公开(公告)号：US09198639B2

公开(公告)日：2015-12-01

申请号：US12084933

申请日：2006-11-09

申请人： Peter Frinking ,  Marcel Arditi ,  Nicolas Rognin ,  Feng Yan

发明人： Peter Frinking ,  Marcel Arditi ,  Nicolas Rognin ,  Feng Yan

IPC分类号： G06K9/00 ,  A61B6/00 ,  A61B5/05 ,  A61B8/08 ,  G01S7/52

CPC分类号： A61B8/481 ,  A61B8/08 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52041 ,  G01S7/52071 ,  G01S7/52074

摘要： A system for facilitating the detection of an immobilized contrast agent in medical imaging applications is proposed. The system includes means for providing a sequence of a total number of input images obtained at corresponding acquisition instants by imaging a body-part of a patient subjected to an administration of a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding portion of the body-part possibly including said contrast agent, and means for reducing a contribution of the circulating contrast agent within the body-part in at least one selected input image; the means for reducing includes means for creating a filtered image corresponding to each selected input image by replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in a set of multiple input images including the selected input image, the set of multiple input images consisting of a number of input images lower than the total number.

摘要翻译： 提出了一种便于在医学成像应用中检测固定的造影剂的系统。 该系统包括用于提供在对应的获取时刻获得的输入图像的总数的序列的装置，其通过对经受施用能够在患者内循环的造影剂并且基本上固定在患者身上的患者的体部成像 每个输入图像包括多个输入值，每个输入值指示对可能包括所述造影剂的身体部分的对应部分的询问信号的响应;以及用于减少循环造影剂在所述生物靶内的贡献的装置 至少一个所选输入图像中的身体部分; 用于减少的装置包括用于通过用一组相应的滤波值替换所选择的输入图像的一组输入值来创建与每个所选择的输入图像相对应的滤波图像的装置，每个滤波值代表相应部分的最低响应 包括所选择的输入图像的一组多个输入图像中的身体部分的多个输入图像组合，所述多个输入图像由少于总数的多个输入图像组成。

公开(公告)号：US20090253986A1

公开(公告)日：2009-10-08

申请号：US12084933

申请日：2006-11-09

申请人： Peter Frinking ,  Marcel Arditi ,  Nicolas Rognin ,  Feng Yan

发明人： Peter Frinking ,  Marcel Arditi ,  Nicolas Rognin ,  Feng Yan

IPC分类号： A61B6/00 ,  A61B8/00 ,  G06K9/00

CPC分类号： A61B8/481 ,  A61B8/08 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52041 ,  G01S7/52071 ,  G01S7/52074

摘要： A system for facilitating the detection of an immobilized contrast agent in medical imaging applications is proposed. The system includes means for providing a sequence of a total number of input images obtained at corresponding acquisition instants by imaging a body-part of a patient subjected to an administration of a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding portion of the body-part possibly including said contrast agent, and means for reducing a contribution of the circulating contrast agent within the body-part in at least one selected input image; the means for reducing includes means for creating a filtered image corresponding to each selected input image by replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in a set of multiple input images including the selected input image, the set of multiple input images consisting of a number of input images lower than the total number.

摘要翻译： 提出了一种便于在医学成像应用中检测固定的造影剂的系统。 该系统包括用于提供在对应的获取时刻获得的输入图像的总数的序列的装置，其通过对经受施用能够在患者内循环的造影剂并且基本上固定在患者身上的患者的体部成像 每个输入图像包括多个输入值，每个输入值指示对可能包括所述造影剂的身体部分的对应部分的询问信号的响应;以及用于减少循环造影剂在所述生物靶内的贡献的装置 至少一个所选输入图像中的身体部分; 用于减少的装置包括用于通过用一组相应的滤波值替换所选择的输入图像的一组输入值来创建与每个所选择的输入图像相对应的滤波图像的装置，每个滤波值代表相应部分的最低响应 包括所选择的输入图像的一组多个输入图像中的身体部分的多个输入图像组合，所述多个输入图像由少于总数的多个输入图像组成。

