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    Collagen membrane made from porcine skin
    3.
    发明授权
    Collagen membrane made from porcine skin 有权
    由猪皮制成的胶原膜

    公开(公告)号：US07022358B2

    公开(公告)日：2006-04-04

    申请号：US10281123

    申请日：2002-10-28

    申请人： Zdenek Eckmayer ,  Rainer Dorstewitz ,  Lothar Schlösser ,  Josef Anton Böhni ,  Peter Geistlich

    发明人： Zdenek Eckmayer ,  Rainer Dorstewitz ,  Lothar Schlösser ,  Josef Anton Böhni ,  Peter Geistlich

    IPC分类号： A23J1/10 ,  A23J3/04 ,  A23L1/312

    CPC分类号： C08J5/18 ,  A22C13/0016 ,  A23J3/06 ,  A23L13/00 ,  B65D65/463 ,  C08J2389/06

    摘要： Collagen membranes are formed from porcine rinds (i.e., pig skins) for us in a variety of applications and, most preferably, for wrapping food products, such as hams and the like. First, after removing skins from the porcine, the skins are promptly frozen. In later processing, the rinds are thawed and then enzymatically defatted. Then, a quick alkalinic hydrolyzation is performed on the rinds. Then, an acidic hydrolyzation is performed on the rinds. The rinds are then ground into a gel-like fluid mass. Finally, the fluid mass is extruded, sheeted and dried into a collagen membrane. The collagen membrane produced can be, in preferred embodiments, used for wrapping food products, such as hams.

    摘要翻译： 在各种应用中，胶原膜由猪皮（即猪皮）形成，并且最优选用于包装食品，例如火腿等。 首先，在从猪除去皮肤后，皮肤迅速冷冻。 在后续处理中，将外皮解冻然后酶促脱脂。 然后，在外皮上进行快速碱性水解。 然后在外皮上进行酸性水解。 然后将外皮研磨成凝胶状流体块。 最后，将流体质量挤出，片状并干燥成胶原膜。 在优选实施例中，所生产的胶原膜可用于包装食品，例如火腿。

    Resorbable extracellular matrix for reconstruction of cartilage tissue
    5.
    发明授权
    Resorbable extracellular matrix for reconstruction of cartilage tissue 失效
    用于重建软骨组织的可再吸收细胞外基质

    公开(公告)号：US06326029B1

    公开(公告)日：2001-12-04

    申请号：US08894517

    申请日：1997-11-10

    申请人： Peter Geistlich ,  Myron Spector ,  Zdenek Eckmayer

    发明人： Peter Geistlich ,  Myron Spector ,  Zdenek Eckmayer

    IPC分类号： A61K3532

    摘要： A resorbable extracellular matrix for reconstruction of cartilage tissue, the matrix being substantially free from non-native collagen, and including a purified collagen II material formed form natural cartilage and having fibers of native collagen II which are physiologically acceptable for implant into a mammalian body.

    摘要翻译： 用于重建软骨组织的可再吸收的细胞外基质，所述基质基本上不含非天然胶原蛋白，并且包括由天然软骨形成的具有生理学上可接受的植入到哺乳动物体内的天然胶原II的纤维的纯化的胶原II。

    Method of making a collagen membrane from porcine skin
    6.
    发明授权
    Method of making a collagen membrane from porcine skin 有权
    从猪皮制造胶原膜的方法

    公开(公告)号：US06482240B1

    公开(公告)日：2002-11-19

    申请号：US09455811

    申请日：1999-12-07

    申请人： Zdenek Eckmayer ,  Rainer Dorstewitz ,  Lothar Schlösser ,  Josef Anton Böhni ,  Peter Geistlich

    发明人： Zdenek Eckmayer ,  Rainer Dorstewitz ,  Lothar Schlösser ,  Josef Anton Böhni ,  Peter Geistlich

    IPC分类号： C14C106

    CPC分类号： C08J5/18 ,  A22C13/0016 ,  A23J3/06 ,  A23L13/00 ,  B65D65/463 ,  C08J2389/06

    摘要： Collagen membranes are formed from porcine rinds (i.e., pig skins) for us in a variety of applications and, most preferably, for wrapping food products, such as hams and the like. First, after removing skins from the porcine, the skins are promptly frozen. In later processing, the rinds are thawed and then enzymatically defatted. Then, a quick alkalinic hydrolyzation is performed on the rinds. Then, an acidic hydrolyzation is performed on the rinds. The rinds are then ground into a gel-like fluid mass. Finally, the fluid mass is extruded, sheeted and dried into a collagen membrane. The collagen membrane produced can be, in preferred embodiments, used for wrapping food products, such as hams.

