应用程序可以包括一组组件。 复合应用程序由模板手段实例化，预定义的协作上下文模块控制组合应用程序运行时期间组件集的交互。 复合应用程序利用一组满足个别不同服务器系统上个性化服务的组件。 在从模板实例化复合应用程序期间，引用的组件（作为类型）被实例化，导致这些组件的运行时实例。 利用主上下文模块，在不同的服务器系统上控制不同组件的交互。 主上下文模块与在相应的服务器集合上本地实现的适当的协作模块进行通信，其中本地上下文模块作为相对于主上下文模块的辅助上下文模块。 对于每个辅助上下文模块，本地组件进行通信以控制组件的交互。

公开(公告)号：US20120236311A1

公开(公告)日：2012-09-20

申请号：US13512602

申请日：2010-12-06

申请人： Hans Bettermann ,  Peter Fischer ,  Arno Goedecke Reichelt ,  Irmgard Buder ,  Volker Peinecke

发明人： Hans Bettermann ,  Peter Fischer ,  Arno Goedecke Reichelt ,  Irmgard Buder ,  Volker Peinecke

IPC分类号： G01N21/59

CPC分类号： H01M8/04447 ,  G01N21/67 ,  H01M8/04089 ,  H01M8/04455 ,  Y02E60/50

摘要： The invention relates to a method for monitoring and/or regulating fuel cells, in particular comprising determining the composition of the operating gases of the fuel cells. The method comprises the following steps: introducing the gas mixture to be analyzed into a measuring cell (1); producing an arc in the measuring cell (1); absorbing the radiation emitted by the arc; optical filtering of the emitted radiation and/or spectral decomposition of the emitted radiation; converting the emitted radiation into an electric signal; evaluating the electric signal.

摘要翻译： 本发明涉及用于监测和/或调节燃料电池的方法，特别地包括确定燃料电池的工作气体的组成。 该方法包括以下步骤：将要分析的气体混合物引入测量池（1）中; 在测量单元（1）中产生电弧; 吸收由电弧发射的辐射; 所发射的辐射的光学滤波和/或发射的辐射的光谱分解; 将发射的辐射转换成电信号; 评估电信号。

公开(公告)号：US08235639B2

公开(公告)日：2012-08-07

申请号：US12196685

申请日：2008-08-22

申请人： Theo Hug ,  Peter Fischer ,  Heinz Bötchi

发明人： Theo Hug ,  Peter Fischer ,  Heinz Bötchi

IPC分类号： B42C11/00 ,  B42C13/00 ,  B42C11/02 ,  B42C11/04 ,  B42B9/00

CPC分类号： B42C19/08 ,  B42C9/0006 ,  B42C11/02 ,  B65H2301/321 ,  B65H2301/363 ,  B65H2405/50 ,  B65H2701/182 ,  B65H2701/18282

摘要： A method for producing adhesive-bound book blocks from gathered signatures for which the individual signatures forming a non-bound book block are supplied while positioned on the spine on a transfer section to an opened conveying clamp on a perfect binder and are subsequently held while clamped in by the closed conveying clamp along the flat outer surfaces. The gathered signatures of a book block are released in an additional conveying section from the conveying clamp in order to be aligned while guided. Prior to leaving the conveying section for aligning the signatures, the signatures are clamped in once more by the conveying clamps along the flat outer surfaces, so that they can be conveyed to further processing locations.

摘要翻译： 一种用于从收集的签名生成粘合剂书本块的方法，其中形成无约束书本块的各个签名在位于转印部分上的书脊上的同时被提供给在完美的粘合剂上的打开的输送夹具上，并且随后被夹持 通过沿着平坦的外表面的封闭输送夹具。 书本块的收集的签名从输送夹具释放在另外的输送部分中，以便在被引导的同时被对准。 在离开用于对准签名的输送部分之前，通过输送夹具沿着平坦的外表面再次夹紧签名，使得它们可以被输送到另外的处理位置。

公开(公告)号：US20090250616A1

公开(公告)日：2009-10-08

申请号：US12304135

申请日：2007-05-29

申请人： Torsten J. Solf ,  Peter Fischer

发明人： Torsten J. Solf ,  Peter Fischer

IPC分类号： G01T1/166 ,  G01R35/00 ,  H03H11/26 ,  G01J5/10

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G04F10/005

摘要： In a radiation detector (10) for a time of flight positron emission tomography (PET) scanner (2), a radiation sensitive member (20) generates a signal (22) indicative of a radiation detection event. A time to digital converter (34) includes digital delay elements (40) operatively interconnected as a ring oscillator (36, 36′) and readout circuitry (50, 52, 60, 82, 84, 86, 88) configured to generate a timestamp for the radiation detection event based at least on a state of the ring oscillator when the signal is generated. Delay trim elements (46) operatively connected to the digital delay elements set a substantially common delay for the digital delay elements. Additionally or alternatively, the digital delay elements (40) include readout buffers (48′) having transition times substantially longer than a delay of the digital delay elements, analog to digital converters (82, 84) digitize values of the delay elements, and decoding circuitry (86, 88) computes the state of the ring oscillator (36′) based on the digitized values.

摘要翻译： 在用于飞行时间正电子发射断层摄影（PET）扫描仪（2）的放射线检测器（10）中，辐射敏感部件（20）产生指示辐射检测事件的信号（22）。 时间到数字转换器（34）包括作为环形振荡器（36,36'）可操作地互连的数字延迟元件（40）和被配置为生成时间戳的读出电路（50,52,60,82,84,86,88） 用于当产生信号时至少基于环形振荡器的状态的辐射检测事件。 可操作地连接到数字延迟元件的延迟微调元件（46）为数字延迟元件设置基本上公用的延迟。 附加地或替代地，数字延迟元件（40）包括读出缓冲器（48'），其具有比数字延迟元件的延迟更多的转换时间，模数转换器（82,84）数字化延迟元件的值，并且解码 电路（86,88）基于数字化值来计算环形振荡器（36'）的状态。

公开(公告)号：US20080003080A1

公开(公告)日：2008-01-03

申请号：US11823718

申请日：2007-06-28

申请人： Christian Abegglen ,  Peter Fischer

发明人： Christian Abegglen ,  Peter Fischer

IPC分类号： B42C9/00

CPC分类号： B42C9/0031 ,  Y10S412/90 ,  Y10S412/901

摘要： A glue applicator for applying an adhesive to the spine of a book block or to adjacent areas of a book block of stacked printed sheets being conducted past the glue applicator includes a tank holding liquid adhesive, into which at least one glue applicator roll dips to take up the adhesive and to transfer it to the spine of the book block, the roll being driven in the same travel direction as the book block, wherein the glue applicator roll works together with a doctor blade which is installed above the surface of the glue in the tank, and wherein the doctor blade determines the thickness of the adhesive film to be transferred to the spine of the book block through variation of its distance from the glue applicator roll, and where an actuating element for the doctor blade is positively connected to a cam disk, which is driven by a motor.

摘要翻译： 用于将粘合剂施加到书芯的脊柱或通过涂胶器穿过的堆叠的打印片材的书本块的相邻区域的胶粘剂施加器包括容纳液体粘合剂的容器，至少一个胶水涂布器辊浸入其中 粘合剂并将其转移到书芯的脊柱上，该卷筒以与书芯相同的行进方向驱动，其中胶涂机辊与安装在胶水表面上方的刮刀一起工作 罐，并且其中刮刀通过改变其距离胶粘剂辊的距离来确定待传送到书芯的脊柱的粘合剂膜的厚度，并且其中用于刮刀的致动元件被正确连接到 凸轮盘由电机驱动。