公开(公告)号：US08496591B2

公开(公告)日：2013-07-30

申请号：US11794182

申请日：2005-12-21

申请人： Marcel Arditi ,  Peter Frinking ,  Nicolas Rognin

发明人： Marcel Arditi ,  Peter Frinking ,  Nicolas Rognin

IPC分类号： A61B8/14 ,  G06K9/00

CPC分类号： A61B8/06 ,  A61B8/481

摘要： A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a perfusion of a contrast agent in a body-part under analysis, the contrast agent being administered as a bolus and undergoing a significant destruction during a passage of the contrast agent in the body-part, means for associating the echo-power signal to a model function including the product between a bolus function indicative of the passage of the contrast agent without said destruction and a reperfusion function indicative of a reperfusion of the contrast agent in the body part following the destruction corresponding to a substantially constant inflow of the contrast agent, and means for estimating at least one perfusion indicator from the bolus function and/or the reperfusion function.

摘要翻译： 提出了灌注评估系统。 该系统包括用于提供指示在分析的身体部位中的造影剂的灌注的回波功率信号的装置，所述造影剂作为推注施用并在造影剂在体内通过期间经历显着的破坏 - 将所述回波功率信号与模型功能相关联的模块功能，所述模型功能包括所述产品在指示所述造影剂通过之前没有所述破坏的推注功能和指示所述造影剂在体内部分再灌注的再灌注功能 对应于造影剂的基本上恒定的流入的破坏，以及用于从推注功能和/或再灌注功能估计至少一个灌注指示符的装置。

公开(公告)号：US20090304593A1

公开(公告)日：2009-12-10

申请号：US12520839

申请日：2007-12-21

申请人： Peter Frinking ,  Tristan Messager ,  Marcel Arditi ,  Nicolas Rognin

发明人： Peter Frinking ,  Tristan Messager ,  Marcel Arditi ,  Nicolas Rognin

IPC分类号： A61K49/00 ,  A61P43/00 ,  G06K9/00 ,  A61B8/00

CPC分类号： G01S7/52041 ,  A61B8/481 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52071 ,  G01S7/52074

摘要： An embodiment of a solution is proposed for imaging a body-part that is perfused with a contrast agent. A corresponding method includes the step of providing a sequence of input images (for example, acquired with an ultrasound scanner); the input images offer a digital representation over time of the body-part. Each input image includes a plurality of input values (i.e., pixel or voxel values); each input value is indicative of a response to an interrogation signal (such as an echo signal for ultrasound waves) of a corresponding location of the body-part, which possibly includes the contrast agent. The method further includes the step of generating at least one filtered image from a plurality of selected ones of the input images (such as all of them or a subset thereof). Each filtered image includes a filtered value for each of a plurality of selected ones of the locations (for example, in a region of interest, or ROI). The filtered value of each selected location is indicative of the contrast agent that leaves the selected location after being substantially stationary at the selected location for a period of time, which is comprised between a first non-zero threshold and a second threshold higher than the first threshold (such as because the contrast agent detaches from the location after having been immobilized thereon, or because it was moving very slowly). The filtered value is obtained by reducing, where present, a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than the first threshold, and by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or longer than the second threshold.

摘要翻译： 提出了一种解决方案的实施例，用于对用造影剂灌注的身体部位进行成像。 相应的方法包括提供输入图像序列（例如，用超声波扫描器获取）的步骤; 输入图像随着身体部位的时间而提供数字表示。 每个输入图像包括多个输入值（即像素或体素值）; 每个输入值表示对可能包括造影剂的身体部位的对应位置的询问信号（例如超声波的回波信号）的响应。 该方法还包括从输入图像中的多个所选择的图像生成至少一个滤波图像（例如它们全部或其子集）的步骤。 每个滤波图像包括针对多个选择的位置（例如，在感兴趣区域或ROI中）中的每一个的滤波值。 每个所选择的位置的经滤波的值指示造影剂，其在被选择的位置基本上静止一段时间之后离开所选择的位置，该时间段包括在高于第一个的第一非零阈值和第二阈值之间 阈值（例如因为造影剂在被固定在其上之后从该位置分离，或者由于其移动非常缓慢）。 通过在现有的情况下，通过在等于或小于第一阈值的时间段内减少在所选择的位置处基本上静止在所选择的位置处的造影剂的贡献，并且通过减少 所述造影剂在所选择的输入图像的选定位置基本上静止等于或长于所述第二阈值的时间段。