    摘要翻译： 在各种应用中，胶原膜由猪皮（即猪皮）形成，并且最优选用于包装食品，例如火腿等。 首先，在从猪除去皮肤后，皮肤迅速冷冻。 在后续处理中，将外皮解冻然后酶促脱脂。 然后，在外皮上进行快速碱性水解。 然后在外皮上进行酸性水解。 然后将外皮研磨成凝胶状流体块。 最后，将流体质量挤出，片状并干燥成胶原膜。 在优选实施例中，所生产的胶原膜可用于包装食品，例如火腿。

    METHODS AND COMPOSITIONS FOR ORAL PHARMACEUTICAL THERAPY
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR ORAL PHARMACEUTICAL THERAPY 有权
    口服药物治疗的方法和组合

    公开(公告)号：US20130089606A1

    公开(公告)日：2013-04-11

    申请号：US13701372

    申请日：2011-06-01

    申请人： Rolf W. Pfirrmann ,  Peter Geistlich

    发明人： Rolf W. Pfirrmann ,  Peter Geistlich

    IPC分类号： A61K31/549

    CPC分类号： A61K31/549 ,  A61K9/2846 ,  A61K9/4825 ,  A61K9/485 ,  A61K9/4891 ,  A61K31/54 ,  A61K31/541 ,  A61K2300/00

    摘要： It now has been found that oral administration of pharmaceutical agents, including N-methylol transfer agents such as Taurolidine may be used to provide efficacious blood plasma concentration of the agents for treatment of diseases by providing release of the active agent into the duodenum or jejunum of a patient and/or at a pH of about 5.4 to about 6.5. Embodiments of the invention therefore provide oral dosage forms, compositions and methods for administration of pharmaceutical agents to the duodenum or jejunum of a patient, and/or which release at a pH of about 5.4 to about 6.5.

    摘要翻译： 现在已经发现，可以使用包括N-羟甲基转移剂如Taurolidine在内的药物的口服给药提供用于治疗疾病的药物的有效血浆浓度，其通过将活性剂释放到十二指肠或空肠的十二指肠或空肠 患者和/或约5.4至约6.5的pH。 因此，本发明的实施方案提供了用于向患者的十二指肠或空肠施用药物的口服剂型，组合物和方法，和/或在约5.4至约6.5的pH下释放。

    Method and membrane for tissue regeneration
    10.
    发明授权
    Method and membrane for tissue regeneration 有权
    组织再生的方法和膜

    公开(公告)号：US08992946B2

    公开(公告)日：2015-03-31

    申请号：US13144428

    申请日：2010-01-18

    申请人： Peter Geistlich ,  Lothar Schloesser

    发明人： Peter Geistlich ,  Lothar Schloesser

    IPC分类号： A61K9/00 ,  A61L31/04 ,  A61L31/14

    CPC分类号： A61L31/044 ,  A61L31/146 ,  A61L31/148

    摘要： Tissue regeneration or grafting is promoted utilizing a structure including a multi-layer sheet of collagen membrane material which includes a purified collagen barrier sheet material derived from natural collagen-containing tissue, the barrier sheet material including a barrier layer with an outer smooth barrier face and a fibrous face opposite the smooth barrier face. The structure further includes a matrix layer of collagen sponge material adjacent to the fibrous face. The matrix layer of collagen sponge material is resorbed by a body of a subject at a substantially faster rate than the barrier sheet material.

    摘要翻译： 使用包括多层胶原膜材料的结构促进组织再生或接枝，所述胶原膜材料包括衍生自天然胶原蛋白的组织的纯化胶原阻挡片材料，所述阻挡片材料包括具有外侧光滑屏障面的阻挡层， 与光滑屏障面相对的纤维表面。 该结构还包括邻近纤维表面的胶原海绵材料的基质层。 胶原海绵材料的基质层以比阻挡片材料更快的速率被受试者的身体吸收。