摘要:
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
摘要:
A system and method for automatically creating a digital test materials to qualify and test forms processing systems, including preparing a handprint snippet database containing labeled handprint image snippets representing a unique human hand, preparing a form description file and a data content file, selecting handprint snippets from the handprint snippet data base to formulate a form using the data content file, creating a form image using the selected snippets according to the form description file, and, if desired, printing the form image.
摘要:
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
摘要:
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.
摘要:
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.
摘要:
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.
摘要:
Methods, devices and systems for compressing images are provided. One method includes creating halftone mask structures and applying compression coding techniques to arrayed pixels sorted using the halftone mask structures in order to convert an image to a compressed bi-level, halftoned image.
摘要:
A system that classifies or identifies hand printed or machine printed alphanumeric characters using an iterated least squares polynomial discriminant method is disclosed. Super-sampling of labeled training characters is performed prior to feature extraction. Feature extraction subsamples individual character images. The feature vectors and associated labelings are used to create a weight matrix. During iteration, the weight matrix, to be subsequently used for identification, is modified by determining which characters are incorrectly classified, or classified with too small a confidence, and replicating those characters during training to strengthen the correct classification. The correct classification is also strengthened by using negative feedback to inhibit incorrect classification by using negative values in the target vectors. The speed of the learning process is enhanced by maintaining intermediate matrices and step wise increasing the amount of each feature vector and the size of the sample set used during training. The memory efficiency utilization is enhanced by maintaining and modifying intermediate matrices and compressing the sparse binary features vectors.
摘要:
Methods, devices and systems for compressing images are provided. One method includes creating halftone mask structures and applying compression coding techniques to arrayed pixels sorted using the halftone mask structures in order to convert an image to a compressed multi-level, halftoned image.
摘要:
Methods and apparatus for constructing a classification weights matrix for a pattern recognition system are provided which enable large system feature sets to be reduced and yield at least the same level of performance achieved using the large feature set. Methods and apparatus are also described for determining (evaluating) the classification efficiency of selected subsets of a given feature set. Further aspects of the invention are directed to: (a) methods and apparatus for constructing reduced element classification weights matrices utilizing a genetic search process to find the subset having a maximum classification efficiency; and (b) pattern recognition systems (including, in particular, character identification systems), which utilize classifiers constructed in accordance with the aforementioned aspects of the invention to actually perform pattern recognition.