公开(公告)号：US20120237098A1

公开(公告)日：2012-09-20

申请号：US13393633

申请日：2010-09-01

申请人： Nicolas Rognin ,  Marcel Arditi ,  Laurent Mercier ,  Peter Frinking

发明人： Nicolas Rognin ,  Marcel Arditi ,  Laurent Mercier ,  Peter Frinking

IPC分类号： G06K9/00

CPC分类号： G06T7/0016 ,  G06T2207/10132 ,  G06T2207/30104

摘要： An embodiment for analyzing a body-part of a patient is proposed. A corresponding data-processing method includes the steps of providing a sequence of input images representing the body-part over an analysis period, each input image including a set of input values each one being indicative of a response to an interrogation signal of a corresponding location of the body-part at a corresponding acquisition instant included in the analysis period, associating an analysis function of time with each one of a set of selected locations, the analysis function modeling a trend of the input values of the selected location in the sequence of input images, and providing a reference function of time for the analysis functions; in an embodiment, the data-processing method further includes comparing the analysis function of each selected location with the reference function to determine a polarity trend representing a trend over the analysis period of a polarity of a divergence between the analysis function of the selected location and the reference function, and creating a parametric image including a parametric value for each selected location, the parametric value being indicative of the polarity trend of the selected location.

摘要翻译： 提出了一种用于分析患者身体部位的实施例。 相应的数据处理方法包括以下步骤：在分析周期内提供表示身体部分的输入图像序列，每个输入图像包括一组输入值，每个输入值指示对相应位置的询问信号的响应 在分析周期中包括的相应采集时刻的身体部分相关联，将时间分析功能与一组选定位置中的每一个相关联，分析功能模拟所选位置的输入值的趋势， 输入图像，并提供分析功能的时间参考功能; 在一个实施例中，数据处理方法还包括将每个所选择的位置的分析功能与参考功能进行比较，以确定代表所选位置的分析功能的极性的分析周期的趋势的极性趋势和 参考功能，以及创建包括每个选定位置的参数值的参数图像，参数值表示所选位置的极性趋势。

公开(公告)号：US20120082359A1

公开(公告)日：2012-04-05

申请号：US13377143

申请日：2010-06-08

申请人： Marcel Arditi ,  Laurent Mercier ,  Nicolas Rognin ,  Peter Frinking ,  Eric Allemann

发明人： Marcel Arditi ,  Laurent Mercier ,  Nicolas Rognin ,  Peter Frinking ,  Eric Allemann

IPC分类号： G06K9/00

CPC分类号： A61B8/5215 ,  A61B5/72 ,  A61B6/5211 ,  A61B8/06 ,  A61B8/481 ,  G06T5/009 ,  G06T5/40 ,  G06T2207/10132

摘要： An embodiment is proposed for analyzing a body-part. A corresponding embodiment of a data-processing method includes the steps of providing a parametric map including a plurality of parameter values each one characterizing a corresponding location of the body-part, and determining at least one statistical indicator of at least one distribution of a plurality of analysis parameter values corresponding to selected analysis locations, each statistical indicator being indicative of a condition of an analysis region of the body-part defined by the analysis locations. In an embodiment, the step of determining at least one statistical indicator includes, for each distribution of the analysis parameter values, determining a saturation value partitioning an ordered sequence of processing parameter values, corresponding to selected processing locations at least including the analysis locations, into a first subset and a second subset consisting of a number of the processing parameter values being determined according to a predefined auto-scaling percentage, generating an auto-scaled map including, for each processing location, an auto-scaled value being equal to the corresponding processing parameter value if included in the second subset, or the saturation value if the corresponding processing parameter value is included in the first subset, and determining the at least one statistical indicator from the auto-scaled values corresponding to the analysis locations.

