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122 条记录 (耗时 0.035 秒)

    Process for preparation of pyridine derivatives
    2.
    发明申请
    Process for preparation of pyridine derivatives 有权
    吡啶衍生物的制备方法

    公开(公告)号：US20050014792A1

    公开(公告)日：2005-01-20

    申请号：US10888912

    申请日：2004-07-09

    申请人： Wolfgang Goehring ,  Peter Harrington ,  Lewis Hodges ,  David Johnston ,  Goesta Rimmler

    发明人： Wolfgang Goehring ,  Peter Harrington ,  Lewis Hodges ,  David Johnston ,  Goesta Rimmler

    IPC分类号： C07D213/82 ,  C07D213/85 ,  A61K31/4545 ,  A61K31/4439 ,  C07

    CPC分类号： C07D213/82 ,  C07D213/85

    摘要： The present invention relates to a process for the manufacture of compounds of formula wherein the substituents are as described herein which comprises the steps of a) reacting a compound of formula with a compound of formula to form a compound of formula b) converting the OH/═O function of compounds of formula XIV/XIVa into a leaving group P with a reagent containing a leaving group, selected from POCl3, PBr3, MeI and (F3CSO2)2O to form a compound of formula wherein P is halogen or trifluoromethanesulfonate; c) substituting R2 for the leaving group P by reacting compound XV with HR2 to form a compound of formula and d) hydrolyzing the nitrile function in an acidic medium selected from H2SO4, HCl and acetic acid, to form a compound of formula I The compounds of formula I are valuable intermediates for the manufacture of therapeutically active compounds which have NK-1 antagonist activity.

    摘要翻译： 本发明涉及制备下式化合物的方法，其中取代基如本文所述，其包括以下步骤：a）使式的化合物与式的化合物反应以形成式b的化合物：b）将OH / =式XIV / XIVa化合物的O官能团与含有离去基团的试剂选自POCl 3，PBr 3，MeI和（F3CSO 2）2 O形成离子基团P，以形成下式的化合物其中P为卤素或三氟甲磺酸酯; c）通过使化合物XV与HR 2反应，将R 2取代离去基团P以形成式的化合物，和d）在选自H 2 SO 4，HCl和乙酸的酸性介质中水解腈官能团，形成 式I化合物式I化合物是制备具有NK-1拮抗剂活性的治疗活性化合物的有价值的中间体。

    Injection device
    5.
    发明授权
    Injection device 有权

    公开(公告)号：US09675758B2

    公开(公告)日：2017-06-13

    申请号：US11579563

    申请日：2005-05-27

    申请人： David Johnston ,  Rosemary Habeshaw ,  Nigel Harrison

    发明人： David Johnston ,  Rosemary Habeshaw ,  Nigel Harrison

    IPC分类号： A61M5/20 ,  A61M5/32

    CPC分类号： A61M5/2033 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/326 ,  A61M2005/206

    摘要： The present invention concerns an injection device with a housing adapted to receive a syringe having a discharge nozzle, the housing having an indicator opening. There is a trigger and a forward drive arranged to act upon the syringe on actuation of the trigger to advance the syringe from a retracted position to an extended position thereby discharging the contents of the syringe through the discharge nozzle. A support member is in contacting juxtaposition with the housing and a return drive is supported by the support member and arranged to act upon the syringe after the contents of the syringe has been discharged so that the syringe can be withdrawn from the extended position to the retracted position. Advantageously, the support member is arranged in the housing so that the second drive does not obscure an inspection of the contents of the syringe through the indicator opening. Hence, it can be clearly determined whether the contents of the syringe have been expelled from the syringe.

    Optimizing security bits in a media access control (MAC) header
    6.
    发明授权
    Optimizing security bits in a media access control (MAC) header 有权
    优化媒体访问控制（MAC）头中的安全位

    公开(公告)号：US09270457B2

    公开(公告)日：2016-02-23

    申请号：US12347872

    申请日：2008-12-31

    申请人： David Johnston ,  Muthu Venkatachalam

    发明人： David Johnston ,  Muthu Venkatachalam

    IPC分类号： H04K1/00 ,  H04L9/08 ,  H04W12/02 ,  H04L29/06

    CPC分类号： H04L9/0891 ,  H04L69/22 ,  H04L2209/80 ,  H04W12/02

    摘要： A method of retrieving security information in a media access control (MAC) header by a wireless station may include receiving a data unit, such as a protocol data unit (PDU), from a remote wireless station. The PDU may include the MAC header. The method may also include reading two encryption key sequence (EKS) bits in the MAC header that denote both whether the data unit is encrypted and a position in an encryption key sequence for the data unit.

    摘要翻译： 通过无线站检索媒体访问控制（MAC）报头中的安全信息的方法可以包括从远程无线站接收诸如协议数据单元（PDU）的数据单元。 PDU可以包括MAC报头。 该方法还可以包括读取MAC报头中的两个加密密钥序列（EKS）位，其表示数据单元是否被加密，以及数据单元的加密密钥序列中的位置。

    SECURE KEY DERIVATION AND CRYPTOGRAPHY LOGIC FOR INTEGRATED CIRCUITS
    7.
    发明申请
    SECURE KEY DERIVATION AND CRYPTOGRAPHY LOGIC FOR INTEGRATED CIRCUITS 有权
    集成电路的安全关键衍生和拼接逻辑