摘要翻译： 提出了用于分析身体部位的实施例。 数据处理方法的相应实施例包括以下步骤：提供包括表征身体部位的对应位置的多个参数值的参数图，以及确定至少一个多个分布的分布的统计指标 对应于所选分析位置的分析参数值，每个统计指标指示由分析位置定义的身体部分的分析区域的状况。 在一个实施例中，确定至少一个统计指示符的步骤包括对于分析参数值的每个分布，确定将对应于至少包括分析位置的所选处理位置的处理参数值的有序序列划分为饱和值， 由根据预定义的自动缩放百分比确定的多个处理参数值组成的第一子集和第二子集，生成自动缩放图，包括对于每个处理位置，自动缩放值等于相应的 如果包括在第二子集中则处理参数值，或者如果相应的处理参数值包括在第一子集中则为饱和值，以及根据与分析位置对应的自动缩放值确定至少一个统计指标。

公开(公告)号：US20090028406A1

公开(公告)日：2009-01-29

申请号：US11918589

申请日：2006-04-13

申请人： Marcel Arditi ,  Nicolas Rognin ,  Peter Frinking

发明人： Marcel Arditi ,  Nicolas Rognin ,  Peter Frinking

IPC分类号： A61B8/00

CPC分类号： G06T7/20 ,  A61B8/06 ,  A61B8/13 ,  A61B8/463 ,  A61B8/481 ,  A61B8/5238 ,  G01S15/8977 ,  G06T2207/30004

摘要： An embodiment of a medical imaging system is proposed. The system includes means for providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part, and means for associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time; the system further includes means for generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and means for displaying the sequence of computed images.

摘要翻译： 提出了一种医学成像系统的实施例。 该系统包括用于提供一系列记录的输入图像的装置，每个记录的输入图像在与造影剂灌注的身体部位的对应时刻提供数字表示，每个输入图像包括多个可视化值，每个可视化值表示对应部分 身体部分，以及用于将至少一个可视化值的输入图像中的对应集合的每个序列与时间的模型函数相关联的装置; 该系统还包括用于在其他时刻产生计算图像序列的装置，每个计算图像包括多个另外的可视化值，每个另外的可视化值由在相应的另外时刻从相关联的模型函数计算的瞬时功能值确定， 以及用于显示计算图像序列的装置。

公开(公告)号：US08512249B2

公开(公告)日：2013-08-20

申请号：US12520839

申请日：2007-12-21

申请人： Peter Frinking ,  Tristan Messager ,  Marcel Arditi ,  Nicolas Rognin

发明人： Peter Frinking ,  Tristan Messager ,  Marcel Arditi ,  Nicolas Rognin

IPC分类号： A61B5/05 ,  A61B6/00 ,  G06K9/00

CPC分类号： G01S7/52041 ,  A61B8/481 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52071 ,  G01S7/52074

摘要： An input image includes a plurality of input values (i.e., pixel or voxel values), each input value indicative of a response to an interrogation signal of a corresponding location of a body-part, which possibly includes a contrast agent. At least one filtered image is generated from a plurality of selected input images and includes a filtered value for each of a plurality of selected ones of the locations. Each filtered value is indicative of the contrast agent leaving the selected location and is obtained by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than a first threshold and by reducing a contribution of the contrast agent that is substantially stationary for a period of time equal to or longer than a second higher threshold.

摘要翻译： 输入图像包括多个输入值（即，像素或体元值），每个输入值指示对身体部位的相应位置的询问信号的响应，其可能包括造影剂。 从多个选择的输入图像生成至少一个滤波图像，并且包括针对多个选定位置中的每一个的滤波值。 每个滤波值表示离开所选择的位置的造影剂，并且是通过在所选择的输入图像的等于或小于第一阈值的时间段内减少基本上静止在选定位置的造影剂的贡献而获得的 并且通过减少在等于或长于第二较高阈值的时间段内基本静止的造影剂的贡献。

公开(公告)号：US08036437B2

公开(公告)日：2011-10-11

申请号：US11918589

申请日：2006-04-13

申请人： Marcel Arditi ,  Nicolas Rognin ,  Peter Frinking

发明人： Marcel Arditi ,  Nicolas Rognin ,  Peter Frinking

IPC分类号： G06K9/00

CPC分类号： G06T7/20 ,  A61B8/06 ,  A61B8/13 ,  A61B8/463 ,  A61B8/481 ,  A61B8/5238 ,  G01S15/8977 ,  G06T2207/30004

摘要： An embodiment of a medical imaging system is proposed. The system includes means for providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part, and means for associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time; the system further includes means for generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and means for displaying the sequence of computed images.

摘要翻译： 提出了一种医学成像系统的实施例。 该系统包括用于提供一系列记录的输入图像的装置，每个记录的输入图像在与造影剂灌注的身体部位的对应时刻提供数字表示，每个输入图像包括多个可视化值，每个可视化值表示对应部分 身体部分，以及用于将至少一个可视化值的输入图像中的对应集合的每个序列与时间的模型函数相关联的装置; 该系统还包括用于在其他时刻产生计算图像序列的装置，每个计算图像包括多个另外的可视化值，每个另外的可视化值由在相应的另外时刻从相关联的模型函数计算的瞬时功能值确定， 以及用于显示计算图像序列的装置。

公开(公告)号：US20110213244A1

公开(公告)日：2011-09-01

申请号：US13127389

申请日：2009-11-23

申请人： Peter Frinking ,  Laurent Mercier ,  Nicolas Rognin ,  Marcel Arditi

发明人： Peter Frinking ,  Laurent Mercier ,  Nicolas Rognin ,  Marcel Arditi

IPC分类号： A61B8/00

CPC分类号： A61B5/055 ,  A61B6/504 ,  A61B6/507 ,  A61B8/06 ,  A61B8/481 ,  G01R33/563 ,  G01R33/56366

摘要： A solution for diagnostic applications is proposed. Particularly, a corresponding diagnostic system includes means (903-906) for providing (A1-A3) a plurality of input signals representative of a body-part being perfused with a contrast agent over time, each input signal being indicative of a response to an interrogating stimulus of a corresponding location of the body-part possibly including the contrast agent, means (909-930) for generating (A4.1-A4.3) a plurality of filtered signals from selected input signals of selected locations, each filtered signal at each instant over time being generated from a corresponding selected input signal according to a portion of the selected input signal including said instant, and means (933-939) for monitoring (A4.4-A4.6) each filtered signal to detect a peak in the response to the interrogation stimulus of the corresponding selected location, the peak being detected in response to the fulfillment of a stability condition by a corresponding portion of the filtered signal.

摘要翻译： 提出了诊断应用的解决方案。 特别地，相应的诊断系统包括用于提供（A1-A3）多个输入信号的装置（903-906），所述输入信号表示随时间灌注造影剂的身体部位，每个输入信号指示对 用于询问可能包括造影剂的身体部位的对应位置的询问刺激，用于从所选位置的选定输入信号产生（A4.1-A4.3）多个经滤波的信号的装置（909-930），每个滤波信号 随着时间的推移，根据包括所述时刻的所选择的输入信号的一部分，从相应的所选择的输入信号产生每个时刻，以及用于监视（A4.4-A4.6）每个滤波信号的装置（933-939），以检测 响应于对应选择位置的询问激励的峰值，响应于由滤波信号的相应部分实现稳定性条件而检测到峰值。