    公开(公告)号：US20140189365A1

    公开(公告)日：2014-07-03

    申请号：US13730829

    申请日：2012-12-29

    申请人： George W. Cox ,  David Johnston ,  Jiangtao Li ,  Anand Rajan

    发明人： George W. Cox ,  David Johnston ,  Jiangtao Li ,  Anand Rajan

    IPC分类号： G06F21/72

    CPC分类号： G06F21/72 ,  G06F21/52 ,  G06F21/73 ,  G09C1/00 ,  H04L9/0866 ,  H04L2209/12

    摘要： A processor of an aspect includes root key generation logic to generate a root key. The root key generation logic includes a source of static and entropic bits. The processor also includes key derivation logic coupled with the root key generation logic. The key derivation logic is to derive one or more keys from the root key. The processor also includes cryptographic primitive logic coupled with the root key generation logic. The cryptographic primitive logic is to perform cryptographic operations. The processor also includes a security boundary containing the root key generation logic, the key derivation logic, and the cryptographic primitive logic. Other processors, methods, and systems are also disclosed.

    摘要翻译： 一方面的处理器包括生成根密钥的根密钥生成逻辑。 根密钥生成逻辑包括静态和熵位的源。 处理器还包括与根密钥生成逻辑耦合的密钥导出逻辑。 密钥推导逻辑是从根密钥导出一个或多个密钥。 处理器还包括与根密钥生成逻辑耦合的加密原语逻辑。 加密原语逻辑是执行加密操作。 处理器还包括包含根密钥生成逻辑，密钥导出逻辑和密码原语逻辑的安全边界。 还公开了其他处理器，方法和系统。

    Interactive electronic bill payment system
    9.
    发明授权
    Interactive electronic bill payment system 有权
    交互式电子账单支付系统

    公开(公告)号：US08645168B2

    公开(公告)日：2014-02-04

    申请号：US11797316

    申请日：2007-05-02

    申请人： Mike Schmidt ,  Ilan Grosman ,  David Johnston

    发明人： Mike Schmidt ,  Ilan Grosman ,  David Johnston

    IPC分类号： G06Q40/00 ,  G06F17/00

    CPC分类号： G06Q30/04 ,  G06Q20/102 ,  G06Q40/02 ,  G06Q40/08

    摘要： A system for coordinating the submission and processing of a bill according to predictive payment data of a plan. The system comprises a provider interface and an integrated database for receiving a predictive payment plan submitted from the provider interface. The system also has a predictive payment request of the plan storable in the database, the request including a plurality of predictive payment parameters. An adjudication engine is coupled to the integrated database, and an insertion function is used for inserting the predictive payment parameters into an adjudication rule set of the adjudication engine. The adjudication rule set is used for eventual adjudication of the predictive payment data, wherein adjudication of the predictive payment data results in the generation of the bill. The system also has a workflow engine for coordinating the processing of the electronic bill and for updating the bill information in response to processing.

    摘要翻译： 根据计划的预测支付数据协调提交和处理账单的系统。 该系统包括提供者接口和用于接收从提供者接口提交的预测性支付计划的集成数据库。 系统还具有可存储在数据库中的计划的预测支付请求，该请求包括多个预测支付参数。 裁定引擎耦合到集成数据库，并且使用插入功能将预测支付参数插入到裁判引擎的裁决规则集合中。 判决规则集用于对预测支付数据的最终判定，其中预测支付数据的判断导致账单的生成。 该系统还具有工作流引擎，用于协调电子账单的处理以及响应处理更新账单信息。

    Methods and Apparatus for Determination of Halohydrocarbons
    10.
    发明申请
    Methods and Apparatus for Determination of Halohydrocarbons 有权
    用于测定卤代烃的方法和装置

    公开(公告)号：US20130029427A1

    公开(公告)日：2013-01-31

    申请号：US13640312

    申请日：2011-04-14

    申请人： Harmesh K. Saini ,  Michael J. West ,  Qin Wang ,  James Garvey ,  Paul Rand ,  Marc Angelo ,  David Johnston ,  Robert Ormond ,  Ye Han

    发明人： Harmesh K. Saini ,  Michael J. West ,  Qin Wang ,  James Garvey ,  Paul Rand ,  Marc Angelo ,  David Johnston ,  Robert Ormond ,  Ye Han

    IPC分类号： G01N21/75

    CPC分类号： G01N21/78 ,  G01N21/75 ,  G01N33/18 ,  G01N33/1826 ,  Y10T436/19 ,  Y10T436/193333

    摘要： A real-time, on-line method and analytical system for determining halohydrocarbons in water which operate by (1) extracting on-line samples; (2) purging volatile halohydrocarbons from the water (e.g., with air or nitrogen); (3) carrying the purge gas containing the analytes of interest over a porous surface where the analytes are adsorbed; (4) recovering the analytes from the porous surface with heat (thermal desorption) or solvent (solvent elution) to drive the analytes into an organic chemical mixture; (5) generating an optical change (e.g., color change) in dependence upon a reaction involving the analytes and a pyridine derivative; and (6) measuring optical characteristics associated with the reaction to quantify the volatile halogenated hydrocarbon concentration.

    摘要翻译： 一种用于测定水中卤代烃的实时在线方法和分析系统，其操作为（1）提取在线样品; （2）从水中（例如用空气或氮气）吹扫挥发性卤代烃; （3）在分析物被吸附的多孔表面上携带含有感兴趣分析物的吹扫气体; （4）用热（热解吸）或溶剂（溶剂洗脱）从多孔表面回收分析物，以将分析物驱动到有机化学混合物中; （5）根据涉及分析物的反应和吡啶衍生物产生光学变化（例如，颜色变化）; 和（6）测量与反应相关的光学特性以量化挥发性卤代烃浓度。